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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by Lamdage22 on June 30, 2018, at 2:45:23
Hey babble friends,
a peer is taking Maprotilin and he says it does not influence his sex life at all. Might this be an option for me? Does it not cause anorgasmia? Does it prolong QT Interval?
Thanks
Posted by linkadge on June 30, 2018, at 9:09:29
In reply to Maprotilin, posted by Lamdage22 on June 30, 2018, at 2:45:23
Hi,
It is primarily a norepinephrine reuptake inhibitor, like nortriptyline or desipramine.
It probably feels more like nortriptyline, owing to its 5-ht2a and antihistamine effects.
The sexual side effects would probably be less than with SSRIs.
As far as cardiac effects, because it is a NRI, it could increase heart rate and/or blood pressure. From some google searching, it appears that QTc prolongation can be a side effect.
I'm not sure if you've tried nortriptyline. These two would likely be similar, with perhaps, a bit less risk of QTc with nortriptyline.Not 100% sure.
Linkadge
Posted by Lamdage22 on June 30, 2018, at 9:34:13
In reply to Re: Maprotilin, posted by linkadge on June 30, 2018, at 9:09:29
I worry because Maprotiline can worsen psychosis. I tried Nortriptyline. Made my package go flaccid.
Posted by Lamdage22 on June 30, 2018, at 9:34:34
In reply to Re: Maprotilin, posted by Lamdage22 on June 30, 2018, at 9:34:13
Plus anorgasmia :(
Posted by linkadge on June 30, 2018, at 11:49:30
In reply to Re: Maprotilin, posted by Lamdage22 on June 30, 2018, at 9:34:34
I wouldn't expect maprotiline to be dramatically different than nortriptyline. However, I have not taken maprotiline, so I can't directly compare.
All of the TCAs can worsen psychosis (as can many of the newer antidepressants too). An exception is amoxapine (not sure if you have tried this one). It is a strong antidepressant with antipsychotic qualities.
Linkadge
Posted by Lamdage22 on June 30, 2018, at 12:44:15
In reply to Re: Maprotilin » Lamdage22, posted by linkadge on June 30, 2018, at 11:49:30
I have not tried Amoxapine. Maybe i should
Posted by Hordak on June 30, 2018, at 14:49:53
In reply to Maprotilin, posted by Lamdage22 on June 30, 2018, at 2:45:23
Not that much different from Mianserin & Mirtazapine: strong antihistamine, potent 5HT2A and minor 5HT2C antagonism. NET varies...
Nortriptyline is superior ;=)
Posted by Christ_empowered on June 30, 2018, at 20:18:52
In reply to Re: Maprotilin, posted by Hordak on June 30, 2018, at 14:49:53
actually...a former shrink recommended amoxapine to me. I was scared because its a community/public mental health clinic, and I was already on a full dose of Abilify. These places are -notorious- for high dose neuroleptics, crazy cocktails, etc. so, I declined. However...
had she offered to taper the Abilify and use the amoxapine in place of it, I might have jumped at it. At high(ish) doses, there's limited data that shows good results in psychotic disorders, plus more pronounced benefits for mood and anxiety than, say, risperidone.
prolactin elevation is an issue. td is an issue. still, its considered somewhat 'atypical' by some 'experts,' so...there's that. i wouldn't take it with seroquel, not long term...
Posted by Lamdage22 on July 1, 2018, at 6:09:42
In reply to Re: Maprotilin, posted by Christ_empowered on June 30, 2018, at 20:18:52
Ok,
i am actually quite happy with my regimen. Changing it may make it worse
Posted by Lamdage22 on July 12, 2018, at 6:20:35
In reply to Re: Maprotilin, posted by linkadge on June 30, 2018, at 9:09:29
nortriptyline gave me anorgasmia and erectlie dysfunction
Posted by Hordak on July 12, 2018, at 12:19:49
In reply to Re: Maprotilin, posted by Lamdage22 on July 12, 2018, at 6:20:35
> nortriptyline gave me anorgasmia and erectlie dysfunction
Did you take it standalone?
Posted by Lamdage22 on July 12, 2018, at 12:55:11
In reply to Re: Maprotilin, posted by Hordak on July 12, 2018, at 12:19:49
no but i didnt have any of those sideeffects before nortriptyline.
Posted by Hordak on July 12, 2018, at 14:42:17
In reply to Re: Maprotilin, posted by Lamdage22 on July 12, 2018, at 12:55:11
> no but i didnt have any of those sideeffects before nortriptyline.
ahh, okay :=)
Did you try Clomipramine and/or the irreversible non-selective MAOI: Parnate/Nardil?
Posted by Lamdage22 on July 13, 2018, at 10:41:12
In reply to Re: Maprotilin » Lamdage22, posted by Hordak on July 12, 2018, at 14:42:17
I didnt try clomipramine and i did try MAOI. On maoi i went a little bit psychotic. Very resentful.
My doctor said if nortriptyline gives me sexual problems, then other tricyclics will, too.
Posted by Lamdage22 on July 15, 2018, at 1:38:29
In reply to Re: Maprotilin, posted by Lamdage22 on July 13, 2018, at 10:41:12
Mirtazapine made me aggressive. other than that i liked it. So maybe Maprotilin is worth a shot?
Posted by Lamdage22 on July 24, 2018, at 10:03:37
In reply to Re: Maprotilin, posted by Lamdage22 on July 15, 2018, at 1:38:29
This is the end of the thread.
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