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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Dr. Bob on July 17, 2004, at 3:01:11
In reply to 5-htp to boost serotonin, posted by Marty mc Fly on July 15, 2004, at 19:38:47
Posted by Marty mc Fly on July 15, 2004, at 19:38:47
> After some research I decided to use 5-htp as an anti-poopout agent for clomipramine to boost some extra serotonin. I started with 100 mg and worked my way up to 300 mg in 3 divided doses of 100 mg over the day. The only effect I have after 2 months of consistent use is severe nausea every day, even with the divided dose and no antidepressant effect whatsoever.
> I have taken in with and without vitamine B6 and magnesium, 3 hours after a meal, with orange juice.
>
> What am I doing wrong ?
> Are there ways to improve effectiveness of 5-htp or should I use another agent to increase effectiveness of clomipramine ?
>
> Thanx a lot in advance !
>
> Marty
Posted by KaraS on July 17, 2004, at 15:31:02
In reply to 5-htp to boost serotonin « Marty mc Fly, posted by Dr. Bob on July 17, 2004, at 3:01:11
> Posted by Marty mc Fly on July 15, 2004, at 19:38:47
>
> > After some research I decided to use 5-htp as an anti-poopout agent for clomipramine to boost some extra serotonin. I started with 100 mg and worked my way up to 300 mg in 3 divided doses of 100 mg over the day. The only effect I have after 2 months of consistent use is severe nausea every day, even with the divided dose and no antidepressant effect whatsoever.
> > I have taken in with and without vitamine B6 and magnesium, 3 hours after a meal, with orange juice.
> >
> > What am I doing wrong ?
> > Are there ways to improve effectiveness of 5-htp or should I use another agent to increase effectiveness of clomipramine ?
> >
> > Thanx a lot in advance !
> >
> > Marty
>Marty,
I meant to respond to your posts on the other board today but Dr. Bob redirected you first. I was very surprised that no one over there was alarmed at the possibility of serotonin syndrome. (Larry, of course, was on it right away once he heard about the clomipramine.) Though clomipramine does not have exclusively serotonergic activity, it does have strong 5-HT reuptake inhibition. You are playing with fire here. MUCH TOO MUCH SEROTONIN!! That is probably why you feel so sick. This can be DEADLY! Literally. (You may already know this but I wanted to make sure.) You might want to contact Linkadge on the regular PB board who landed in the hospital by combining too large of a dosage of an SSRI with a serotonergic herb.Please be careful.
Kara
Posted by Marty mc Fly on July 18, 2004, at 9:19:28
In reply to Re: 5-htp to boost serotonin, posted by KaraS on July 17, 2004, at 15:31:02
Hi Kara,
Thanks for alarming me ! I am however well aware of the dangers of serotonin and especially the serotonin syndrome. Clomipramine didn't have much of an effect anymore so an option was to augment it with for example, 5-htp.
I know of a lot of symptomes of serotonin syndrome such as euphoria, drowsiness, sustained rapid eye movement, overreaction of the reflexes, rapid muscle contraction, clumsiness, restlessness, feeling drunk and dizzy, shivering, diarrhea. etc. But I didn't think the stomach nausea I experienced was a symptome. Anyhow, I wil stop using 5-htp, cause it didn't give me any relief anyhow. Thanks again for your concern.Marty
Posted by KaraS on July 18, 2004, at 14:53:24
In reply to Re: 5-htp to boost serotonin » KaraS, posted by Marty mc Fly on July 18, 2004, at 9:19:28
> Hi Kara,
>
> Thanks for alarming me ! I am however well aware of the dangers of serotonin and especially the serotonin syndrome. Clomipramine didn't have much of an effect anymore so an option was to augment it with for example, 5-htp.
> I know of a lot of symptomes of serotonin syndrome such as euphoria, drowsiness, sustained rapid eye movement, overreaction of the reflexes, rapid muscle contraction, clumsiness, restlessness, feeling drunk and dizzy, shivering, diarrhea. etc. But I didn't think the stomach nausea I experienced was a symptome. Anyhow, I wil stop using 5-htp, cause it didn't give me any relief anyhow. Thanks again for your concern.
>
> Marty
>
>
OK, Good. I'm glad you were aware and knew what you were doing. Some people who post aren't.
Take care,
Kara
This is the end of the thread.
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