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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by linkadge on November 12, 2007, at 16:28:41
Hi, I am giving the herb kudzu a try. According to research it is a 5-ht1a agonist, 5-hta/c agonst, and some serotonin reuptake inhibition(?).
Anyhow, the proof is in the pudding, we'll see.
Linkadge
Posted by nolvas on November 12, 2007, at 18:20:30
In reply to Giving Kudzu a try, posted by linkadge on November 12, 2007, at 16:28:41
Kudzu Contains these Substances references
(mg of Substance per 100 Grams)
Polyphenols: Isoflavonoids: Daidzein 95 - 185
Daidzin
Genistein 12.6 - 31.7
Puerarin
Biochanin A 1.4
Formononetin 7.09
Triterpene Glycosides: SA1 SA2
SA3
Isoflavonoids normally comprise 1.77% to 12.0% of Kudzu root. Puerarin is present in higher quantities than the other Isoflavones, followed by Daidzin and Daidzein.
Although Equol is not a constituent of Kudzu, consumption of Kudzu may increase Equol levels via the Daidzein content of Kudzu converting to Equol within the body. Kudzu contains higher levels of Daidzein than Soybeans.
Kudzu is supposed to be a very good hangover cure as well due to it eliminating acetaldehyde from the body, the chemical that causes hangovers.
Posted by bleauberry on November 16, 2007, at 19:40:40
In reply to Re: Giving Kudzu a try, posted by nolvas on November 12, 2007, at 18:20:30
>
> Kudzu is supposed to be a very good hangover cure as well due to it eliminating acetaldehyde from the body, the chemical that causes hangovers.Wow, if that is true, that is huge news to a great many people suffering from candida, mercury or lead toxicity, gluten intolerance, food sensitivities, chemical sensitivies, allergies. When candida overgrow in the intestine they spill toxins into the blood system. The primary toxin they spill is acetyldehyde, resulting in systems of brain fog, fatigue, achinees, and depression. All of the above conditions either directly or indirectly cause acetyldehde to flood the brain. It is quite neurotoxic. It binds to existing serotonin and dopamine and contaminates them, making them very ineffective at their jobs. Thus a possible explanation for bad reactions to psych drugs. It would not surprise me at all if a great many treatment resistant patients are actually under the influence of acetyldehyde.
The only way I have heard of to get the body to break down acetyldehyde and excrete it, especially from tissue storage, is to take very high doses of both molybdenum and vitamin B5.
So if Kudzu does that, like I said, that is potentially huge news to a ton of people who aren't even aware of where their lousy feelings are coming from. So many of them think it is a neurotransmitter deficiency. Hangover anyone?
Posted by linkadge on November 17, 2007, at 20:15:24
In reply to Re: Giving Kudzu a try, posted by bleauberry on November 16, 2007, at 19:40:40
I don't like Kudzu. It just makes me feel wierd and have some minor/subtle visual hallucinations.
Linkadge
Posted by nolvas on November 17, 2007, at 22:51:07
In reply to Re: Yuck, posted by linkadge on November 17, 2007, at 20:15:24
Kudzu also has benzodiazepine antagonist properties. It would be a guess but I imagine it could make anxiety worse for some people?
Posted by linkadge on December 16, 2007, at 20:54:40
In reply to Re: Yuck, posted by nolvas on November 17, 2007, at 22:51:07
Yeah thats strange seeing as it is marketed for achohol withdrawl.
Linkadge
Posted by cache-monkey on January 29, 2008, at 15:17:18
In reply to Re: Yuck » nolvas, posted by linkadge on December 16, 2007, at 20:54:40
> Yeah thats strange seeing as it is marketed for achohol withdrawl.
>
> LinkadgeThe effects of another BZD antagonist, flumazenil, on anxiety are mixed. I've seen a study showing that it potentially exacerbates anxiety in panic disorder and another one that shows anxiolytic effects in high state-anxiety and anxiogenic effects in low state-anxiety.
The latter paper argues that it "normalizes" BZD receptor function, "returning it to a baseline state". This, I think, is why it has been useful for certain aspects of alchohol and BZD withdrawal. If given before withdrawal, it increases the sensitivity of sub-sensitized receptors, reducing tolerance. If given after BZD withdrawal there are transient negative effects (dizziness, lightheadedness) during administration, but medium-run positive effects on anxiety.
So maybe this has something to do with your BZD receptors being in an irregular conformation. Have you been on BZDs in the past?
Or maybe it has to do with 5-HT1 agonism? Also, while the main isoflavoinoid (puerarin) antagonizes the 5-HT2A/C receptors, who knows about the other constituents.
Let us know if you try kudzu again.
Best,
cache-monkey
This is the end of the thread.
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