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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by JohnBoy2000 on March 11, 2018, at 15:15:20
I've cycled through most classes of drugs, and the primary noradrenergic drugs.
Bupropion, reboxetine - and the final selective NA drug - Atomoxetine.
I've also had Lofepramine, which is like the UK's desipramine - being a prodrug to it.
I didn't respond well to it - could only tolerate lowest dose.However - the only real outstanding possible useful drug I haven't tried is MAPROTILINE.
Now - I've done a search on this forum on it - and there is some feedback; cause, it being an old drug, it is extremely difficult to find anything on it.
It's been taken off most markets - but it can be source from Belgium or something.
That being said - being a potent anti-histamine, it would have to be taken at night time.
I already take Mianserin, the alpha 2 blocker and NA drug, at night time.
Which may cause excessive night time activation - I couldn't take Lofepramine at night time for that reason.
Which leads me to my question.Does anyone have current or past experience with Maprotiline?
I've read in other posts that - its sedation can extend to the daytime?
I definitely don't find that with Mianserin.It is used in agitated depression, for its sedative properties, which is not what I would require it for.
Atomoxetine is great for energy for me - not at all sedating.
So - any insights?
Posted by JohnBoy2000 on March 11, 2018, at 15:33:19
In reply to Clinical profile of Maprotiline - Vs Strattera??, posted by JohnBoy2000 on March 11, 2018, at 15:15:20
Also - unbearable cardiac side effects from Lofepramine.
I don't get that on any other NA drugs.
Though Lofepramine is reputed to be the least severe cardiac drugs from the tricyclic class...?
Supposedly doesn't have mACh seid effects - but the cause of cardiac issues in my case - what else could it have come from.
That being said - Maprotiline supposedly doesn't have mACh binding - but similar effect profile - via "pseudo" mACh effects due to high NA activation.
Something like that?
Posted by ed_uk2010 on March 11, 2018, at 19:09:15
In reply to Re: Clinical profile of Maprotiline - Vs Strattera??, posted by JohnBoy2000 on March 11, 2018, at 15:33:19
>Though Lofepramine is reputed to be the least severe cardiac drugs from the tricyclic class...?
That's referring to the lower risk of cardiac conduction defects on lofepramine. As a result, serious arrhythmias are unlikely.
Lofepramine can still cause sinus tachycardia though, due to the noradrenergic increase in heart rate.
This is the end of the thread.
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