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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by PeterMartin on January 15, 2023, at 1:37:33
Has anyone given inositol a try for anxiety (or depression)? I had some that I never gave a trial of and took some last night to try to quell some anxiety post ritalin. It did help and pretty quickly. I'm just not sure if there's a real risk of mania or depression being that I'm BP1.
If anyone has any experiences I'd be interested in hearing them.
Thanks!
Posted by PeterMartin on January 15, 2023, at 1:40:33
In reply to inositol?, posted by PeterMartin on January 15, 2023, at 1:37:33
Oh, I should mention that I took it as half a pill (250mg) as opposed to powder. I took 2.5 pills today as the anxiety w/ ritalin comes and goes - it's so inconsistent. I do seem to get a tad bit spacey when it kicks in (20min to 60min) but earlier today I was feeling pretty good.
My other meds:
Marplan 60
Lamictal 200 (taro but I'm always switching generics ugh)
Seroquel 25 (bedtime for sleep)
Mounjaro (GLP-1 / GIP agonist for weight loss)
Posted by Lamdage22 on January 15, 2023, at 2:53:06
In reply to Re: inositol?, posted by PeterMartin on January 15, 2023, at 1:40:33
What has deterred me is the humongous dosage that studies suggest. So you are saying you feel results with low dose?
Posted by PeterMartin on January 15, 2023, at 4:05:32
In reply to Re: inositol?, posted by Lamdage22 on January 15, 2023, at 2:53:06
> What has deterred me is the humongous dosage that studies suggest. So you are saying you feel results with low dose?
Yea, it's only been a 2 days, but it definitely does something and pretty quickly. This is the product I have (ordered it back in spring of 2021 but ended up switching meds instead): https://www.amazon.com/Standard-Process-Cardiovascular-Supplement-Processing/dp/B002D2RXIK
I'll see how it goes, but def want to take it slow as some studies show inositol is elevated during manic states. I had my first episode of real (split from reality) mania in 7 years in October after initiating Buspar. The depression since has been difficult, but I obviously don't want to lose it again....
Posted by SLS on January 15, 2023, at 11:24:04
In reply to inositol?, posted by PeterMartin on January 15, 2023, at 1:37:33
> Has anyone given inositol a try for anxiety (or depression)? I had some that I never gave a trial of and took some last night to try to quell some anxiety post ritalin. It did help and pretty quickly. I'm just not sure if there's a real risk of mania or depression being that I'm BP1.
>
> If anyone has any experiences I'd be interested in hearing them.
>
> Thanks!I apologize for writing stuff that doesn't directly apply to your question.
The only comment I can offer you is that Robert M. Post, MD of the National Institutes of Health (NIH) still includes inositol in the treatment of mood disorders, including treatment-resistant depression. He still has a private practice in Chevy-Chase, Maryland, but he charges $500 per hour for a phone consultation. Truthfully, I was not at all impressed with the results of a friend's phone consultation with him. My friend would best be described as being somewhere along the bipolar spectrum. I think inositol would make a good adjunct to lithium in bipolar depression, and perhaps unipolar depression as well. For most of his career, Dr. Post has been most interested in treating bipolar illness with mood stabilizers and substances usually described as being "nutriceuticals".
As I see it, the problem with Dr. Post is that he still adheres to an old school of thought that doesn't allow for giving antidepressants to treat any kind of bipolar disorder. Of course, I don't think that this should be applied universally. Were I being treated by Dr. Post, I would be depressed for the rest of my days.
Given all of that, I think inositol is one of the nutriceuticals most likely to help treat depression. It is used by the body to manufacture inositol phosphates and phosphatase enzymes. They are integral in the stabilization of neuronal and vesicular membranes. They also act as part of the post-synaptic second-messenger system and also modulate neurotransmission by facilitating the rushing of calcium ions from into the cell. These t also has its own receptor from which second messengers and calcium ion influx are activated.
N-acetylcysteine (NAC) is another substance worth exploring.
- Scott
Posted by PeterMartin on January 15, 2023, at 12:19:34
In reply to Re: inositol?, posted by SLS on January 15, 2023, at 11:24:04
...
> N-acetylcysteine (NAC) is another substance worth exploring.
>
>
> - ScottThanks, Scott!!
I did give NAC a trial a few years ago and if anything it may have made me a bit flat. I wouldn't be beyond trying it again, but for some reason it was pulled completely from Amazon so it's more of a pain to order it (creature of habit).
Have you yourself tried Inositol? And do you have any thoughts about its potential to cause a manic switch?There are some recent studies on pub med that have found elevated levels of inositol in certain areas of the brain during the manic phase. Also, lithium treatment has been found to reduce levels of inositol in the brain.
I know this stuff is never that easy, and a lot of the data suggests it could be very helpful in BP. I just can't afford to put my GF through another bad experience with me losing it.
I did sleep really well last night though, and woke up motivated to get on the computer and do things I enjoy. Anhedonia is a big part of my illness right now, so I'm optimistic that inositol might be able to help me.
Posted by SLS on January 15, 2023, at 13:16:44
In reply to Re: inositol?, posted by PeterMartin on January 15, 2023, at 12:19:34
> ...
> > N-acetylcysteine (NAC) is another substance worth exploring.
> >
> >
> > - Scott
>
> Thanks, Scott!!
Unfortunately, I pissed-off the best person to answer your questions. Although I am beyond frustrated with his sabotaging his own treatment, Linkadge is a wealth of information.Try not to revisit treatments that you know don't work out of desperation. That's why it makes sense to explore as thoroughly as possible a treatment the first time. However, one must still consider the possibility that a previously-trialed drug might not work alone, but be essential in a successful drug combination treatment.
I don't remember if I tried inositol or not. I have a copy of the results of my friend's consultation with Robert Post. She has been diagnosed as having Bipolar Depression. He mentions inositol and a bunch of other non-drug substances. If I can find it, I'll list Post's suggestions.
I am interested to know what drugs you have taken that produced even the slightest of a positive response, regardless of how brief.
Do you want to see something funny? I might have missed a few.
adinazolam
agomelatine
alprazolam
amitriptyline
amoxapine
amphetamine
aripiprazole
asenapine
brexpiprazole
bromocriptine
bupropion
carbamazepine
cariprazine
chloral hydrate
chlorpromazine
clomipramine
clonazepam
clorgyline
desipramine
desvenlafaxine
dexmethylphenidate
doxycycline
duloxetine
escitalopram
fluoxetine
fluphenazine
gabapentin
idazoxan
iloperidone
imipramine
indalpine
isocarboxezid
ketamine
lamotrigine
levetiracetam
lisdexamfetamine
lithium
lorazepam
lurasidone
memantine
methylfolate
methylphenadate
mifepristone
milnacipran
minocycline
mirtazapine
moclobemide
modafinil
monocycline
naltrexone
nomifensine
nortriptyline
olanzapine
oxcarbazepine
paroxetine
pemoline
perphanazine
phenelzine
prazosin
pregabalin
protriptyline
quetiapine
reboxetine
risperidone
selegiline
sertraline
sibutramine
sulpiride
temazepam
thioridazine
thyroxine T4
tiagabine
topiramate
tranylcypromine
trazodone
triazolam
triiodothyronine T3
trimipramine
valproate
venlafaxine
vilazodone
viqualine
vortioxetine
zaleplon
ziprasidone
zolpidem
zonisamide
Maybe not so funny.
- Scott
Posted by Lamdage22 on January 15, 2023, at 14:40:04
In reply to Re: inositol? » PeterMartin, posted by SLS on January 15, 2023, at 13:16:44
NAC produced a mervellous mood improvement in me the first 2-3 days and then a pretty nasty worsening. I have no idea what is going on. If we only knew more about those brains of ours.
Posted by SLS on January 15, 2023, at 14:49:50
In reply to Re: inositol? » PeterMartin, posted by SLS on January 15, 2023, at 13:16:44
I hope this gives everyone surety that they haven't tried everything.
Can anyone with mathematical skills work out how many permutations there are for combining any 4 drugs as a treatment?
What about 5?
This was the logic that helped keep me going.
I know it is easy and compelling to think that you've tried everything. Let's see what a mathematician comes up with.
Would 1000 alternative combinations of 4 drugs give you hope. Maybe just a little?
Let me tell you from personal experience that it doesn't always work, but still...
I may have missed a few. Can you imagine assaulting your brain with all of these?
-------------
1982 - 2020adinazolam
agomelatine
alprazolam
amitriptyline
amoxapine
amphetamine
aripiprazole
asenapine
brexpiprazole
bromocriptine
bupropion
carbamazepine
cariprazine
chloral hydrate
chlorpromazine
clomipramine
clonazepam
clorgyline
desipramine
desvenlafaxine
dexmethylphenidate
doxycycline
duloxetine
escitalopram
fluoxetine
fluphenazine
gabapentin
idazoxan
iloperidone
imipramine
indalpine
isocarboxezid
ketamine
lamotrigine
levetiracetam
lisdexamfetamine
lithium
lorazepam
lurasidone
memantine
methylfolate
methylphenadate
mifepristone
milnacipran
minocycline
mirtazapine
moclobemide
modafinil
monocycline
naltrexone
nomifensine
nortriptyline
olanzapine
oxcarbazepine
paroxetine
pemoline
perphanazine
phenelzine
prazosin
pregabalin
protriptyline
quetiapine
reboxetine
risperidone
selegiline
sertraline
sibutramine
sulpiride
temazepam
thioridazine
thyroxine T4
tiagabine
topiramate
tranylcypromine
trazodone
triazolam
triiodothyronine T3
trimipramine
valproate
venlafaxine
vilazodone
viqualine
vortioxetine
zaleplon
ziprasidone
zolpidem
zonisamide
- Scott
Posted by SLS on January 15, 2023, at 23:19:50
In reply to inositol?, posted by PeterMartin on January 15, 2023, at 1:37:33
Hi.
N-Acetylcysteine (NAC):
https://bipolarnews.org/?p=4740
- Scott
Posted by undopaminergic on January 16, 2023, at 10:04:57
In reply to Re: inositol? » PeterMartin, posted by SLS on January 15, 2023, at 13:16:44
>
> Do you want to see something funny? I might have missed a few.
>
> adinazolam
> agomelatine
> alprazolamamisulpride.
> escitalopram
eszopiclone.
flumazenil.
> fluoxetine
> fluphenazine> imipramine
> indalpineindatraline.
> naltrexone
nitrazepam.
nitroglycerine.norcocaine.
paliperidone.
> valproate
vanoxerine.
> zolpidem
> zonisamidezopiclone.
>
>
> Maybe not so funny.Funny or not, it is impressive if that list was from the top of your mind.
I already know a few I missed, such as piracetam. I need associations in order to recall a lot of things I remember well.
-undopaminergic
Posted by SLS on January 16, 2023, at 10:58:48
In reply to Re: inositol? » SLS, posted by undopaminergic on January 16, 2023, at 10:04:57
Wow!
You've tried a bunch of things I never heard of. I can't wait to hit PubMed.
> Funny or not, it is impressive if that list was from the top of your mind.It wasn't. I created a list of what I remember taking and adding to it periodically.
- Scott
Posted by undopaminergic on January 17, 2023, at 9:33:05
In reply to Re: inositol? » undopaminergic, posted by SLS on January 16, 2023, at 10:58:48
> Wow!
>
> You've tried a bunch of things I never heard of. I can't wait to hit PubMed.
>As I mentioned elsewhere, I didn't realise it was a list of drugs you have actually *taken*. So I haven't used most of them. I just added a few that came to mind (by association) as I was reading your list.
-undopaminergic
Posted by SLS on January 17, 2023, at 19:33:17
In reply to Re: inositol? » SLS, posted by undopaminergic on January 17, 2023, at 9:33:05
> > Wow!
> >
> > You've tried a bunch of things I never heard of. I can't wait to hit PubMed.
> >
> As I mentioned elsewhere, I didn't realise it was a list of drugs you have actually *taken*.
I wish my list were much, much shorter.Here's the kicker. In 1996, all four of the drugs that have worked for me were available with the approval of lamotrigine (Lamictal). I could have been free of depression and had begun a new life at age 36 rather than age 62. 36 would have been a good age to wake up from the nightmare. That's a lot of sex could I have had.
- Scott
This is the end of the thread.
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