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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Jeroen on August 31, 2018, at 10:50:21
what dose doxycycline to cross blood brain barrier
please help i only took 100 mg i think it was not enough to cross the brain blood barrier and treat this
Posted by bleauberry on September 1, 2018, at 9:13:20
In reply to what dose doxycycline to cross blood brain barrier, posted by Jeroen on August 31, 2018, at 10:50:21
Literature says about 400mg.
If you can get more doses or higher doses so you can do that, cool.
But if you can't, here's a way you can still do that. You can skip 4 days. Save the pills from those days. Then take 400mg on the 4th day, follow it with 200mg the 5th day, and finally 100mg the 6th day. The other days of the week skip.
Day 1 = 0mg
Day 2 = 0mg
Day 3 = 0mg
Day 4 = 400mg
Day 5 = 200mg
Day 6 = 100mg
Day 7 = 0mgThe days you skip will not slow down treatment. The bacteria grow slowly. It may actually improve treatment - it's called 'pulsing'. On the days you skip, the bacteria feel safe and they come out of hiding. Then you nuke them with 400mg. The next day your blood level will have dropped to 200mg (the 400mg is still half there, half gone). So when you take 200mg it brings it back up to 400mg in your blood system for another day. Bacteria who escape this time will go back into hiding. They will come back out of hiding on the days you skip. Repeat, repeat, repeat.
So if you can't get more pills, that's how you can work with what you've got.
> what dose doxycycline to cross blood brain barrier
> please help i only took 100 mg i think it was not enough to cross the brain blood barrier and treat this
Posted by Jeroen on September 1, 2018, at 16:33:54
In reply to Re: what dose doxycycline to cross blood brain barrier, posted by bleauberry on September 1, 2018, at 9:13:20
i have to take it daily bleauberry a high dose because minocycline can go trough the brain blood barrier so easy but has nasty side effects, so....
Posted by bleauberry on September 4, 2018, at 9:36:32
In reply to Re: what dose doxycycline to cross blood brain barrier, posted by Jeroen on September 1, 2018, at 16:33:54
> i have to take it daily bleauberry a high dose because minocycline can go trough the brain blood barrier so easy but has nasty side effects, so....
Well, no that's wrong. if you are talking about Doxy, you do not have to take it daily. You can skip 4 days, take 400mg on the 5th day, 200mg on the 6th day, 100mg on the 7th day, and most likely getting stronger effect than 100mg daily.
Mino hits more bacteria than Doxy does and so yes the side effects can be worse.
Posted by Jeroen on September 4, 2018, at 9:45:22
In reply to Re: what dose doxycycline to cross blood brain barrier, posted by bleauberry on September 4, 2018, at 9:36:32
Bleauberry i had no response too 100 mg will higher dose work like mino?
Posted by bleauberry on September 6, 2018, at 6:11:44
In reply to Re: what dose doxycycline to cross blood brain barrier, posted by Jeroen on September 4, 2018, at 9:45:22
Just because you can't feel a response doesn't mean it isn't doing its job. I would say maybe roughly 3/4 of the time we take antibiotics we don't feel they are doing anything. It's really only during the Herxheimer reactions that you feel it. Or the initial antidepressant effect you feel when you first start it. Other than those feelings, it is pretty much waiting game of time and persistence. The bacteria are constantly going into hiding, coming out of hiding, and you feel it when that happens. But most of the time they are inactive or dormant and that is why it takes so long to treat. Anecdotal clues suggest that they are really active about one week out of every month. That's usually around a full moon. But with me it was always around half moons. It might be an interesting eye-opener to start tracking how you feel on half and full moons. I would wager a bet you find a pattern there. That pattern ties into your antibiotic treatment and has a lot more to do with what you feel than the dosage of the medication does. 100mg is doing damage to the enemy.
> Bleauberry i had no response too 100 mg will higher dose work like mino?
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