Posted by AndrewB on March 18, 2000, at 8:50:47
In reply to Curiously detached, posted by JanetR on March 18, 2000, at 0:49:30
Jan,
When I feel that detached I am often reminded of a phrase from the Beatle's song Penny Lane, 'She feels as if she is in a play and she is anyway." I think you will be interested in the recent study (see below) that indicates a detached personality is associated with low function of the D2 recpetor. I know I've said it before to you, but I think you may benefit from a medicine you have available to you in Brazil called amisulpride (Socian). It will improve your D2-D3 receptor function and quite possibly make you feel less detached and more sociable. It has done that for me. It also could help your dysthymia and chronic fatigue. There are many studies showing this med. to be effective for dysthymia. It has been speculated that at least some people with chronic fatigue syndrome would benefit from a med. like amisulpride. The drug is very safe and has few side effects in general. I can send you more info. if you email me at andrewb@seanet.com
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Am J Psychiatry 2000 Feb;157(2):290-2Prediction of detached personality in healthy subjects by low
dopamine transporter binding.Laakso A, Vilkman H, Kajander J, Bergman J, paranta M, Solin O, Hietala J
Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland. akilaa@utu.fi
OBJECTIVE: Low striatal dopamine D(2) receptor binding in healthy human subjects has been associated with detached personality in studies using positron emission tomography (PET) and the Karolinska Scales of Personality questionnaire. The authors investigated whether a similar correlation exists between striatal dopamine transporter binding and detached personality. METHOD: Eighteen healthy volunteers participated in a PET study with the specific dopamine transporter ligand [(18)F]CFT ([(18)F]WIN 35,428) and completed the Karolinska Scales of Personality questionnaire form. RESULTS: Age-corrected dopamine transporter binding in the putamen, but not in the caudate, correlated negatively with detachment personality scores, especially in the right hemisphere. CONCLUSIONS: This finding supports the hypothesis that low dopaminergic neurotransmission is associated with detached personality. Furthermore, since [(18)F]CFT binding is thought to reflect the density of dopaminergic nerve terminals in the brain, the authors suggest that the neurodevelopmental formation of the brain dopaminergic system may influence adult personality traits.
poster:AndrewB
thread:27425
URL: http://www.dr-bob.org/babble/20000312/msgs/27445.html