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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by linkadge on January 19, 2005, at 19:14:54
I had a good responce to FO-TI. It supposedly has marked MAO-B inhibiting properties.
I recently read a case report of liver failure associated with its use. Do you know anything on the safety of this herb ??
Linkadge
Posted by gromit on February 4, 2005, at 23:20:57
In reply to Larry - D'ya know anything about FO-TI ??, posted by linkadge on January 19, 2005, at 19:14:54
> I had a good responce to FO-TI. It supposedly has marked MAO-B inhibiting properties.
I tried it by itself and also tried it with tyrosine, it didn't seem to have any effect. Maybe DLPA instead of tyrosine would make a difference. I'm kind of bummed because I've been wanting to try the Selegiline/DLPA combo, and after reading your first post about Fo-Ti I thought it might give me a hint of what that would be like. Maybe I didn't give it a long enough trial though or maybe the dose was too low. How long did you take it before you noticed it's effects? At what dose?
TIA,
Rick
Posted by Larry Hoover on February 14, 2005, at 17:30:49
In reply to Larry - D'ya know anything about FO-TI ??, posted by linkadge on January 19, 2005, at 19:14:54
> I had a good responce to FO-TI. It supposedly has marked MAO-B inhibiting properties.
The substance in Fo-ti (Polygonum multiflorum) that inhibits MAO-B is called emodin. See: http://www.paper.edu.cn/scholar/download.jsp?file=konglingdong-4
As herbs go, it's pretty potent. Hard to know what it's really like to use it, though. Herbs are complex.
> I recently read a case report of liver failure associated with its use. Do you know anything on the safety of this herb ??
>
> LinkadgeThe reports of liver failure are associated with contaminants? in one particular brand of proprietary Chinese medicine prepared from this root. It's not clear if the root is to blame, or the preparation itself. In any case, cessation of the herbal medicine cleared up the liver problems.
There is clear evidence that Polygonum multiflorum extract improves liver glutathione status, so a finding of liver toxicity is not expected.
Lar
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