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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by viper1431 on April 28, 2011, at 1:38:43
Hi, just wondering in the case of moclobemide the wiki article states "A single 300 mg dose of moclobemide inhibits 80% of monoamine oxidase A (MAO-A) and 30% of monoamine oxidase B (MAO-B),"
I was wondering if anyone knows what this would be in the case of nardil, ie X dosage of nardil inhibits xx % of MAO ..
cheers/
Posted by SLS on April 28, 2011, at 5:35:47
In reply to nardil dose v MAO inhibition, posted by viper1431 on April 28, 2011, at 1:38:43
> Hi, just wondering in the case of moclobemide the wiki article states "A single 300 mg dose of moclobemide inhibits 80% of monoamine oxidase A (MAO-A) and 30% of monoamine oxidase B (MAO-B),"
Moclobemide actually binds quite loosely at first and then more tightly later on. It is suggested that there is a metabolite of moclobemide that is responsible for the relatively higher affinity for the MAO-A enzyme.
> I was wondering if anyone knows what this would be in the case of nardil, ie X dosage of nardil inhibits xx % of MAO ..
> cheers/I can't comment on Nardil, but Parnate 60 mg yielded almost total MAO blockade for me. Maybe Nardil would be closer to 75 mg. Some people swear by calculating the effective dosage of Nardil by using 1 mg/kg body weight. I am a good example of this. I weigh (a disgusting) 200 lbs (90 kg), which equates 90 mg of Nardil.
- Scott
Posted by wilyee on April 28, 2011, at 8:26:53
In reply to nardil dose v MAO inhibition, posted by viper1431 on April 28, 2011, at 1:38:43
Be honest dont know what the hell it means when maoi inhibition is mentioned,but i will say ur on the better med,molcmide is a sorry excuse for a antidepressant in my book.
Stay on the good one nardil,good luck.
Posted by pedr on April 28, 2011, at 15:23:19
In reply to Re: nardil dose v MAO inhibition » viper1431, posted by SLS on April 28, 2011, at 5:35:47
>>> I weigh (a disgusting) 200 lbs (90 kg), which equates 90 mg of Nardil.
Lol so it's not just me who feels and looks like the World's first pregnant man on 90mg Nardil.
And of course, a large, jutting belly is just what you need when you suffer from social anxiety...
That said, it comes in pretty handy when I'm carrying my 1 yr old son around - it's like a comfy ledge for him to sit on.
Posted by mtdewcmu on April 29, 2011, at 16:48:49
In reply to Re: nardil dose v MAO inhibition » viper1431, posted by SLS on April 28, 2011, at 5:35:47
> I can't comment on Nardil, but Parnate 60 mg yielded almost total MAO blockade for me. Maybe Nardil would be closer to 75 mg. Some people swear by calculating the effective dosage of Nardil by using 1 mg/kg body weight. I am a good example of this. I weigh (a disgusting) 200 lbs (90 kg), which equates 90 mg of Nardil.
>Looks like you need to practice your self-love and positive affirmations.
I am about 200lbs, for the first time in my life. I gained weight like never before when I started Remeron. It's distributed over 6' 3" though.
Posted by mtdewcmu on April 29, 2011, at 16:52:21
In reply to Re: nardil dose v MAO inhibition » SLS, posted by pedr on April 28, 2011, at 15:23:19
>
> And of course, a large, jutting belly is just what you need when you suffer from social anxiety...
>Around the holidays it could be a distinct advantage if you put on a red suit and say ho ho ho.
Posted by viper1431 on May 5, 2011, at 11:25:32
In reply to Re: nardil dose v MAO inhibition, posted by wilyee on April 28, 2011, at 8:26:53
Well i'm actually still on moclobemide :) I'm considering changing to nardil which i've been on before however i like moclobemide because it kills my apetite and binge eating problem, it doesn't help my depression though... i'm a bit worried now that nardil will cause me to start gaining weight after reading the other replies :(
> Be honest dont know what the hell it means when maoi inhibition is mentioned,but i will say ur on the better med,molcmide is a sorry excuse for a antidepressant in my book.
>
> Stay on the good one nardil,good luck.
This is the end of the thread.
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