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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by SLS on January 19, 2009, at 20:39:40
Do dopamine DA receptor agonists really work?
I mean, really, REALLY work - as in long-term remission.
Does anyone know anyone who knows anyone?
I've never seen it for myself.
- Scott
Posted by Phillipa on January 20, 2009, at 0:44:37
In reply to Do dopamine DA receptor agonists really work?, posted by SLS on January 19, 2009, at 20:39:40
Scott honestly there was a guy who posted here and went on 2.5mg of requip and then a trial of other meds and has been in remission for almost two years. He tried Emsam, had Ect I think. Now think he's on the requip low doses of antipsychotic, and trileptal? Changes his meds a lot. But the requip did work for him. Love Phillipa
Posted by Sigismund on January 20, 2009, at 3:27:44
In reply to Do dopamine DA receptor agonists really work?, posted by SLS on January 19, 2009, at 20:39:40
Perhaps I've not been terribly depressed; at any rate I don't think in terms of remission.
The question for me is whether a particular drug is useful or worse than useless, and on that score Trivastal has been OK with me.
Posted by SLS on January 20, 2009, at 8:28:09
In reply to Re: Do dopamine DA receptor agonists really work? » SLS, posted by Sigismund on January 20, 2009, at 3:27:44
> Perhaps I've not been terribly depressed;
Depressed enough, I imagine.
> at any rate I don't think in terms of remission.
Then I'll think in those terms for the both of us. This is not Pollyanna wishful thinking. Even in my most desperate of days, I always thought in terms of remission. Partial responses were helpful, but far from unacceptable for me. I still could not read, learn, remember, nor go to school or work. I did not get out and socialize. I was barely able to keep my apartment. Partial responses did not make life worth living. They just took away the pain.
> The question for me is whether a particular drug is useful or worse than useless, and on that score Trivastal has been OK with me.
But this is exactly the point I'm trying to make. I have never seen a persistent, robust improvement produced by a DA agonist.
- Scott
Posted by Jeroen on January 20, 2009, at 15:53:54
In reply to Do dopamine DA receptor agonists really work?, posted by SLS on January 19, 2009, at 20:39:40
hi SLS
ive been trough all atypicals except Sertindole
the only thing that cured me temporary for 2 months i was happy it was Seroquel 100 mg that magically cured me
but now im stuck and i dont have long term remission from anything
ive seen people been well with zyprexa for 2 years then it pooped out, but 2 years is long compared to my remission is 2 months
now i have tardive dyskinesia, psychosis permanent i think, and schizophrenia and god what else has overcome to me
i do have a cat who likes me very much and i love her too
Posted by bleauberry on January 20, 2009, at 18:35:39
In reply to Do dopamine DA receptor agonists really work?, posted by SLS on January 19, 2009, at 20:39:40
Hi Scott. I was scouting all the review-ratings boards a few weeks ago and was looking at what actual users said about the dopamine agonists. Most were pramipexole, but there were a couple others. There were hundreds of reports, roughly about 80% bad ones.
Basically, bromocriptine was worthless amongst pretty much everyone.
Pramipexole was skewed heavily toward the bad experience side of things. It seemed to be good for restless leg syndrome in tiny doses. Other than that, there were nurmerous mentions of things like craziness, OCD-like behavior, complete personality changes, rage, broken marriages, and all sorts of bizarre things. It scored very badly overall. These things all resolved within a few days of stopping the DA agonist.
But if you look at case studies and trials on pubmed, agonists do pretty well. I guess clinical versus realworld are different, maybe in the way participants are selected? But even in the clinical settings that showed promise with pramipexole, I think it was something like a 60% relapse rate within a couple months.
Posted by Seroquel on January 20, 2009, at 18:37:40
In reply to Re: Do dopamine DA receptor agonists really work? » Sigismund, posted by SLS on January 20, 2009, at 8:28:09
> But this is exactly the point I'm trying to make. I have never seen a persistent, robust improvement produced by a DA agonist.
>
I don't know the answer to your question, but I sure hope they provide long-term relief!I know for certain many of the "other" agents such a ssri's snri's etc. have failed for me so I guess it's worth a shot...for me anyway.
My longest stint of remission was approximately 8 years via clomipramine / clonazepam.
One may fail terribly with DA agonists and do quite well with lamictal, and perhaps vice versa.
Seems the atypicals are prescribed more off-label these days so maybe more time is needed in order to truly rate their effectiveness?
Regards, Rick
Posted by Elanor Roosevelt on January 28, 2009, at 22:36:12
In reply to Re: Do dopamine DA receptor agonists really work?, posted by Seroquel on January 20, 2009, at 18:37:40
my relation with trivastal was short but sweet (except for the puking and the headaches)
being able to feel pleasure in simple things was lovely and gave me a sense of future that i hadn't had for a while
towards the end the only effect was waking up in the middle of the night and laying awake just enjoying a pleasantness for about and hour
oh now i am sad just thinking about how those middle of the night wakings changed the rest of my 24 hrs
but that stopped
i have been trying to bring up my dopamine levels using amino acids
i need a reward system
Posted by Jeroen on January 29, 2009, at 2:26:02
In reply to Re: Do dopamine DA receptor agonists really work?, posted by Elanor Roosevelt on January 28, 2009, at 22:36:12
try an NMDA antagonist like Memantine for tolerance is special but also Amantadine
Posted by SLS on February 5, 2009, at 2:26:28
In reply to Re: Do dopamine DA receptor agonists really work?, posted by Elanor Roosevelt on January 28, 2009, at 22:36:12
:-)
> i need a reward system
How about a reward for being so persistent!
Go ahead. Treat yourself to some chocolate.
- Scott
This is the end of the thread.
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