Shown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by conundrum on February 21, 2010, at 13:24:08
http://www.nature.com/npp/journal/v27/n6/full/1395967a.html#tbl4
I had thought it was only a 5 HT2C antagonist but it also blocks the 5-HT2A receptor. This causes and increase in norepinephrine and dopamine. Other SSRIs don't do this.
Posted by Brainbeard on February 21, 2010, at 13:24:08
In reply to Fluoxetine(prozac) is a 5-HT2A antagonist., posted by conundrum on February 10, 2010, at 12:24:34
> I had thought it was only a 5 HT2C antagonist but it also blocks the 5-HT2A receptor. This causes and increase in norepinephrine and dopamine. Other SSRIs don't do this.
It should be noted, however, that the very mechanism of serotonin reuptake inhibition acts as an indiscriminate 5HT agonist, which means that Prozac's SRI counteracts its 5HT2A and -C antagonism. I guess some will still hold up, but, for instance, the typical deep sleep-inducing properties of 5HT2A-antagonism are clearly swept away by Prozac's other actions.
Posted by Brainbeard on February 21, 2010, at 13:24:08
In reply to Fluoxetine(prozac) is a 5-HT2A antagonist., posted by conundrum on February 10, 2010, at 12:24:34
Great link, by the way. The R-isomer of fluoxetine seems superior. But what do you know?
'Eli Lilly and Company halted development of the R- isomer of fluoxetine (Prozac) after Stage III clinical trials revealed unexpected cardiac side effects (Psychiatric News, December 1, 2000). The company had hoped that R-fluoxetine would replace fluoxetine, which was facing imminent expiration of its patent protection.'
(http://pn.psychiatryonline.org/content/36/24/17.3.full)
Cardiac side-effects.. How bad??!! A little tachycardia? Sudden deaths from heart failure? I hope it was bad enough to justify leaving this wonderful isomer behind.
It seems a company called Sepracor has investigated the use of the isolated S-isomer for migraines. Don't know where that went.
Posted by conundrum on February 21, 2010, at 13:24:08
In reply to Re: Fluoxetine(prozac) is a 5-HT2A antagonist., posted by Brainbeard on February 10, 2010, at 16:18:18
Thats why I am taking such a low dose to try to avoid that. I found some increased motivation with 5 mgs every other day. I increased to 5 and felt totally blunted worse than before and even did not want to eat.
I hope that if I stay at the low dose longer I will not only feel motivated but also reverse the anhedonia. Anhedonia seems to be the last symptom to go from antidepressant treatment. My pdoc had prescribed nefazodone as well but I'm scared of the liver toxicity since I already have Gilbert's Syndrome.
Posted by Phillipa on February 21, 2010, at 13:24:08
In reply to Re: Fluoxetine(prozac) is a 5-HT2A antagonist. » Brainbeard, posted by conundrum on February 10, 2010, at 16:44:00
No wonder my anxiety came back more than full force when took prozac 20mg for three days. How do women use prozac for a few days each month well some do. I also was afraid of the liver stuff with nefadazone and didn't take it as liver enzymes had just returned to normal. Phillipa
Posted by conundrum on February 21, 2010, at 13:24:09
In reply to Re: Fluoxetine(prozac) is a 5-HT2A antagonist., posted by Brainbeard on February 10, 2010, at 16:18:18
I can tell that its strong with SSRI because I get kinda tired and feel out of it in the afternoon. I had the same feeling on lexapro. Maybe adding a TCA with NRI properties would help.
I didn't have this when I started prozac the first time. its like my brain is saying "No More SERT inhibition!!!"
Posted by Laney on February 21, 2010, at 13:24:09
In reply to Re: Fluoxetine(prozac) is a 5-HT2A antagonist. » Brainbeard, posted by conundrum on February 10, 2010, at 18:24:56
Conundrum,
What do you mean by no more sert inhibition? I just started prozac like a week ago at 20mg. I really want it to work for getting off of paxil and for depression. Do you think it ever will? What is your experience with it? I'm feel sleepy an hour after taking it. I'm not better depression wise yet but I definitely don't want to feel flat. I never got a flat feeling from paxil even after 12 or 13 years. I just tried to go off of it to see if I really needed it anymore and when I went back on, it didn't work anymore.
Thanks and best wishes!
Laney
Posted by conundrum on February 21, 2010, at 13:24:09
In reply to Re: Fluoxetine(prozac) is a 5-HT2A antagonist., posted by Laney on February 11, 2010, at 10:09:45
At 20 mg it definetly has a lot of SERT inhibition. I did the same thing you did but with prozac. I started it at 20 mgs and took it for 4 years then stopped it and went back on but it didn't work. So I came off it and then my cognitive abilities went to crap once it really cleared my system. Now it seems any serotonergic drug I try I am hypersensitive to and they do make me feel flat. However the first time I tried prozac I felt better and didn't feel like I was takinga drug. Now when I take a serotonergic drugs I get this weird pinching headache near the front of my head and feel dopey in the afternoon. Wish I had never taken anything. 6 years drug free didn't return me to my previous selft either.
That is my experience. Maybe prozac will work for you. Maybe the doses are too high for your body now. That seems to be the case with me atleast. I felt some motivation recently with 2.5 mg prozac, but then blunted at 5mgs. I can't say what your experience will be. Be sure to give it atleast 4 weeks to start to work. Its a slow acting drug.
Posted by Laney on February 21, 2010, at 13:24:09
In reply to Re: Fluoxetine(prozac) is a 5-HT2A antagonist. » Laney, posted by conundrum on February 11, 2010, at 13:08:38
Conundrum,
So what are you taking now? If the small amount of Prozac isn't doing it then why not try something completely different?
Thanks for your reply.
Btw, what does SERT mean??
Thanks again,
Laney
Posted by conundrum on February 21, 2010, at 13:24:09
In reply to Re: Fluoxetine(prozac) is a 5-HT2A antagonist., posted by Laney on February 11, 2010, at 13:28:24
I am trying 5mgs every other day again, because at this dose it did help with motivation. Unfortunately I waited about a week and increased to taking 5 mg everyday. Then I started to feel even less motivated than before. For prozac with me now, less is more. In fact I'm thinking of taking even smaller doses. I may try 1mg or .5. I found this interesting post about microdoses of prozac. The guy who wrote this made an error with one of his calculations and mentions it in a last post. But it is interesting that he still feels an effect at this dose.
http://www.imminst.org/forum/index.php?showtopic=26058
>>>>>>>>>>>>>
1mg normal ssri effects but milder than full dose (amotivational and a I downt realy care feeling)
0,5mg the same as 1mg but the sexual becomes milder
0,25 very optimistic feeling (euphoric if combinated with coffee/cofffeine)0,06 to 0,01 only effects are a optimistic state of mind
0,02 to 0,06 optimistic feeling and a litle unfocused minddoses below 0,1 are a litle sedative
doses from 0,25 and up are a litle more stimulating
>>>>>>>>>>>The thing I don't understand is how I was able to function perfectly well on 20mgs and now I can't tolerate 5mgs.
If this doesn't work I would like to try a tricyclic with NRI properties. I will probably have to take an SNRI first, but I'm scared of the withdrawals from those drugs and I think they would be too serotenergic. Its like my brain is saying stop! No more serotonin!!!
SERT means Serotonin Transporter. It is the protein that brings serotonin back into the nerve cell and the protein that is blocked by SSRIs to increase serotonin. At lower doses prozac doesn't block enough SERT to increase serotonin a lot, but it does hit some other spots in the brain that can give other effects. We will see how that pans out. Wish this crap worked faster though.
Posted by Phillipa on February 21, 2010, at 13:24:10
In reply to Re: Fluoxetine(prozac) is a 5-HT2A antagonist. » Laney, posted by conundrum on February 11, 2010, at 14:09:47
Seriously same has happened to me with both benzos and luvox less is better but doesn't do it? Is it just meds in general as have taken all the ssri's and snri's? Phillipa
Posted by Phillipa on February 21, 2010, at 13:24:10
In reply to Re: Fluoxetine(prozac) is a 5-HT2A antagonist. » Laney, posted by conundrum on February 11, 2010, at 14:09:47
Oh wow!!!! the last poster on the link had lymes me also and currently IGG five bands on Western Blot still positive and the test result says positive for lymes but no doc will interpret the test even called the health dept and they gave me the CDC 25 letter website and I couldn't find their criteria for lymes but all websites I've visited say this is positive. That would explain me now what to do any suggestions? Phillipa
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