![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 8 to 32 of 32. Go back in thread:
Posted by Phillipa on April 26, 2016, at 17:48:07
In reply to Re: Brintellix question, posted by jonhed on April 26, 2016, at 16:50:55
Hi no Scott is not a doctor. This is a forum of people such as you and I. Scott and some others seem to have a greater understanding and knowledge of meds that most . No doctor is one here to read and prescribe meds. Just sharing of different responses to meds. You can babblemail me also. Phillipa
Posted by SLS on April 26, 2016, at 21:32:34
In reply to Re: Brintellix question, posted by g_g_g_unit on April 26, 2016, at 7:19:03
> However I have read some good things about Brintellix.
>
> Have you tried it?I wouldn't hesitate to try it except that I am currently taking Parnate, a MAOI.
- Scott
Posted by g_g_g_unit on April 27, 2016, at 0:51:59
In reply to Re: Brintellix question » g_g_g_unit, posted by SLS on April 26, 2016, at 21:32:34
> > However I have read some good things about Brintellix.
> >
> > Have you tried it?
>
> I wouldn't hesitate to try it except that I am currently taking Parnate, a MAOI.
>
>
> - ScottDo you know if any of its target sites might protect against developing akathisia on the drug?
Posted by jonhed on April 27, 2016, at 4:02:03
In reply to Re: Brintellix question » SLS, posted by g_g_g_unit on April 27, 2016, at 0:51:59
Am i wrong or isn't every substance that acts as a antagonist, regardless if we talk about noradrenalin, serotonin or dopamine, in risk of causing akathisia, just to a bigger or smaller extent?
Or is the risk smaller if it also, as brintellix does, act as a partial agonist?
I'm to interested in knowing that because i have said no in over a year to brintellix due to the fact that i already have some sorts of chronic akathisia from being over-medicated when i was younger. (it got to the point when my mom filed a report to the doctor, so it's an extreme case, these things doesn't happen alot think)
Posted by g_g_g_unit on April 27, 2016, at 4:22:36
In reply to Re: Brintellix question, posted by jonhed on April 27, 2016, at 4:02:03
> Am i wrong or isn't every substance that acts as a antagonist, regardless if we talk about noradrenalin, serotonin or dopamine, in risk of causing akathisia, just to a bigger or smaller extent?
>
> Or is the risk smaller if it also, as brintellix does, act as a partial agonist?
>
> I'm to interested in knowing that because i have said no in over a year to brintellix due to the fact that i already have some sorts of chronic akathisia from being over-medicated when i was younger. (it got to the point when my mom filed a report to the doctor, so it's an extreme case, these things doesn't happen alot think)I'm not sure. Noradrenaline antagonists (I guess you could throw beta-blockers, Prazosin etc. into that category) never induced akathisia in me. Dopamine antagonists certainly did.
I had akathisia that lasted for a year after discontinuing Mirtazapine. It was awful.
5-HT1a agonists and 5-ht3 antagonists both increase dopamine (and improve Parkinson's symptoms), but I can't find any evidence they would improve akathisia. My doctor is very pushy; I suppose if I try it, I would have to tread cautious and discontinue at any signs of its emergence.
Posted by SLS on April 27, 2016, at 7:17:42
In reply to Re: Brintellix question » SLS, posted by g_g_g_unit on April 27, 2016, at 0:51:59
> > > However I have read some good things about Brintellix.
> > >
> > > Have you tried it?> > I wouldn't hesitate to try it except that I am currently taking Parnate, a MAOI.
> Do you know if any of its target sites might protect against developing akathisia on the drug?Since Brintellix is not a SSRI nor a dopamine receptor antagonist, I would not expect akathisia to develop. Protective? I don't know. Brintellix is a full agonist at serotonin 5-HT1a receptors. I don't know how this might affect the risk of developing akathisia. However, Brintellix blocks an array of 5-HT receptors, including 5-HT7. This receptor is currently being looked at as a target for antidepressant drugs.
- Scott
Posted by FloydAS on April 27, 2016, at 10:34:37
In reply to Brintellix question, posted by g_g_g_unit on April 26, 2016, at 0:43:12
I've been on Brintellix over a year now. Prior to that I was on every variety dosage of Zoloft imaginable but never received sufficient therapeutic benefit.
I will say that I've felt myself the most while on Brintellix. For me personally, it just works. I'm at a very good level everyday without any type of mental fog whatsoever.
I dealt with significant agitation while on Zoloft and it was terrible during a 5 month period when I was on no medication. The agitation has fully resolved.
FYI...I'm on 20 mg of Brintellix daily and 40 mg of propranolol for essential tremor twice a day. I'm just about finished a very slow complete taper off Topamax that I've been on for many years as a migraine/chronic headache preventative. Topamax is known to frustrate cognition, so I wanted to see how improved I really am without any dumbing down by Topamax. Provided the migraines and headaches don't return to their previous frequency I will stay off the Topamax because I'm feeling better each day.
If you choose to try it, I hope it works for you. It has really been a good solution for me. And I have a lot of anxiety issues which Brintellix isn't really known to deal well with, but my anxiety is well under control too.
Good luck.
Posted by g_g_g_unit on April 27, 2016, at 10:58:10
In reply to Re: Brintellix question » g_g_g_unit, posted by FloydAS on April 27, 2016, at 10:34:37
> I've been on Brintellix over a year now. Prior to that I was on every variety dosage of Zoloft imaginable but never received sufficient therapeutic benefit.
>
> I will say that I've felt myself the most while on Brintellix. For me personally, it just works. I'm at a very good level everyday without any type of mental fog whatsoever.
>
> I dealt with significant agitation while on Zoloft and it was terrible during a 5 month period when I was on no medication. The agitation has fully resolved.
>
> FYI...I'm on 20 mg of Brintellix daily and 40 mg of propranolol for essential tremor twice a day. I'm just about finished a very slow complete taper off Topamax that I've been on for many years as a migraine/chronic headache preventative. Topamax is known to frustrate cognition, so I wanted to see how improved I really am without any dumbing down by Topamax. Provided the migraines and headaches don't return to their previous frequency I will stay off the Topamax because I'm feeling better each day.
>
> If you choose to try it, I hope it works for you. It has really been a good solution for me. And I have a lot of anxiety issues which Brintellix isn't really known to deal well with, but my anxiety is well under control too.
>
> Good luck.Thanks for sharing your experience; I'm really glad it's helping you.
I experienced significant anxiety and agitation on Zoloft as well; I never made it past 50mg.
Do you find that Brintellix interferes with your emotional range at all?
Posted by FloydAS on April 27, 2016, at 11:05:21
In reply to Re: Brintellix question » FloydAS, posted by g_g_g_unit on April 27, 2016, at 10:58:10
> Do you find that Brintellix interferes with your emotional range at all?
>No not really. If anything it has helped me regain some of that range. The initial week or two I was happy as a clam and very socially outgoing and talkative. The most I have really ever been. That has since leveled out but I feel I can experience joyful emotions more than I had been able to in the past.
I can't say much on the other end of the spectrum. I've been challenged enough to warrant feeling sad and depressed but gotten through it with no major problems lately. At least not falling into a total depression which is one of the major benefits of the drug.
Posted by ClearSkies on April 28, 2016, at 17:14:20
In reply to Brintellix question, posted by g_g_g_unit on April 26, 2016, at 0:43:12
> Hi there,
>
> Long time no see everyone.
>
> My doctor wants me to try Brintellix and I've been wondering if it's likely to induce anhedonia in the same way that SSRIs do? I know SSRIs work for some, but I always felt very numb, foggy and detached on them -- which made me feel stuck in a limbo and unable to engage with anything. I need to feel some responsiveness to stimuli and my environment. I believe Brintellix improves cognition, which is a plus.Not an answer to your question, but Brintillix made me suicidal and I had to do a quick, miserable taper off of it.
CS
Posted by Horse on April 30, 2016, at 23:49:36
In reply to Brintellix question, posted by g_g_g_unit on April 26, 2016, at 0:43:12
Hi there yourself. I've taken Brintellix for nine months after taking Lexapro for over a year, and I did and do feel an improvement of cognition and less anhedonia. For me, I'm hoping the anhedonia as the last lingering symptom of super long etc depression, and I'm optimistic that will lift over time.
10 mg wasn't too much help, but 20 mg does it.
Good luck with whatever you chose. Anhedonia is a bitch.
> Hi there,
>
> Long time no see everyone.
>
> My doctor wants me to try Brintellix and I've been wondering if it's likely to induce anhedonia in the same way that SSRIs do? I know SSRIs work for some, but I always felt very numb, foggy and detached on them -- which made me feel stuck in a limbo and unable to engage with anything. I need to feel some responsiveness to stimuli and my environment. I believe Brintellix improves cognition, which is a plus.
Posted by g_g_g_unit on May 1, 2016, at 3:32:39
In reply to Re: Brintellix question » g_g_g_unit, posted by Horse on April 30, 2016, at 23:49:36
Thanks for the positive input. The thing is, life is pretty sucky when I'm depressed, but I'm still lucky enough to experience *some* mood reactivity, i.e. I can listen to some music or watch TV or call a friend and feel temporarily okay.
On SSRIs, I'm stripped of that -- plus most of my cognitive abilities (I seem to have more clarity when depressed). Add restless legs and sometimes akathisia to the mix and you can see why I avoid them now.
However, I am feeling pretty suicidal, so suspect I'll give it a shot.
> Hi there yourself. I've taken Brintellix for nine months after taking Lexapro for over a year, and I did and do feel an improvement of cognition and less anhedonia. For me, I'm hoping the anhedonia as the last lingering symptom of super long etc depression, and I'm optimistic that will lift over time.
>
> 10 mg wasn't too much help, but 20 mg does it.
>
> Good luck with whatever you chose. Anhedonia is a bitch.
>
Posted by Ruuudy on May 2, 2016, at 23:15:30
In reply to Re: Brintellix question » jonhed, posted by Phillipa on April 26, 2016, at 17:48:07
Hello,
I've been reading & following Dr-Bob.org for years, and have found this site to have the most polite & intellectual people posting comments than any other mental health forum/BB out in the Wild World Wide Web! Of course it was started by Dr. Bob, and I really wish that he still monitored & maintained the site; it's appearing to possibly be overrun with trollers & spammers - I certainly hope this can be controlled because I have learned so much from this site!Thanks!
Rudy
> Hi no Scott is not a doctor. This is a forum of people such as you and I. Scott and some others seem to have a greater understanding and knowledge of meds that most . No doctor is one here to read and prescribe meds. Just sharing of different responses to meds. You can babblemail me also. Phillipa
Posted by J Kelly on May 3, 2016, at 7:26:25
In reply to Re: Brintellix question, posted by Ruuudy on May 2, 2016, at 23:15:30
> Hello,
> I've been reading & following Dr-Bob.org for years, and have found this site to have the most polite & intellectual people posting comments than any other mental health forum/BB out in the Wild World Wide Web! Of course it was started by Dr. Bob, and I really wish that he still monitored & maintained the site; it's appearing to possibly be overrun with trollers & spammers - I certainly hope this can be controlled because I have learned so much from this site!
>
> Thanks!
> RudyHi Rudy :)
I come and go on this site but it always really helps me when I'm trialing new meds or just feeling down.
"most polite & intellectual people posting" so true!!
I hope you'll stick around and continue posting!
Jade
Posted by Phillipa on May 3, 2016, at 10:15:51
In reply to Re: Brintellix question » Ruuudy, posted by J Kelly on May 3, 2016, at 7:26:25
In my nursing news letter articles says that brintellix is going to have a new name beginning I think with a tri. Reason being another med different action completlely is being confused with this one. So if see a new name that is why. Also it's going to still be used as this name brintellix til the supplies run out. Phillipa
Posted by Phillipa on May 3, 2016, at 10:18:15
In reply to Re: Brintellix New Name of Med, posted by Phillipa on May 3, 2016, at 10:15:51
http://www.takeda.com/news/2016/20160503_7397.html
New name change and reason for change Phillipa
Posted by Horse on May 3, 2016, at 15:48:50
In reply to Re: Brintellix New Name of Med, posted by Phillipa on May 3, 2016, at 10:18:15
Good to know! Too bad I like Brintellix because I felt brilliant. Hahaha. Trintellix reminds me of trillion, like Brintellix multiplied :)
Posted by phidippus on May 6, 2016, at 6:27:24
In reply to Re: Brintellix question » g_g_g_unit, posted by SLS on April 26, 2016, at 6:32:34
I never felt blunted on Brintellix, nor does my girlfriend who is currently on it.
Eric
Posted by g_g_g_unit on May 13, 2016, at 3:08:32
In reply to Re: Brintellix question » SLS, posted by phidippus on May 6, 2016, at 6:27:24
> I never felt blunted on Brintellix, nor does my girlfriend who is currently on it.
>
> EricI'm going to start it next week. Did the nausea never subside for you, Eric?
Posted by phidippus on May 13, 2016, at 12:52:36
In reply to Re: Brintellix question » phidippus, posted by g_g_g_unit on May 13, 2016, at 3:08:32
The nausea did subside.
Eric
Posted by babbler20 on May 22, 2016, at 21:56:58
In reply to Re: Brintellix question, posted by Ruuudy on May 2, 2016, at 23:15:30
antidepressant's are no better than placebo
Posted by Horse on May 23, 2016, at 1:53:20
In reply to Re: Brintellix question, posted by babbler20 on May 22, 2016, at 21:56:58
> antidepressant's are no better than placebo
>
> https://www.youtube.com/watch?v=Zihdr36WVi4Not for me. Night and day. I don't need to watch that to know.
Posted by phidippus on May 23, 2016, at 8:38:11
In reply to Re: Brintellix question, posted by babbler20 on May 22, 2016, at 21:56:58
But as Kirsh said, antidepressants do work for severe cases.
Eric
Posted by J Kelly on May 26, 2016, at 5:19:20
In reply to Re: Brintellix question, posted by babbler20 on May 22, 2016, at 21:56:58
> antidepressant's are no better than placebo
>
> https://www.youtube.com/watch?v=Zihdr36WVi4Mine is.
Posted by Ruuudy on May 30, 2016, at 12:40:46
In reply to Re: Brintellix question » babbler20, posted by Horse on May 23, 2016, at 1:53:20
Interesting segment.
Something to ponder over.
I'm what you consider "mildly depressed" - I'd call it dysthymic disorder with superimposed occasional MDD, and very thankfully, it's been nearly 10 years since my last MDD episode.I'm a Prozac (fluoxetine) veteran - started on it in 1990 - 26 years - less a short holiday to participate in a double-blind Paxil study in the mid-90's.
Could it be that the Prozac lifted me out of the MDD episode, and that my continued use of Prozac is simply from the placebo effect? I'm doubtful! But I guess the way to rule that out would be to discontinue the medication - and do I really want to take that risk?
I'm really hoping for the new age antidepressants that you take and get more instantaneous benefits - much like taking a clonazepam as needed.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.