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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 19 of 19. This is the beginning of the thread.
Posted by Jeroen on December 26, 2013, at 6:19:11
minocycline, what side effects i need to watch out for
I HOPE THIS MED will help me for a while : S
Posted by SLS on December 26, 2013, at 7:26:48
In reply to minocycline, what side effects i need to watch out, posted by Jeroen on December 26, 2013, at 6:19:11
> minocycline, what side effects i need to watch out for
>
> I HOPE THIS MED will help me for a while : S1. Pseudotumor cerebri - brain swelling.
2. Reduced sex-drive.#1 is not frequent, but should be monitored for. Ask your doctor about it and learn the symptoms.
http://www.mayoclinic.com/health/pseudotumor-cerebri/DS00851/DSECTION=symptoms
#2 is quite common, unfortunately.
Good luck. Minocycline can do things in the brain that no other single agent can. I wouldn't know how it works in treating schizoid disorders, but modulating glutamate activity might be contributory. My depression improved within a week of starting minocyline. I take 200 mg/day. You might feel overstimulated during the first few days.
- Scott
Posted by Phillipa on December 26, 2013, at 9:24:51
In reply to Re: minocycline, what side effects i need to watch out » Jeroen, posted by SLS on December 26, 2013, at 7:26:48
I was dizzy but the doc just said stop taking it. What happened to doxycycline? Just that it doesn't cross the brain barrier? If not why is it first line treatment for lymes disease? Phillipa
Posted by Jeroen on December 26, 2013, at 10:05:50
In reply to Re: minocycline, what side effects i need to watch out, posted by Phillipa on December 26, 2013, at 9:24:51
;D
Posted by Jeroen on December 27, 2013, at 0:38:24
In reply to Re: minocycline, what side effects i need to watch out » Jeroen, posted by SLS on December 26, 2013, at 7:26:48
what if i get a headache?
Posted by SLS on December 27, 2013, at 8:23:13
In reply to to SLS, posted by Jeroen on December 27, 2013, at 0:38:24
> what if i get a headache?
How often do you get headaches now?
The headache associated with pseudotumor cerebri ususally begins behind the eyes and radiates.
- Scott
Posted by Jeroen on December 27, 2013, at 8:25:34
In reply to Re: to SLS » Jeroen, posted by SLS on December 27, 2013, at 8:23:13
once a month, should i be conserned if i get a normal headache from minocycline not behind the eyes : S
Posted by SLS on December 27, 2013, at 11:42:24
In reply to once a month, posted by Jeroen on December 27, 2013, at 8:25:34
Hi Jeroen.
I would be concerned if you experience a headache that is much more intense than your usual headaches, or an increase in their frequency. I would be cautious, but not afraid of trying minocycline.
- Scott
Posted by Jeroen on December 27, 2013, at 13:47:18
In reply to Re: once a month » Jeroen, posted by SLS on December 27, 2013, at 11:42:24
thanks Scott
Posted by SLS on December 27, 2013, at 15:02:41
In reply to Re: once a month, posted by Jeroen on December 27, 2013, at 13:47:18
> thanks Scott
You know that minocycline acts to reduce overactive glutamate activity, right? In my mind, that should, theoretically, help to lessen positive symptoms. I am probably wrong, though. It turns out that if you give minocycline early in the course of the illness, it helps predominantly with negative symptoms.
You can think of it as a much more potent antiglutamate agent than glycine. However, minocycline has some pretty potent antidepressant effects as well. And if that weren't enough, it is neuroprotective and perhaps even supports neurogenesis. (Neurogenesis has been proven in rats, but this does not translate well to primates like you and me). Minocycline even acts to reduce brain inflammation, for whatever therapeutic benefit this property offers. I am not convinced that inflammation causes depression, but might be the result of psychosocial stress and eventually, the stresses that accompany depression. It is therefore a biomarker of stress, but not necessarily depression. With depression, I think it might be a self-reinforcing cycle in which inflammation and depression feed off of one another.
http://www.dr-bob.org/babble/20120803/msgs/1023257.html
Do you have any other questions about minocycline?
It is crucial to think of minocycline as a drug with many actions, only one of which is antibiotic. It is not an antibiotic drug. It is a drug with antibiotic properties. It is also a drug with antidepressant properties, and perhaps antipsychotic properties.
Minocycline might turn out to be like aspirin for the brain. It does so many things, and they are discovering more about it all the time.
Minocycline + Abilify might make for a particularly effective combination via inhibition of microglial activity.
http://www.ncbi.nlm.nih.gov/pubmed/24100191
Like I said, it would be a mistake to think of minocycline as an antibiotic when it comes to treating mental illness. Of course, its antibiotic activity can help with Lyme Disease.
The first few days of minocycline therapy might make you feel overstimulated. Stick with it. It will likely dissipate.
- Scott
Posted by Jeroen on December 27, 2013, at 15:19:57
In reply to Re: once a month » Jeroen, posted by SLS on December 27, 2013, at 15:02:41
what is overstimulated?
Posted by SLS on December 27, 2013, at 15:30:56
In reply to Re: once a month SLS, posted by Jeroen on December 27, 2013, at 15:19:57
> what is overstimulated?
I meant that minocycline can produce a somewhat uncomfortable amount of excess energy - sort of like a mild Ritalin. I did not experience this. I know someone who did feel a bit overstimulated in the first week. If I recall properly, this lasted for only 2 days.
I am by no means an expert on minocycline, but it seems safe enough to me to be worth taking.
- Scott
Posted by Jeroen on December 27, 2013, at 15:41:40
In reply to Re: once a month SLS » Jeroen, posted by SLS on December 27, 2013, at 15:30:56
ok thanks buddy ill give it a trial and keep you updated
Posted by mogger on December 29, 2013, at 0:13:10
In reply to Re: once a month » Jeroen, posted by SLS on December 27, 2013, at 15:02:41
Why isn't minocycline being used for OCD as glutamate seems to be part of the problem with OCD? I will ask my doctor about it. I have no idea how it is helping but I am on day 6 of N-Acetylglucosamine and it's anti anxiety and positive mood properties are something to be noted. I think it is it's anti inflammatory properties that must be doing something. I have OCD and it is helping. I am keeping my fingers crossed it continues.
Posted by Jeroen on December 29, 2013, at 3:39:31
In reply to Re: once a month, posted by mogger on December 29, 2013, at 0:13:10
nice to hear something is helping
Posted by Jeroen on December 30, 2013, at 0:34:43
In reply to to SLS, posted by Jeroen on December 27, 2013, at 15:41:40
what if i get an headache on minocycline, should i stop immmediatelly? just saying....
Posted by SLS on December 30, 2013, at 7:00:01
In reply to TO SLS URGENT, posted by Jeroen on December 30, 2013, at 0:34:43
> what if i get an headache on minocycline, should i stop immmediatelly? just saying....
I don't know how to answer that question. Certainly, if you experience an intense headache beginning behind the eyes and radiating outward, you should discontinue the minocycline. I would report any headaches to your doctors.
What dosage of minocycline are you planning to take?
- Scott
Posted by Jeroen on December 30, 2013, at 7:21:17
In reply to Re: TO SLS URGENT » Jeroen, posted by SLS on December 30, 2013, at 7:00:01
50 mg of minocycline twice daily
Posted by SLS on December 30, 2013, at 7:37:47
In reply to 50 mg of minocycline twice daily, posted by Jeroen on December 30, 2013, at 7:21:17
> 50 mg of minocycline twice daily
That's where I started, too. I increased my dosage to 200 mg/day after a few weeks. Most of the investigations used 200 mg/day.
http://clinicaltrials.gov/show/NCT01561742
- Scott
This is the end of the thread.
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