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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by loolot on October 29, 2003, at 18:43:50
I am wondering if straterra will make my body produce more cortisol or less? Anyone know?
Posted by Robert Fairburn on October 30, 2003, at 9:34:09
In reply to Do NE uptake inhibitors reduce or promote cortisol, posted by loolot on October 29, 2003, at 18:43:50
I would like to know myself, however I would assume that they reduce cortisol levels. Mind due Im just guessing here
Regards Robert
> I am wondering if straterra will make my body produce more cortisol or less? Anyone know?
Posted by loolot on October 30, 2003, at 11:53:28
In reply to Re: Do NE uptake inhibitors reduce or promote cortisol, posted by Robert Fairburn on October 30, 2003, at 9:34:09
> I would like to know myself, however I would assume that they reduce cortisol levels. Mind due Im just guessing here
Hi Robert
What would lead you to come to that theory? Curious
Posted by loolot on October 30, 2003, at 12:30:01
In reply to Re: Do NE uptake inhibitors reduce or promote cort » Robert Fairburn, posted by loolot on October 30, 2003, at 11:53:28
Seems like NE uptake inhibiors stimulates cortisol.
Im confused about cortisols role in depression. I know that there are high cortisol levels in depressed people, but does that include atypical depression and people with accompanying autoimmune diseases? Anyone?
Posted by Robert Fairburn on October 30, 2003, at 14:35:15
In reply to NE/cortisol- found a study, posted by loolot on October 30, 2003, at 12:30:01
Yes that is interesting
However not ever one suffers from high cortisol levels, however I do think that High cortisol is bad for you
Regards Robert
Posted by NoMotic on October 31, 2003, at 17:28:51
In reply to Re: NE/cortisol- found a study, posted by Robert Fairburn on October 30, 2003, at 14:35:15
Cortisol is bad for depression. Even people who's depression is caused by excess cortisol theoretically could benefit from NE reuptake inhibitors and SSRI's, both of which ACUTELY raise cortisol. The problem in depression, in my opinion, isn't lack of Norepinephrine or Serotonin. However, raising those transmitters can alleviate depression. After several weeks of NRI's / SSRI's, those stress hormones will eventually level out and actually reregulate I THINK (dont quote me on this - ) to below levels they originally were - which is part of the antidepressant response. These meds do acutely raise cortisol - and in fact, these meds can acutely cause an increase in anxiety, but this all levels out and things improve as treatment progresses.
Anyway, I think that some forms of depression involve raised stress hormones which indirectly lower NE and 5-HT. But strangely, raising NE and 5-HT also raises stress hormone levels... which is cause for the acute feelings of anxiety for SSRI's or NRI's... yet raising stress hormones via anti-depressants is probably a side effect that levels itself out after receptor reregulation. Does that help slightly? I can't provide complete answers, but maybe a little.
Posted by loolot on November 1, 2003, at 11:10:25
In reply to I think it's because..., posted by NoMotic on October 31, 2003, at 17:28:51
Yeah, this meakes sense. I actually worry that the reason that eventually cortisol goes down id ebcause your own adrenal shuts off. Does this cause damage to the adrenal gland over time?
The thing is, in atypical depressives, some tests show that adrenal glands dont produce enough cortisol. Its all really confusing. I am mostly worried about the long term implications, though
This is the end of the thread.
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