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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by NARCOLEPTIC on June 28, 2005, at 12:31:27
There are several findings on the action of magnesium ions supporting their possible therapeutic potential in affective disorders. Examinations of the sleep-electroencephalogram (EEG) and of endocrine systems point to the involvement of the limbic-hypothalamus-pituitary-adrenocortical axis as magnesium affects all elements of this system. Magnesium has the property to suppress hippocampal kindling, to reduce the release of adrenocorticotrophic hormone (ACTH) and to affect adrenocortical sensitivity to ACTH. The role of magnesium in the central nervous system could be mediated via the N-methyl-D-aspartate-antagonistic, gamma-aminobutyric acidA-agonistic or a angiotensin II-antagonistic property of this ion. A direct impact of magnesium on the function of the transport protein p-glycoprotein at the level of the blood-brain barrier has also been demonstrated, possibly influencing the access of corticosteroids to the brain. Furthermore, magnesium dampens the calciumion-proteinkinase C related neurotransmission and stimulates the Na-K-ATPase. All these systems have been reported to be involved in the pathophysiology of depression. Despite the antagonism of lithium to magnesium in some cell-based experimental systems, similarities exist on the functional level, i.e. with respect to kindling, sleep-EEG and endocrine effects. Controlled clinical trials examining the effect of Mg in affective disorder are warranted.
Posted by SLS on June 28, 2005, at 12:31:27
In reply to Magnesium and affective disorders., posted by NARCOLEPTIC on June 25, 2005, at 13:16:31
I guess the question becomes whether or not supranutritional dosages of magnesium translate into higher levels at the sites of physiological relevence. Perhaps magnesium supplements improve the conditions of only those who are deficient in magnesium to begin with.
You should pay a visit to the PB Alternative board if you haven't already. You can put out feelers as to how many people have tried magnesium supplements and what the results were. I tried it. Nada.
- Scott
Posted by SLS on June 28, 2005, at 12:31:27
In reply to Re: Magnesium and affective disorders., posted by SLS on June 25, 2005, at 14:02:52
I forgot.
One of my doctors at the NIH told me that he thought there might be something going on with the actions of magnesium that contributed to depression.
- Scott
Posted by linkadge on June 28, 2005, at 12:31:27
In reply to Re: Magnesium and affective disorders., posted by SLS on June 25, 2005, at 14:05:03
IN one study intravenious magnesium had an antimanic effect, in manic patients.
Linkadge
Posted by Phillipa on June 28, 2005, at 12:31:27
In reply to Re: Magnesium and affective disorders., posted by linkadge on June 25, 2005, at 17:51:26
It's supposed to act as a relaxant. And Larry's not back. Fondly, Phillipa
Posted by linkadge on June 28, 2005, at 12:31:28
In reply to Re: Magnesium and affective disorders., posted by Phillipa on June 25, 2005, at 20:19:04
It does act this way, as a relaxant. Essentially, it has an overall dampening effect on glutamatergic neurotransmission.
In times of stress, the two things most readaly lost are (I believe) magnesium and vitamin C.
Not terrably surprisingly, vitamin C, and magnesium serve as a basis to many peoples alternative treatment for bipolar disorder.
Somtimes, when my antidepressant appeared to poop out. I would take a medication holliday in conjunction with time released vitamin c, and time released magnesium.
After these "hollidays" I felt I had a lot more stress buffer. You know, that feeling of having a bit of a bubble around you, and your problems.
This is just my experience though.
Linkadge
This is the end of the thread.
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