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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by Hugh on July 4, 2018, at 9:56:56
One hallmark of depression and similar disorders is that tiny structures called neurites in the prefrontal cortex -- a critical brain region responsible for regulating fear response and reward -- shrivel up. These neurites play an important role in brain function as they span the junctions -- or synapses -- between individual neurons, enabling them to communicate with each other.
In their experiments, the scientists found that psychedelics increased both the growth of neurites and the number of connections between neurons. Some compounds, such as LSD, even proved to be more potent than ketamine in promoting neurite growth. This suggests that psychedelics have the potential to reverse some of the structural changes seen in the brains of people with mood disorders.
Complete article:
http://www.newsweek.com/psychedelics-may-physically-alter-structure-brain-972403
Posted by linkadge on July 4, 2018, at 11:28:58
In reply to Psychedelics may alter structure of the brain, posted by Hugh on July 4, 2018, at 9:56:56
There are many case reports that psychedelics (now, in addition to ketamine) can help depression / ocd.
psychedelics are probably cleaner than ketamine (in terms of brain targets). I wonder if the neurogenic effect is septate from the psychedelic effect.
Linkadge
Posted by Hugh on July 4, 2018, at 11:58:54
In reply to Re: Psychedelics may alter structure of the brain, posted by linkadge on July 4, 2018, at 11:28:58
Microdosing LSD at sub-psychedelic levels appears to be an effective treatment for depression.
Posted by sigismund on July 4, 2018, at 18:27:48
In reply to Re: Psychedelics may alter structure of the brain » linkadge, posted by Hugh on July 4, 2018, at 11:58:54
I thought it was pretty good. Attention to dose is important of course. Perhaps best to have a day of your choosing at your disposal.
Posted by linkadge on July 4, 2018, at 18:30:06
In reply to Re: Psychedelics may alter structure of the brain » linkadge, posted by Hugh on July 4, 2018, at 11:58:54
Interesting.
Our brains have a natural psychedelic (tryptamine) which is released during sleep in small quantities.
Interestingly, MAO inhibition raises the levels of tryptamine.
Linkadge
Posted by Hugh on July 6, 2018, at 1:14:42
In reply to Psychedelics may alter structure of the brain, posted by Hugh on July 4, 2018, at 9:56:56
Here's a video of Bill Maher interviewing Michael Pollan, author of the bestseller "How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence."
https://www.youtube.com/watch?v=mhC3L1ZKxHU
A video of a Michael Pollan talk:
Posted by Hordak on July 6, 2018, at 11:28:27
In reply to Re: Psychedelics may alter structure of the brain, posted by Hugh on July 6, 2018, at 1:14:42
> Here's a video of Bill Maher interviewing Michael Pollan, author of the bestseller "How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence."
>
> https://www.youtube.com/watch?v=mhC3L1ZKxHU
>
> A video of a Michael Pollan talk:
>
> https://www.youtube.com/watch?v=KuhmZSFvhL0Is it good, that book?
I always wanted to try LSD and Psilocybin.
Posted by linkadge on July 6, 2018, at 15:04:39
In reply to Re: Psychedelics may alter structure of the brain, posted by Hordak on July 6, 2018, at 11:28:27
I wonder to what degree the neurotrophic effect is linked to the psychedelic effect.
For example, LSD activates many serotonin receptors like 5-ht1a and dopamine receptors like d2. 5-ht1a agonists, like buspirone are neurotrophic, but buspirone is not psychedelic.
Linkadge
Posted by beckett2 on July 6, 2018, at 15:13:19
In reply to Psychedelics may alter structure of the brain, posted by Hugh on July 4, 2018, at 9:56:56
The author is the most charming, excellent writer.
Posted by Hugh on July 7, 2018, at 0:31:02
In reply to Re: Psychedelics may alter structure of the brain, posted by Hordak on July 6, 2018, at 11:28:27
Yes, Michael Pollan is an excellent writer.
Posted by Hugh on July 7, 2018, at 0:32:22
In reply to Re: Psychedelics may alter structure of the brain » Hugh, posted by beckett2 on July 6, 2018, at 15:13:19
> Have you seen this https://www.amazon.com/Change-Your-Mind-Consciousness-Transcendence/dp/1594204225/ref=sr_1_1?s=books&ie=UTF8&qid=1530907928&sr=1-1&keywords=michael+pollan+how+to+change+your+mind
>
> The author is the most charming, excellent writer.I agree.
Posted by Hugh on July 8, 2018, at 0:47:59
In reply to Re: Psychedelics may alter structure of the brain, posted by Hugh on July 6, 2018, at 1:14:42
Michael Pollan radio interview:
Michael Pollan's New Yorker article about psychedelics:
https://www.newyorker.com/magazine/2015/02/09/trip-treatment
This is the end of the thread.
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