Posted by SLS on November 8, 2000, at 21:08:32
In reply to Q. re atypical antipsychotics and dopamine -- Cam?, posted by anita on November 8, 2000, at 19:36:52
Meee 2
Anita, of the "atypicals", Risperdal has the *lowest* ratio of 5-HT2/DA2 receptor blockade. Risperdal also increases prolactin levels more than the other atypicals. Of the atypicals, Risperdal is the most like Haldol, and has the greatest potential to cause EPS. Zyprexa, on the other hand, has a very high 5-HT2/DA2 ratio. Perhaps Zyprexa has a low-dose DA-enhancing window that is more favorable than Risperdal. Of course, there is plenty of literature indicating that Risperdal works well to augment antidepressants. I have no way of knowing, but I have been hoping that these drugs act like amisulpride in this regard. Yooo 2? :-)
> Hi,
>
> I'd like to know if very low doses of risperidone or Zyprexa increase dopamine globally, not just in the mesocortical pathway via 5HT2A antagonism. In other words, do low doses of these meds work like amisulpride, which increases dopamine globally at low doses? For various reasons, it's very important that I try to find an answer to this question, so any input would be greatly appreciated.
>
> I am taking a low dose of risperidone (1mg/day) and it feels a lot like low-dose amisulpride.
>
> anita
poster:SLS
thread:48466
URL: http://www.dr-bob.org/babble/20001102/msgs/48474.html