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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by bleauberry on January 28, 2009, at 18:15:43
So MAOIs irreversibly shut down the MAO enzymes for what,10 days, 14 days, something roughly like that? But, why then are multiple daily doses needed, or even daily doses? Why would not a once a week dose do the job?
I can only assume that the MAO inhibition is not the mechanism that gives the antidepressant effect. If it was, then a single dose should last a week. But, people relapse or experience withdrawals within days, sometimes mere hours? Why is that? The MAO enzymes are already shut down for the near future. I don't get it.
In the case of Parnate I know there is some amphetamine-like effect at play. But I have no clue what Nardil or Marplan are doing besides the MAO inhibition. It just seems there is something else these drugs are doing accounting for their effects and that it is not the MAO action doing it.
Any thoughts? Ideas? Theories? Comments?
Posted by mav27 on January 28, 2009, at 18:26:35
In reply to Experts Question....The Mechanics of MAOIs, posted by bleauberry on January 28, 2009, at 18:15:43
I took nardil every second day without a problem, sometimes i went a week without taking it and it didn't lose any effect in that time. Perhaps it depends how fast each person regenerates MAO.
Posted by desolationrower on January 29, 2009, at 0:23:48
In reply to Experts Question....The Mechanics of MAOIs, posted by bleauberry on January 28, 2009, at 18:15:43
this is probably the best basic review of known actions of the maois
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1188458
-d/r
Posted by linkadge on January 29, 2009, at 8:44:28
In reply to Re: Experts Question....The Mechanics of MAOIs, posted by desolationrower on January 29, 2009, at 0:23:48
Even though it takes a while for monoamine oxidase levels to fully regerate, it is still being produced at a constant rate. If you only took the drug once a week, you probably would not be achieving a steady rate of inhibition.
But you are right, there are likely other targets of the medications. Nardil affects the metabolism of gaba with one of its metabolites.
Linkadge
Posted by shasling on January 29, 2009, at 21:39:03
In reply to Experts Question....The Mechanics of MAOIs, posted by bleauberry on January 28, 2009, at 18:15:43
This first post,as well as follwing the links below will give you all the maoi info you could ask for.
Posted by shasling on January 29, 2009, at 21:58:06
In reply to Re: Experts Question....The Mechanics of MAOIs, posted by shasling on January 29, 2009, at 21:39:03
sorry heres the link
Posted by SLS on January 30, 2009, at 5:21:21
In reply to Re: Experts Question/sorry heres link, posted by shasling on January 29, 2009, at 21:58:06
> sorry heres the link
>
> http://www.biopsychiatry.com/mao.htmlYup. Exactly. MAO-A is where it's at.
- Scott
Posted by Cseagraves on February 6, 2009, at 20:00:26
In reply to Re: Experts Question/sorry heres link, posted by SLS on January 30, 2009, at 5:21:21
Would taking my daily regimen of amino acids have any effects (negative or positive) while taking an maoi?
CS
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