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Dr. Bob is Robert Hsiung, MD,
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Posted by beckett2 on August 24, 2017, at 14:48:56
In reply to Re: Is vitamin B3 an effective alternative to NAD+? » beckett2, posted by sigismund on August 19, 2017, at 14:54:30
Sigi, sorry you've felt knocked about :( May I ask, why are you calling this NMN http://tinyurl.com/potentiator ? Maybe this isn't the product.
There is one on amazon with 300 mgs, but not with the other ingredients. I'll likely go with Life Extension.
I'd need to read about this, but what do you, or anyone here, think about a half dose for a teen?
Posted by sigismund on August 24, 2017, at 22:23:29
In reply to Re: Is vitamin B3 an effective alternative to NAD+? » sigismund, posted by beckett2 on August 24, 2017, at 14:48:56
The tinyurl link would not open, so I don't know what is there.
NMN is nicotinamide mononucleatide. Another further down the line precurser is nicotinamide riboside (in Elysium, no?) I don't know how NMN compares with NR. I like NMN myself.
It is said that people over 60 are often quite low in NAD+, so they might benefit most. But most of those people in the links for the San Diego clinic were young, and the relief they were given was extraordinary. But that was the NAD+ drip, which is is surely a stronger effect.
Did you see this? http://revgenetics.com
Posted by Lamdage22 on August 26, 2017, at 11:29:42
In reply to Re: Is vitamin B3 an effective alternative to NAD+? » beckett2, posted by sigismund on August 24, 2017, at 22:23:29
This is probably a no-go for people with schizophrenia right?
Posted by beckett2 on August 26, 2017, at 19:50:35
In reply to Re: Is vitamin B3 an effective alternative to NAD+?, posted by Lamdage22 on August 26, 2017, at 11:29:42
I'm not sure why it would be contraindicated. I would think it could be very helpful.
Posted by beckett2 on August 26, 2017, at 20:01:32
In reply to Re: Is vitamin B3 an effective alternative to NAD+? » beckett2, posted by sigismund on August 24, 2017, at 22:23:29
"Only the super-rich will reap the true rewards of the new technologies, commandeering evolution with intelligent design, editing their genomes and eventually merging with machines. Mr Harari envisages an elite caste of Homo sapiens evolving into something unrecognisable: Homo deus. In this brave new world, the rest of mankind will be left feeling like a Neanderthal hunter in Wall Street.
Have you seen this book? http://tinyurl.com/yctf97cr
Here's a brief review. Let's see if these links open.
http://tinyurl.com/y9rxolr3
Posted by sigismund on August 26, 2017, at 21:14:39
In reply to Re: Is vitamin B3 an effective alternative to NAD+? » sigismund, posted by beckett2 on August 26, 2017, at 20:01:32
>Homo deus
Oh yes. The utopians .......... what can you say? may be overtaken by events? and 4 and a half stars from so many people? Just as well we have the luxury of having so few problems and such an informed and cohesive public. Liberal democracy? That was Roosevelt and Eisenhower? It's very sad.
On the schizophrenia front......I see one of the videos in the San Diego clinic was about the use of NAD+ for depersonalisation (or something similar). That makes sense.
My experience of NMN is that it is not a stimulant....it feels just as calming as stimulating. I just feel better. No doubt you can take too much and make things worse. Some of the drugs for these conditions may lower NAD+ levels, in which case NMN may make sense.
Posted by SLS on August 27, 2017, at 15:35:27
In reply to Re: Is vitamin B3 an effective alternative to NAD+?, posted by sigismund on August 26, 2017, at 21:14:39
I'm not really interested in NAD+ and NMN as modulators of mood and anxiety. I'm mostly interested in the ability of NAD+ to arrest the shortening of telomeres and reverse the process to lengthen them again. There are some researchers who suggest that doing this will extend the viability of cells upon division and prevent aging. Lithium can do this, too.
My question is whether or not the megadosing of B3 niacin would increase NAD+.
- Scott
Posted by sigismund on August 27, 2017, at 23:43:15
In reply to Re: Is vitamin B3 an effective alternative to NAD+?, posted by SLS on August 27, 2017, at 15:35:27
>My question is whether or not the megadosing of B3 niacin would increase NAD+.
idk but from what I have read nicotinic acid would (but how much?) and niacinamide would not.
Posted by SLS on August 28, 2017, at 5:44:31
In reply to Re: Is vitamin B3 an effective alternative to NAD+? » SLS, posted by sigismund on August 27, 2017, at 23:43:15
> >My question is whether or not the megadosing of B3 niacin would increase NAD+.
>
> idk but from what I have read nicotinic acid would (but how much?) and niacinamide would not.Thanks. That helps a lot.
I hope all is well with you. I am not in a good place, but not in a bad place either. I am hoping to feel better when I figure out what the best dosage of prazosin is.
- Scott
Posted by Lamdage22 on August 29, 2017, at 12:04:20
In reply to Re: Is vitamin B3 an effective alternative to NAD+? » Lamdage22, posted by beckett2 on August 26, 2017, at 19:50:35
> I'm not sure why it would be contraindicated. I would think it could be very helpful.
Isnt it supposed to be dopaminergic?
Posted by Lamdage22 on August 29, 2017, at 12:08:11
In reply to Re: Is vitamin B3 an effective alternative to NAD+?, posted by Lamdage22 on August 29, 2017, at 12:04:20
Basically i dont want to go away from nature. 20g of Inositol for example is not natural, so i wont do it.
As far as supplements go i only take essential stuff in the quantity that is needed to get a healthy blood level. Nothing more and nothing less.
Posted by Lamdage22 on August 29, 2017, at 12:08:53
In reply to Re: Is vitamin B3 an effective alternative to NAD+?, posted by Lamdage22 on August 29, 2017, at 12:08:11
Im still on these meds but i am looking to change that. Slowly.
Posted by beckett2 on August 29, 2017, at 16:08:22
In reply to Re: Is vitamin B3 an effective alternative to NAD+?, posted by Lamdage22 on August 29, 2017, at 12:04:20
> > I'm not sure why it would be contraindicated. I would think it could be very helpful.
>
> Isnt it supposed to be dopaminergic?I don't know the answer to that one. My interest was in telomeric repair.
Posted by beckett2 on August 29, 2017, at 16:10:28
In reply to Re: Is vitamin B3 an effective alternative to NAD+?, posted by sigismund on August 26, 2017, at 21:14:39
> >Homo deus
>
> Oh yes. The utopians .......... what can you say? may be overtaken by events? and 4 and a half stars from so many people? Just as well we have the luxury of having so few problems and such an informed and cohesive public. Liberal democracy? That was Roosevelt and Eisenhower? It's very sad.
>Heartbroken here.
Posted by sigismund on August 30, 2017, at 2:10:38
In reply to Re: Is vitamin B3 an effective alternative to NAD+? » sigismund, posted by beckett2 on August 29, 2017, at 16:10:28
There was a politician here who said 'If you walk around with a smile on your face you haven't been paying attention', which is similar to something Heather Heyett's (sp?) mother or father said.
I know exactly what you mean. I am frightened (for my descendants).......but there you go....anyway I won't be around for that much longer really. But things can turn on a dime, either way.
Posted by sigismund on August 30, 2017, at 2:11:47
In reply to Re: Is vitamin B3 an effective alternative to NAD+?, posted by Lamdage22 on August 29, 2017, at 12:04:20
FWIW it does not feel dopaminergic to me.
Posted by Lamdage22 on August 30, 2017, at 13:26:42
In reply to Re: Is vitamin B3 an effective alternative to NAD+? » Lamdage22, posted by sigismund on August 30, 2017, at 2:11:47
how does it feel?
Posted by sigismund on September 1, 2017, at 2:44:54
In reply to Re: Is vitamin B3 an effective alternative to NAD+?, posted by Lamdage22 on August 30, 2017, at 13:26:42
>how does it feel?
Well.......to begin with it was really noticeable. I would describe it as a kind of euphoria.....but that is for me and I am in poor health in my mid 60s, dragging myself around......so I wondered if my levels of NAD+ were low.
Now I don't feel the change from each dose so much. This might be because my levels have risen and each daily increment is not so significant. I don't think it is because of tolerance.
I know what the dopaminergic feeling is....this is different.....I felt younger, just a bit.
I have found it easier to lower my dose of painkillers, benzos and alcohol. By 25% or so.
I know the dopaminergic feeling. With NMM I felt like I did when I was younger, nothing dramatic, but nevertheless real for me.
Posted by beckett2 on September 1, 2017, at 17:12:20
In reply to Re: Is vitamin B3 an effective alternative to NAD+?, posted by sigismund on September 1, 2017, at 2:44:54
> >how does it feel?
>
> Well.......to begin with it was really noticeable. I would describe it as a kind of euphoria.....but that is for me and I am in poor health in my mid 60s, dragging myself around......so I wondered if my levels of NAD+ were low.
>
> Now I don't feel the change from each dose so much. This might be because my levels have risen and each daily increment is not so significant. I don't think it is because of tolerance.
>
> I know what the dopaminergic feeling is....this is different.....I felt younger, just a bit.
>
> I have found it easier to lower my dose of painkillers, Extension and alcohol. By 25% or so.
>
> I know the dopaminergic feeling. With NMM I felt like I did when I was younger, nothing dramatic, but nevertheless real for me.
Hello again sigi :) You take Revgenetic's NMN, which has 50mg of NMN which claims to cross the blood brain barrier. Would you considering taking Life Extension's Niagen as well?
Posted by sigismund on September 1, 2017, at 17:24:33
In reply to Re: Is vitamin B3 an effective alternative to NAD+? » sigismund, posted by beckett2 on September 1, 2017, at 17:12:20
> Would you considering taking Life Extension's Niagen as well?
Yeah hi
I read that NR was converted into NMN and also vice versa....so yes, I wondered if taking both might be a good idea.
I might do that.
Posted by sigismund on September 8, 2017, at 2:51:58
In reply to Re: Is vitamin B3 an effective alternative to NAD+?, posted by sigismund on September 1, 2017, at 17:24:33
https://academic.oup.com/jes/article/1/7/816/3827720/Targeting-NAD-in-Metabolic-Disease-New-Insights
Posted by SLS on September 8, 2017, at 20:35:38
In reply to Re: Is vitamin B3 an effective alternative to NAD+?, posted by sigismund on September 8, 2017, at 2:51:58
> https://academic.oup.com/jes/article/1/7/816/3827720/Targeting-NAD-in-Metabolic-Disease-New-Insights
That's a good article. However, it doesn't address which supplements are best suited to raise NAD+ at the cellular level. Any opinions?
- Scott
Posted by Lamdage22 on September 9, 2017, at 0:49:29
In reply to Re: Is vitamin B3 an effective alternative to NAD+? » sigismund, posted by SLS on September 8, 2017, at 20:35:38
What is a natural or healthy daily NAD+ dosage? Is NAD+ essential? Meaning does the body need an external intake of it?
Is there a blood test?
Posted by sigismund on September 14, 2017, at 19:17:02
In reply to Re: Is vitamin B3 an effective alternative to NAD+?, posted by Lamdage22 on September 9, 2017, at 0:49:29
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651433/pdf/nihms-96557.pdf
Posted by beckett2 on November 16, 2017, at 23:00:34
In reply to NAD+ Does anyone take this to prevent aging?, posted by SLS on August 7, 2017, at 20:59:15
I started 250 mg daily, and I'm feeling pretty good. This could be attributed to a number of things, including simple cycling.
I'll keep you posted if I discern an effect. This would likely be a long term course, regarding aging. My mind has been a bit clearer. Again, that could be cycling. The loss of a sharp (or at least it was sharper) mind and vocabulary is the very worst side effect of chronic depression. I read well enough-- it's my speech :(
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Dr. Bob is Robert Hsiung, MD,
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