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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by SLS on August 25, 2022, at 13:45:06
Hi.
"The effect of bupropion augmentation of minocycline in the treatment of depression"
https://pubmed.ncbi.nlm.nih.gov/31342957/
Minocycline is an antibiotic that also reduces inflammation in the brain. It accomplishes this through suppressing the secretion of pro-inflammatory cytokines from microglial cells. Of course, it might do other thing. Minocycline does have significant antidepressant effects. It helped me for quite some time. However, I had to discontinue it because hyperpigmentation of the skin appeared on my feet and lower legs. This side effect didn't emerge until I had taken minocycline for almost a year.I haven't a clue as to how bupropion and minocycline might have a synergistic effect.
- Scott
Posted by linkadge on August 27, 2022, at 6:41:09
In reply to Another interesting combination treatment., posted by SLS on August 25, 2022, at 13:45:06
>I haven't a clue as to how bupropion and minocycline might have a synergistic effect.
I suppose the idea is that bupropion doesn't address microglial inflammation on its own. Some antidepressants are better in this regard than others.
The problem with brain inflammation is that it can significantly reduce the ability of neurotransmitters to do their work. I read a recent study that showed that by inducing brain inflammation by using lipopolysaccharide, synaptic responses to dopamine are significantly reduced.
Linkadge
Posted by undopaminergic on August 27, 2022, at 10:36:17
In reply to Re: Another interesting combination treatment., posted by linkadge on August 27, 2022, at 6:41:09
> >I haven't a clue as to how bupropion and minocycline might have a synergistic effect.
>
> I suppose the idea is that bupropion doesn't address microglial inflammation on its own. Some antidepressants are better in this regard than others.
>
> The problem with brain inflammation is that it can significantly reduce the ability of neurotransmitters to do their work. I read a recent study that showed that by inducing brain inflammation by using lipopolysaccharide, synaptic responses to dopamine are significantly reduced.
>
> LinkadgeWhat about corticosteroids and NSAIDS?
Incidentally, corticosteroids can induce a condition known as "steroid euphoria". But cortisol is reportedly bad for the brain, especially the hippocampus.
-undopaminergic
Posted by linkadge on September 3, 2022, at 13:04:00
In reply to Re: Another interesting combination treatment., posted by undopaminergic on August 27, 2022, at 10:36:17
Yeah, it's best if you can get something that selectively targets inflammation in the brain. You don't want to shut down inflammation everywhere. NSAIDs come with cardiac risks, for example.
Linkadge
This is the end of the thread.
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