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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by psychobot5000 on February 10, 2009, at 23:22:34
So, some researcher or other seems to claim that blocking muscarinic receptors (specifically m4) is possibly helpful for OCD (could this explain why paxil was used preferentially for OCD for a while?). And I know one patient (me), whose OC symptoms partly remit during a dose of benadryl, which is quite an anticholinergic.
Are there other anticholinergic (antimuscarinic, really) drugs out there, that one such as I might use to combat OCD? Preferably something relatively 'clean' in terms of its other effects (i.e. less sedating and antihistaminic than benadryl)? I would be a willing guinea pig to see if any such thing works.
Anticholinergic drugs--which are your favorites?
Thanks for any input,
Psychbot
Posted by psychobot5000 on February 10, 2009, at 23:26:39
In reply to Muscarinic antagonists for OCD?, posted by psychobot5000 on February 10, 2009, at 23:22:34
Posted by SLS on February 11, 2009, at 7:22:58
In reply to Muscarinic antagonists for OCD?, posted by psychobot5000 on February 10, 2009, at 23:22:34
If you are looking for a muscarinic antagonist, you might not have to look any further than clomipramine (Anafranil). It is pretty potent in this regard, plus, well, might be the best OCD medication out there. Perhaps it is the anti-muscarinic effects that make it particularly effective. I don't know about M4.
- Scott
> So, some researcher or other seems to claim that blocking muscarinic receptors (specifically m4) is possibly helpful for OCD (could this explain why paxil was used preferentially for OCD for a while?). And I know one patient (me), whose OC symptoms partly remit during a dose of benadryl, which is quite an anticholinergic.
>
> Are there other anticholinergic (antimuscarinic, really) drugs out there, that one such as I might use to combat OCD? Preferably something relatively 'clean' in terms of its other effects (i.e. less sedating and antihistaminic than benadryl)? I would be a willing guinea pig to see if any such thing works.
>
> Anticholinergic drugs--which are your favorites?
>
> Thanks for any input,
> Psychbot
Posted by SLS on February 11, 2009, at 7:24:34
In reply to Re: Muscarinic antagonists for OCD?, posted by SLS on February 11, 2009, at 7:22:58
Unfortunately, Akineton (biperidon) is gone in the US, but perhaps not elsewhere. It was smoother than Cogentin (benztropine).
- Scott
Posted by psychobot5000 on February 11, 2009, at 16:18:22
In reply to Re: Muscarinic antagonists for OCD?, posted by SLS on February 11, 2009, at 7:22:58
Clomipramine--good thought--awfully messy drug, though--so many S/E from all the other targets it hits... If we are going this direction, I suppose we might add in amitriptyline as well--allegedly more anticholinergic than atropine...
It's too bad anticholinergics always seem to hit other targets...
> If you are looking for a muscarinic antagonist, you might not have to look any further than clomipramine (Anafranil). It is pretty potent in this regard, plus, well, might be the best OCD medication out there. Perhaps it is the anti-muscarinic effects that make it particularly effective. I don't know about M4.
>
>
> - Scott
>
>
> > So, some researcher or other seems to claim that blocking muscarinic receptors (specifically m4) is possibly helpful for OCD (could this explain why paxil was used preferentially for OCD for a while?). And I know one patient (me), whose OC symptoms partly remit during a dose of benadryl, which is quite an anticholinergic.
> >
> > Are there other anticholinergic (antimuscarinic, really) drugs out there, that one such as I might use to combat OCD? Preferably something relatively 'clean' in terms of its other effects (i.e. less sedating and antihistaminic than benadryl)? I would be a willing guinea pig to see if any such thing works.
> >
> > Anticholinergic drugs--which are your favorites?
> >
> > Thanks for any input,
> > Psychbot
>
>
This is the end of the thread.
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