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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by Hugh on March 1, 2012, at 11:40:55
In almost every one of the 121 depressed patients studied by Leuchters team, there was a significantly increased synchronicity of rhythmic oscillations. That is, the same frequencies of rhythmic oscillations were emanating from different areas in the brain simultaneously, indicating that these brain structures were linked and working together like meshed gears.
Leuchters team found that these patterns of hyperconnectivity were startlingly prevalent among their depressed patients, compared with the nondepressed patients they used as a control group.
This study was done at UCLA. The whole article is at http://www.thedailybeast.com/articles/2012/02/21/depression-is-linked-to-hyper-connectivity-of-brain-regions-a-new-study-shows0.html
Posted by Phillipa on March 1, 2012, at 12:03:43
In reply to Depression Is Linked to Hyperconnectivity, posted by Hugh on March 1, 2012, at 11:40:55
Want to follow? Phillipa
Posted by SLS on March 1, 2012, at 13:06:24
In reply to Depression Is Linked to Hyperconnectivity, posted by Hugh on March 1, 2012, at 11:40:55
Hi.
Thanks for posting the study.
> This study was done at UCLA. The whole article is at
I am interested in the occurrence of neural hyperactivity and hyperconnectivity as being present in depression. I am now resonding to the addition of a drug called prazosin (Minipress). I am currently investigating the possibility that prazosin might "quiet" these areas of hyperactivity and restore a balance between circuits.
If you happen to come across anything that is relevant to my idea, please post it.
Thank you.
- Scott
Posted by Hugh on March 1, 2012, at 14:24:36
In reply to Re: Depression Is Linked to Hyperconnectivity » Hugh, posted by SLS on March 1, 2012, at 13:06:24
>I am currently investigating the possibility that prazosin might "quiet" these areas of hyperactivity and restore a balance between circuits.
>
> If you happen to come across anything that is relevant to my idea, please post it.
>
> Thank you.
>
> - ScottScott,
I've been thinking of trying prazosin since I've read that it's neuroprotective.
I haven't been able to find anything about the influence of antidepressants or any other drugs on hyperconnectivity, but some neurofeedback clinicians have been targeting hyperconnectivity and in some cases hypoconnectivity. In neurofeedback they usually call it connectivity training or coherence training. Robert Coben is a neurofeedback clinician on Long Island who specializes in treating hyperconnectivity. This is his site:
http://thebrainlabs.com/index.shtml
Nicholas Dogris has developed a brain stimulation system that can target abnormal coherences. It's called NeuroField and the site is http://www.neurofield.org/
This video shows the effect NeuroField has on a brain: http://www.youtube.com/watch?v=69LBGhhj5IE
Posted by linkadge on March 1, 2012, at 17:07:53
In reply to Re: Depression Is Linked to Hyperconnectivity » Hugh, posted by SLS on March 1, 2012, at 13:06:24
Very interesting.
The effective medications probably 'disrupt' some of the oversychronization between brain regions.
The only meds that worked for me were the ones that 'wonk' me out - probably disrupting some of the circuitry which causes the hyper-reflective state.
Linkadge
Posted by uncouth on March 1, 2012, at 19:14:04
In reply to Re: Depression Is Linked to Hyperconnectivity, posted by linkadge on March 1, 2012, at 17:07:53
this is very interesting, i go to neurofeedback and believe it has helped, we are using z-score training which is actually designed to normalize parts of the brain that are statistically "out of line" compared to a database of normal brains.
i haven't read the linked article yet, but i would advise anyone interested in this stuff to check out the pRoshi brain stimulator. My neurofeedback practitioner started me on it, and i eventually bought a unit from her and use it myself. I used it for an hour a day when I was coming off of a PEA addiction, and it really helped. It's a light stimulator you wear like glasses, but the pattern it uses is a pseudorandom (actually very "chaotic") pattern that the brain can't "follow"...the theory is that the brain settles into a deeply meditative state where it self repairs...the "stuck" areas are decohered. which might be a long the lines of this study.
in any event, it may be working for me, but it's not a quick fix. i now use it a few times a week for 20-30 minutes. its expensive though, $1800, but maybe if you use it every day for a year, it will work on your brain. some people have reported amazing results in traumatic brain injury, which is the application it was originally developed for.
Posted by Hugh on March 2, 2012, at 9:33:25
In reply to Re: Depression Is Linked to Hyperconnectivity, posted by uncouth on March 1, 2012, at 19:14:04
I used a pRoshi five years ago. I had a lot of brain fog at the time, and the pRoshi made my head a lot clearer. I also did neurofeedback, which was helpful. I hope to do some more neurofeedback, because there have been so many advances in the field since I did it. Z-score, NeuroField, and LENS are supposed to help break up hypercoherence. A recent innovation in neurofeedback that I'm very interested in trying is Infra-Low Frequency (ILF) training. It's described here:
Posted by alchemy on March 2, 2012, at 11:35:51
In reply to Re: Depression Is Linked to Hyperconnectivity » Hugh, posted by SLS on March 1, 2012, at 13:06:24
Interesting. I don't know if it's related, but I feel like I am also "hyper-aware" of what's going on around me, etc.
I want to just be la-de-da.
This is the end of the thread.
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