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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 24 of 24. This is the beginning of the thread.
Posted by phidippus on January 18, 2020, at 20:30:30
Lumateperone affects multiple systems (serotonergic, dopaminergic and glutamatergic) in the central nervous system. It acts as a antagonist of 5HT2A 0.54nM receptor and modulates D1 4.1nM and D2 3.2nM dopamine receptors where it is a partial agonist at presynaptic and antagonist at postsynaptic receptors. Serotonin transporters at 3.3nM. Through the mTOR pathway, lumateperone augments both NMDA and AMPA activity. Because of its complex pharmacology, it is not clear which of these activities are primarily responsible for its antidepressive and antipsychotic activities.
Very interesting.
Posted by Lamdage22 on January 19, 2020, at 4:22:18
In reply to Caplyta, posted by phidippus on January 18, 2020, at 20:30:30
I wonder if I would get serotonin Syndrome. I am on Venlafaxine 37.5 and Trazodone 75. If it wasn't for that fact, I'd try it in a heartbeat. No weight gain, right? But it could have sexual sides because it is a Serotonin Reuptake Inhibitor.
Now that I have started studying, time goes by much faster. I am not lingering around anymore waiting for better drugs to come out. They just come out...
And I do think that this decade, there will be something helpful for me. Aloradine for social anxiety! Please, PLEASE be good! It's not that far away from coming out I think!
Posted by Lamdage22 on January 19, 2020, at 4:33:34
In reply to Re: Caplyta, posted by Lamdage22 on January 19, 2020, at 4:22:18
I avoid many social situations... I'm not trying to become a politician or anything but I sure would like to go out into the world and connect with people to some degree. Living a life of solitude here...
Posted by undopaminergic on January 19, 2020, at 8:40:24
In reply to Re: Caplyta, posted by Lamdage22 on January 19, 2020, at 4:22:18
> I wonder if I would get serotonin Syndrome. I am on Venlafaxine 37.5 and Trazodone 75. If it wasn't for that fact, I'd try it in a heartbeat. No weight gain, right? But it could have sexual sides because it is a Serotonin Reuptake Inhibitor.
>Your dose of both these drugs is so low that I wouldn't worry the slightest about serotonin syndrome. In any case, life-threatening serotonin toxicity (ST) is exceedingly rare with only reuptake inhibitors. As a precaution, though, it may be a good idea to have some cyproheptadine (Periactin) (CHD) at hand as an antidote. Actually, now it occurs to me that trazodone blocks serotonin 5-HT2A receptors, which is the same action through which CHD works as an antidote to ST.
-undopaminergic
Posted by greg rizzo on January 19, 2020, at 12:28:15
In reply to Re: Caplyta, posted by undopaminergic on January 19, 2020, at 8:40:24
Thought was interesting read about on many other sites. YES-illegal to buy the musrooms but not illegal to buy a 'grow kit.'
_______________________________________________
INTERESTING 'MAGIC MUSROOM' STUDIES FOR TRD DEPRESSION --Staines October 26, 2018
-----------------------------------------------
Magic mushroom drug could be depression breakthrough, says FDA Richard Staines.
The liberty cap mushroom, notoriously used illegally as a psychoactive drug, could be the inspiration for a new therapy for depression according to the US drug regulator. Colorado and a few other states have already decriminalized uhe use of magic mushrooms.Mental health drug specialist COMPASS Pathways said that the FDA has designated the chemical psilocybin, which causes psychoactive effects in those eating magic mushrooms such as Psilocybe semilanceata, as a Breakthrough Therapy in treatment-resistant depression.
The FDA gives the designation to drugs where evidence demonstrates they could be a substantial improvement over available therapies for serious or life-threatening diseases.
Drugs given the designation are hastened through the development process by the FDA, which can grant a faster six-month review if it feels the evidence is still compelling once trials are completed.The company said in a statement that the designation is a significant milestone for psilocybin therapy and psilocybin research, after many years of research by teams in the US, the UK and Switzerland.
The Heffter Research Institute was the first to fund research in this field, and supported early studies at Johns Hopkins University, New York University, and Harbor-UCLA Medical Center.
In the UK, the Medical Research Council backed the proof-of-concept study of psilocybin for treatment-resistant depression at Imperial College London.
COMPASS is now running the first large-scale psilocybin therapy clinical trial for treatment-resistant depression, which will take place in Europe and North America over the next year or so.
The company said treatment-resistant depression affects approximately 100 million people around the world.The FDAs decision could prove a bureaucratic headache as psilocybin is deemed a highly illegal schedule 1 drug in the US, with a high potential for abuse and no currently accepted medical use but successful studies could change their approval decision
George Goldsmith, executive chairman, COMPASS Pathways, said: This is great news for patients. We are excited to be taking this work forward with our clinical trial on psilocybin therapy for treatment-resistant depression. The FDA will be working closely with us to expedite the development process and increase the chances of getting this treatment to people suffering with depression as quickly as possible.
Posted by undopaminergic on January 19, 2020, at 12:44:25
In reply to MAGIC MUSROOM FDA TEST FOR TRD depression, posted by greg rizzo on January 19, 2020, at 12:28:15
> Thought was interesting read about on many other sites. YES-illegal to buy the musrooms but not illegal to buy a 'grow kit.'
> _______________________________________________
> INTERESTING 'MAGIC MUSROOM' STUDIES FOR TRD DEPRESSION --Staines October 26, 2018
> -----------------------------------------------That is interesting, but I suggest that when you change the topic completely, as in this case, you start a new thread.
See this page:
https://www.dr-bob.org/babble/index.html
and near the bottom, under the heading "Start a new thread", there's a button you can click on.-undopaminergic
Posted by greg rizzo on January 19, 2020, at 12:50:31
In reply to Re: MAGIC MUSROOM FDA TEST FOR TRD depression, posted by undopaminergic on January 19, 2020, at 12:44:25
HAHA--TOO FUNNY. I predicted to my friends over here that you would be the first to respond as well as have the first to have a critcism!
Like there's never been a topic change within the same thread.Do me a favor and don't respond to my posts any further.
Posted by undopaminergic on January 19, 2020, at 13:02:47
In reply to Re: MAGIC MUSROOM FDA TEST FOR TRD depression, posted by greg rizzo on January 19, 2020, at 12:50:31
> HAHA--TOO FUNNY. I predicted to my friends over here that you would be the first to respond as well as have the first to have a critcism!
>You said you were a newbie. I'm trying to offer constructive criticism. Your (new) topic will actually get more exposure with a thread of its own. Do your topic a favour, if you care for it.
I'm the first to respond to a lot of posts, since I am currently not doing anything else that is more important.
> Like there's never been a topic change within the same thread.
Yes, it happens all the time, in passing, usually without us realising it's a topic change. In this case, however, you changed the title, which shows you were aware it was a new topic.
> Do me a favor and don't respond to my posts any further.
I will treat your posts the same as anyone else's.
-undopaminergic
Posted by Lamdage22 on January 19, 2020, at 13:27:49
In reply to Re: MAGIC MUSROOM FDA TEST FOR TRD depression » greg rizzo, posted by undopaminergic on January 19, 2020, at 13:02:47
Thank you undopaminergic. Let's please get back to topic.
Posted by phidippus on January 19, 2020, at 13:57:29
In reply to Re: Caplyta, posted by Lamdage22 on January 19, 2020, at 4:22:18
I doubt youu would get serotonin syndrome. Those are very low doses of Effexor and Trazadone.
Posted by phidippus on January 19, 2020, at 14:03:05
In reply to Re: MAGIC MUSROOM FDA TEST FOR TRD depression, posted by greg rizzo on January 19, 2020, at 12:50:31
You hijacked my thread with a completely unrelated topic. Please submit a new thread next time.
Posted by phidippus on January 19, 2020, at 14:12:18
In reply to MAGIC MUSROOM FDA TEST FOR TRD depression, posted by greg rizzo on January 19, 2020, at 12:28:15
What do magic mushrooms have to do with Caplyta. You hijacked my thread (in all caps I might add)). What is your problem?
Posted by Lamdage22 on January 19, 2020, at 21:46:32
In reply to Re: Caplyta » Lamdage22, posted by phidippus on January 19, 2020, at 13:57:29
I will keep an eye on it. The price is probably pretty hardcore. I managed to lose considerable weight on Seroquel and Zyprexa, so if i took it, I'd take it for the effects on negative symptoms and depression. I don't know why I suddenly am able to lose weight. Will it be covered by insurance for you US guys?
Posted by Lamdage22 on January 19, 2020, at 23:46:27
In reply to Re: Caplyta, posted by Lamdage22 on January 19, 2020, at 21:46:32
Serotonin without anorgasmia is something i am interested in.
Yeah, greg, we do need to keep some order here. This is a place where sensitive people seek refuge. Please dont write all caps, dont spam the board. And dont attack members. One thread about your Nardil concerns should be sufficient. I dont open a new thread every time i get no responses. Either people want to respond or they dont!
No offence!
Posted by undopaminergic on January 20, 2020, at 4:32:38
In reply to Re: Caplyta, posted by Lamdage22 on January 19, 2020, at 21:46:32
> I will keep an eye on it. The price is probably pretty hardcore.
And it's not approved in the EU yet. Or, maybe unilaterally in some European countries?
> I managed to lose considerable weight on Seroquel and Zyprexa, so if i took it, I'd take it for the effects on negative symptoms and depression. I don't know why I suddenly am able to lose weight.
>Did losing weight on these notorious appetite-stimulants require a lot of will power?
Drugs, including antipsychotics, affect different people differently, and even affect the same person differently at different times. Same thing with alcohol and vitamins and supplements.
I've been able to keep my weight in check despite clozapine. I've gone up and down at times. Going down generally does require a notable but not extreme amount of determination or will power. I exploit my laziness and refrain from going to the store, where I *would* buy sweets
-undopaminergic
Posted by Lamdage22 on January 20, 2020, at 5:47:24
In reply to Re: Caplyta, posted by undopaminergic on January 20, 2020, at 4:32:38
Not as much as I thought it would need. I am unsure of what has happened. I changed some things, I added two supplements. See this discussion: http://dr-bob.org/babble/20200104/msgs/1107677.html
My doctor thinks the European Drug Administration is in no way better than the FDA. So I could get Caplyta ahead of time if the price is not a total ripoff.
> Did losing weight on these notorious appetite-stimulants require a lot of will power?
>
> Drugs, including antipsychotics, affect different people differently, and even affect the same person differently at different times. Same thing with alcohol and vitamins and supplements.
>
> I've been able to keep my weight in check despite clozapine. I've gone up and down at times. Going down generally does require a notable but not extreme amount of determination or will power. I exploit my laziness and refrain from going to the store, where I *would* buy sweets
>
> -undopaminergic
>
Posted by greg rizzo on January 20, 2020, at 6:47:15
In reply to This thread is for Caplyta, not MAGIC MUSHROOMS... » greg rizzo, posted by phidippus on January 19, 2020, at 14:12:18
Posted new thread for mushrooms, wasn't aware of site rules. But sure seems like a lot of other topics than just Caplyta
Posted by greg rizzo on January 20, 2020, at 6:49:14
In reply to Re: MAGIC MUSROOM FDA TEST FOR TRD depression » greg rizzo, posted by phidippus on January 19, 2020, at 14:03:05
Done.
Posted by Lamdage22 on January 20, 2020, at 7:02:43
In reply to Re: This thread is for Caplyta, not MAGIC MUSHROOMS..., posted by greg rizzo on January 20, 2020, at 6:47:15
We all should make an effort for netiquette. Nobody is perfect. But i havent seen anybody do it like you did here.
> Posted new thread for mushrooms, wasn't aware of site rules. But sure seems like a lot of other topics than just Caplyta
Posted by undopaminergic on January 20, 2020, at 7:10:05
In reply to Re: Caplyta, posted by Lamdage22 on January 20, 2020, at 5:47:24
>
> My doctor thinks the European Drug Administration is in no way better than the FDA. So I could get Caplyta ahead of time if the price is not a total ripoff.
>I don't quite understand what you're saying. Would the EDA not being better than FDA help you get Caplyta ahead of time?
-undopaminergic
Posted by Lamdage22 on January 20, 2020, at 8:35:27
In reply to Re: Caplyta, posted by undopaminergic on January 20, 2020, at 7:10:05
It just means my dr is totally fine with prescribing fda approved drugs before they are approved in Europe.
Posted by undopaminergic on January 20, 2020, at 8:56:02
In reply to Re: Caplyta, posted by Lamdage22 on January 20, 2020, at 8:35:27
> It just means my dr is totally fine with prescribing fda approved drugs before they are approved in Europe.
>OK, but where do you get them from, if they aren't marketed in Europe? Do you buy from the US?
-undopaminergic
Posted by Lamdage22 on January 20, 2020, at 9:13:02
In reply to Re: Caplyta, posted by undopaminergic on January 20, 2020, at 8:56:02
Yes. Any pharmacy can import, if you show them a prescription!
Posted by Lamdage22 on January 21, 2020, at 14:31:03
In reply to Re: Caplyta, posted by Lamdage22 on January 19, 2020, at 23:46:27
Would insurances pay for it when it comes out? Mine would only at the point when it is marketed in Germany which could be a while. Is there any word out about the price?
This is the end of the thread.
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