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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by poser938 on June 16, 2011, at 14:41:06
so i've been taking risperdal in hopes it would help with mirapex induced anhedonia. i've been taking risperdal a little over a month now and just went from 1mg a day to 2mgs twice a day a few days ago. but so far i dont think ive felt much at all. it definitely hasnt suppressed my emotions any, but it MIGHT have made me a tiny bit more energetic. i'm not sure though. i might need a decently high dose to suppress dopamine activity better so my receptors can upregulate and become more sensitive to dopamine again. if not, i may need a different antipsychotic. maybe a typical antipsychotic.
*shrugs*
Posted by Christ_empowered on June 16, 2011, at 14:57:50
In reply to antipsychotic update!!!, posted by poser938 on June 16, 2011, at 14:41:06
hey. I'm glad to hear you're feeling at least a bit better. That's good news. Risperdal is kind of strange. You get the dose high enough, you may as well be on Haldol--EPS, akathisia, dysphoria, so on and so forth. I have read that really low doses help depression and sometimes kick start mania, though.
Anyway, I'm happy for you. I'd personally advise you not to go too high; the TD and EPS risks are very real, there's weight gain, and there's also dysphoria to deal with. I was dysphoric and twitchy on 4mgs/day, personally.
Has your doctor discussed any other strategies to get you to where you want/need to be? I must admit I find it a bit strange to treat anhedonia with neuroleptics; these drugs are notorious for causing anhedonia, even the newer ones.
That said, do what you need to do to get your brain to where it needs to be so you can live your life. Please keep us all posted.
Posted by poser938 on June 16, 2011, at 15:41:45
In reply to Re: antipsychotic update!!!, posted by Christ_empowered on June 16, 2011, at 14:57:50
haha yes i know it sounds pretty weird to treat anhedonia with risperdal. i was feeling okay until i took the mirapex november 2009. it helped with libido that had been decreased with effexor at 1st until after a month it reversed on me and made me feel horrrrrible! and my brain hasnt gone back to normal since i stopped the mirapex. so im hoping to reverse what the mirapex did by using an antipsychotic.. but im thinking i dont feel the suppressed emotions theses meds cause because me emotions are already suppressed from mirapex making my brain not so sensitive to the effects of dopamine.. i guess i just need to make my receptors work again by blocking them off for a bit. im hoping this idea isnt too cr5azy, but iguess its all me and my doctor can come up with right now...
Posted by Christ_empowered on June 16, 2011, at 16:35:16
In reply to Re: antipsychotic update!!!, posted by poser938 on June 16, 2011, at 15:41:45
do you think supplements might help? I don't know that much about brain chemistry or whatever, but supplements (possibly in addition to your tranquilizer) might be able to help speed up the process of getting you back to baseline. A poster here a while ago was on supplements to help with tardive psychosis (from tranquilizers) and it seemed to be helping, as I recall.
Then again, I'm a vitamin fiend, so do take what I say with a grain of salt.
Posted by SLS on June 16, 2011, at 16:46:02
In reply to Re: antipsychotic update!!!, posted by poser938 on June 16, 2011, at 15:41:45
> haha yes i know it sounds pretty weird to treat anhedonia with risperdal.
What about taking into consideration 5-HT2a antagonism?
- Scott
Posted by floatingbridge on June 16, 2011, at 19:12:25
In reply to antipsychotic update!!!, posted by poser938 on June 16, 2011, at 14:41:06
> it definitely hasnt suppressed my emotions any, but it MIGHT have made me a tiny bit more energetic. i'm not sure though.
I think this sounds good, poser.
i might need a decently high dose to suppress dopamine activity better so my receptors can upregulate and become
more sensitive to dopamine again. if not, i may need a different antipsychotic. maybe a typical antipsychotic.You and others know more about this. I'm glad to hear that maybe you are
feeling a little better. I'm hoping that's progress.
> *shrugs**hugs*
:-)
fb
Posted by sigismund on June 17, 2011, at 20:58:54
In reply to Re: antipsychotic update!!! » poser938, posted by SLS on June 16, 2011, at 16:46:02
>What about taking into consideration 5-HT2a antagonism?
Hi Scott, why would you do that?
Is that low dose Prozac?
Posted by SLS on June 18, 2011, at 4:47:08
In reply to Re: antipsychotic update!!! » SLS, posted by sigismund on June 17, 2011, at 20:58:54
> >What about taking into consideration 5-HT2a antagonism?
>
> Hi Scott, why would you do that?
>
> Is that low dose Prozac?When the population of 5-HT2a receptors in the prefrontal cortex (PFC) is inhibited from firing, it effectively releases the brakes on dopamine (DA) and norepinephrine (NE) activity there. The atypical antipsychotics are potent 5-HT2a antagonists and are generally capable of treating the negative symptoms (deficit syndrome) of schizophrenia. Several antidepressants also antagonize the 5-HT2a receptor. Nortriptyline is one that comes to mind.
Prozac antagonizes 5-HT2c receptors. Interestingly, Prozac is the only AD that I am aware of that increases the release of DA and NE acutely in the PFC.
- Scott
Posted by floatingbridge on June 19, 2011, at 13:57:03
In reply to Re: antipsychotic update!!! » sigismund, posted by SLS on June 18, 2011, at 4:47:08
Scott, this is interesting. Didn't poser run into trouble on prozac (along with miraprex)? I may be confusing him with another poster with post prozac anohedonia.
Posted by poser938 on June 19, 2011, at 17:15:17
In reply to Re: antipsychotic update!!! » poser938, posted by SLS on June 16, 2011, at 16:46:02
why yes i did used to take cyproheptadine which helped me lots with adderall induced anhedonia. im in the same position now because of the mirapex. but i was taking the cyproheptadine for like 6 months but unfortunately my dose got too high on it because i kept developing tolerance. it did help lots but ive been off it for a few months and my tolerance still hasnt gone away.. i am about to start taking it again at an even higher dose... i just need something that really helps, and cyproheptadine can work wonders. it just completely got rid of my adderall induced anhedonia in the past after about a month.
you had a good idea about the 5-ht2a antagonism though.
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