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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by SLS on January 19, 2009, at 11:59:19
Do you think 5-HT2a antagonism has anything to do with it?
- Scott
Posted by Phillipa on January 19, 2009, at 12:17:26
In reply to What causes AP weight gain?, posted by SLS on January 19, 2009, at 11:59:19
Seriously not trying to be funny or glib but why do so many say that lots of psych meds cause weight gain? Although I've never gained weight from meds but seems I'm in the minority? Isn't abilify one that causes weight loss? Not that familiar with AP's Phillipa
Posted by SLS on January 19, 2009, at 12:30:08
In reply to What causes AP weight gain?, posted by SLS on January 19, 2009, at 11:59:19
> Do you think 5-HT2a antagonism has anything to do with it?
I see that there is a lot of interest recently in the 5-HT2c receptor for weight gain. It seems to help control circulating levels of leptin (the weight-loss hormone). Blocking this receptor reduces levels of leptin, I guess. AP induced weight gain seems to be a complicated thing to understand. I'm not sure it really is at this point.
Any other ideas?
- Scott
Posted by SLS on January 19, 2009, at 12:35:27
In reply to Re: What causes AP weight gain? » SLS, posted by Phillipa on January 19, 2009, at 12:17:26
> Seriously not trying to be funny or glib but why do so many say that lots of psych meds cause weight gain?
> Although I've never gained weight from meds but seems I'm in the minority?
Some people have a type of 5-HT2c receptor (genetic polymorphism) that protects them from weight gain. You probably have this type.
> Isn't abilify one that causes weight loss?
Apparently, not. That's why I asked the question. I am still retaining weight, and Abilify is the only possible culprit. The other drugs I am taking never affected me that way.
- Scott
Posted by linkadge on January 19, 2009, at 18:16:44
In reply to Re: What causes AP weight gain?, posted by SLS on January 19, 2009, at 12:35:27
I would think that 5-ht2c antagonism is a good guess. After all, many other 5-ht2c antagonists are weight gainers. Drugs that come to mind are remeron, cyproheptadine, doxapin, amitriptyline as well as many of the AP's. To note, typical AP's did generally not cause weight gain nor did they act potently at 5-ht2c.
Linakdge
Posted by bleauberry on January 20, 2009, at 18:46:48
In reply to What causes AP weight gain?, posted by SLS on January 19, 2009, at 11:59:19
Scott, I couldn't begin to remember where I saw it. But there was a very lengthy detailed thing I read a few months ago about APs. It looked into how they impacted about 50 different genes. About half of those genes were either turned on (if they had been off) or turned up in volume, while the other half were turned down in volume or off completely. Some of those genes were identified as the ones being directly related to biochemical control of caloric intake, the genes that make it so easy for some people to get overweight and so hard for others to gain any weight. The APs basically turn up the volume on the weight gain genes. I don't think it has much to do with receptor antagonism. I think it is deeper than that. The paper I read had identified all these genes in minute detail and how different APs influenced them. Zyprexa was obviously the worst.
Posted by linkadge on January 20, 2009, at 22:08:27
In reply to Re: What causes AP weight gain? » SLS, posted by bleauberry on January 20, 2009, at 18:46:48
I understand the AP's also negatively mess with signalling in pancreatic cells.
Linkadge
Posted by desolationrower on January 23, 2009, at 2:17:55
In reply to Re: What causes AP weight gain?, posted by linkadge on January 20, 2009, at 22:08:27
In addition to h5t2c:
d2 antagonism isn't good for weight control; dopamine is involved in overall energy level control & activity level.
most are H1 antagonists, and that also correlates to weight gain, its involved with leptin signaling
peripheral adrenoceptors and glucose transport might be involved too...i think the combination is really what does it, reducing metabolism and increasing appetite at the same time. so theres no feedback control.
-d/r
Posted by SLS on January 23, 2009, at 2:54:49
In reply to Re: What causes AP weight gain?, posted by desolationrower on January 23, 2009, at 2:17:55
> In addition to h5t2c:
> d2 antagonism isn't good for weight control; dopamine is involved in overall energy level control & activity level.
> most are H1 antagonists, and that also correlates to weight gain, its involved with leptin signaling
> peripheral adrenoceptors and glucose transport might be involved too...
>
> i think the combination is really what does it, reducing metabolism and increasing appetite at the same time. so theres no feedback control.
>
> -d/r
Thanks. That helps explain things.
- Scott
Posted by Elanor Roosevelt on January 28, 2009, at 22:27:49
In reply to Re: What causes AP weight gain? » desolationrower, posted by SLS on January 23, 2009, at 2:54:49
i think there are two things happening
the actual weight gain that comes from the meds triggering appetite--and this is the hypothalamus--yes?then the gain that is not related to increased caloric intake and the great difficulty of taking off med-related weight--that must be metabolism related
how about those berries oprah has everyone eating?
Posted by SLS on February 4, 2009, at 17:02:23
In reply to Re: What causes AP weight gain?, posted by Elanor Roosevelt on January 28, 2009, at 22:27:49
> how about those berries oprah has everyone eating?
It is a nefarious scheme to exercise mind control over the masses.
- Scott
This is the end of the thread.
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