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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by YOGI BRONX on November 26, 2008, at 22:07:51
The FDA was supposed to act on approving Ixel by the end of October but, instead, notified the public that it wouldn't make that deadline.
I got tired of waiting and ordered some from Great Britain.
I noticed an elevation of energy,(especially), and mood by the end of the first day, even on only 25 mg. However, last night, after taking the second 25 mg. capsule, I experienced horrible dysuria. I could only manage to urinate enough to ease the pain and, after an hour and a half, repeated the process, - - all night long.
I think that milnacipran is interacting with one of my other meds to cause this but I don't know which one(s). Can anyone suggest a possible interaction. Otherwise, I will have to DC all my other meds and then add them back one at a time, (assuming that the milnacipran, all by itself, doesn't cause the dysuria).
Please help if you have any ideas. This med is the last resort for a number of us with refractory depression. I am being the guinea pig. It would be dreadful if a lousy side-effect prevented me from using what appears, on first blush, to be an effective treatment.
(The dysuria ameliorated today with my discontinuance of the milnacipran.)
Thanks.
Posted by desolationrower on November 27, 2008, at 0:01:49
In reply to Ixel + Dysuria, posted by YOGI BRONX on November 26, 2008, at 22:07:51
Do you mean ischuria? I think its a common side effect from noradrenergic drugs. I never had it that bad, but the combination of dry mouth and hesitancy is no fun. I would probably just restart at a lower dose until your body adjusts and increase slowly. Have you asked your doc for an alpha blocker?
-d/r
Posted by YOGI BRONX on November 27, 2008, at 5:36:38
In reply to Re: Ixel + Dysuria, posted by desolationrower on November 27, 2008, at 0:01:49
Dear desolationthrower,
Ischuria is a more appropriate term. Thank you. The difficulty in urination results in bladder retention. The pain arises from the full bladder, not from the urination itself.
I don't have a psychiatrist presently since the medication that I was interested in, (Milnacipran, naturally), is not officially available in the US. Moreover, I terminated my most recent one a few months ago because I thought that we weren't communicating productively. So, I don't have any professional to prescribe an alpha blocker. But I will look into it. Thanks again.
Cordially,
YOGI
Posted by Sigismund on November 27, 2008, at 16:36:25
In reply to Re: Ixel + Dysuria » desolationrower, posted by YOGI BRONX on November 27, 2008, at 5:36:38
Ixel is potent stuff.
The NE effect was intolerable for me at 25mg, but there was also something about it I liked.
There's nothing to say that 25mg is an inadequate dose for you, and you can always take more later.
Posted by bleauberry on December 11, 2008, at 17:18:55
In reply to Ixel + Dysuria, posted by YOGI BRONX on November 26, 2008, at 22:07:51
The cure for dysuria is Flomax. It is a prostate med that works by blocking the NE receptors of the prostate and bladder muscles. It works like a charm. There are two doses available. 2mg and 4mg. I found that even just a custom made 1mg dose worked very well. The lower the dose, the better, and less risk of any side effects.
I learned about Flomax from someone else on the med forum that had the same problem on desipramine. They told me Flomax worked perfectly and to try it. So I did, and it did.
You can also make custom doses of the Ixel, and 12.5mg twice a day instead of 25mg once a day.
This is the end of the thread.
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