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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by VIncent_QC on January 21, 2009, at 7:18:33
Hi Everyone,
Some news from me... ;-)I'm on the Manerix(Moclobemide) since yesterday. 300mg/day for 14 days...It's a temporary solution...After we will see if I will get more well and if we up the dose to 600mg or more.
At the same time, someone else start a thread on this board about the possibilities to obtain a drug from another country in the Canada...Well it's where the word (Temporary) apply in my post...
My Doctor and myself are looking into a way to get some Marplan in Canada, since the Marplan seem to be more good than the newer Nardil, that I already try back in 2007. My PDoc is used to get some not approved drugs to treat psychotics diseases from the States to the Canada, but he also explain to me the whole process...
To be able to obtain a drug that is not approved in the Canada, the pharmaceutical company,who make the drug in the other country, have to be represented in the Canada and have an office in the Canada... The PDoc send the prescription to that compagny in the Canada and they import the drug in the Canada...He applies this method often for a specific drug to treat people with schizophrenia (I don't remember the name of the drug)...but it's a good drug not approved and sale in the Canada...
So we plan to get some Marplan in the Canada like this...but the main problem is that I look on the Internet who own the Marplan patented and the compagny name "Oxford Pharmaceutical Services Inc.) don't seem to have an office in the Canada or the equivalent. Before, Marplan was made by Hoffmann-La Roche, well represented in the Canada...but "Oxford" is acquiring ownership of the NDA (New Drug Application, the application needed to get a new drug approved in the United States by the Food and Drug Administration)...
So I'm not sure if my PDoc will be able to get some Marplan for me...
We talk also about the EMSAM patch...it's very expensive but they sell them in the Canada, but mostly of the Doctors and PDoc are not aware of this, my new PDoc seem to be the only one to know it!!! Strange...anyway, we are looking for the Emsam patch also in Canada...My PDoc have some research to do, find the pharmaceutical company who produce it in the Canada...or at least who import it in the Canada...
Well, that's complicated...Since I answer a little bit to the Parnate and Nardil before, but I encounter too much blood pressure problems (mean that i'm very sensitive to the NE effect of these drugs) for the social phobia, the PDoc think that the only way I will improve will be from a MAOI's and probably an irreversible ones...And the only other option left in that field is the Marplan...Oral selegiline will not be a good solution, since it's more a Type-B of MAO, I will get just the stimulation effect of it...with my gastric by-pass, we don'T know exactly what will be the effect on me, and also the Type-B of MAO seem to not be a good way to treat the social phobia and anxiety problem, it's apply more to the people with depressive illiness with a no anxiety symptom, a lack of energy and motivation...at the same time, I don't have energy and I lack a lot of motivation, so maybe it can be effective just to treat that conditions...
We forget every TCA's tries possibilities, since they all have some potent effects on the NE and they all cause some weight gain as well as more daytime sedation... I don't need to add extra pounds and sleep more at daytime...
So that's it...Manerix at 300mg, in case I will improve a little bit...if not, after 14 days, we will talk about the possibilities to have the Marplan or the EMSAM patch. If it's not possible to get them, at least the Marplan, since the EMSAM patch is a lot expensive and I can't afford it, we will increase the Manerix to a 600mg/day...until we reach the 1200mg...and if it's not helping at this dosage, I will probably give to the Nardil a second try...maybe pushing the Nardil to more than 90mg/day and remain at this dose for more than 2 weeks, even if the orthostatic hypotension is hard to tolerate, will help? Who know... maybe the Manerix will help also...???If I don't give it a try I will never know...
I was not really excited about the Manerix, I know it's not worth a lot here, and for what I read on this board, that's not seem to be a terrible choice...but I keep in minds that it's just a temporary solution...I don't put a lot of pressure on my Manerix try and I don't want to push to hard the dosage also..this time, I go with the PDoc indications and I will follow them...
So i'm in a stand-by mode...we will see what will happen soon ;-)
For now, on the Manerix, 150mg X 2times day, I feel a little bit strange. When I take my first 150mg pill last evening, I feel a strange effect like a "rush" of adrenaline inside my head, like I will have to do something very hard or I Will live something very exciting...that's weird...It seem to be more stimulating than the Parnate...but don't affet my heart beat...maybe it's just a psychological effect...who know!...This morning, I take my 150md pill and I feel nothing at all...Anyway...
Well thanks everyone...and if someone know if "Oxford" compagny is represented in the Canada or have an office or the equivalence...or if someone know how to obtain the Marplan in the Canada, don't be shy and post an answer to my questions ;-)
Bye!
Vincent ;-)
Posted by Larry Hoover on January 21, 2009, at 8:40:47
In reply to Temporary solution...Need Marplan in Canada, posted by VIncent_QC on January 21, 2009, at 7:18:33
Well, Vincent, your doctor and yourself certainly understand how things are meant to work.
Two strategies suggest themselves to me. 1. Go ahead with the SAP application to Hoffmann-La Roche. It may not yet have transferred control of the drug to Oxford. 2. Contact Oxford (they're in New Jersey), and ask them about their legal representation in Canada. They very likely have someone on the ground here, even if their offices aren't easily found on the Internet.
I just checked the Health Canada website, and I found another option! Isocarboxid is listed in Schedule F of the Food and Drug Regulations. That means that any registered pharmacist can import the drug by mail or by courier. Maybe you can ask a pharmacist to help you.
Lar
Posted by Phillipa on January 21, 2009, at 10:44:57
In reply to Re: Temporary solution...Need Marplan in Canada, posted by Larry Hoover on January 21, 2009, at 8:40:47
Vincent wouldn't the EMSAM patch solve the gastric bypass probelems direct delivery to blood stream bypassing the stomach and intestines???? Love Phillipa
Posted by Vincent_QC on January 21, 2009, at 12:59:53
In reply to Re: Temporary solution...Need Marplan in Canada, posted by Larry Hoover on January 21, 2009, at 8:40:47
> Well, Vincent, your doctor and yourself certainly understand how things are meant to work.
>
> Two strategies suggest themselves to me. 1. Go ahead with the SAP application to Hoffmann-La Roche. It may not yet have transferred control of the drug to Oxford. 2. Contact Oxford (they're in New Jersey), and ask them about their legal representation in Canada. They very likely have someone on the ground here, even if their offices aren't easily found on the Internet.
>
> I just checked the Health Canada website, and I found another option! Isocarboxid is listed in Schedule F of the Food and Drug Regulations. That means that any registered pharmacist can import the drug by mail or by courier. Maybe you can ask a pharmacist to help you.
>
> Lar
Hi Lar!
Hummm, you help me so much...thanks!!!I don't understand the whole process...what you mean by the SAP ??? The other question is : Did you know the price of the Marplan or the email to contact them (In the New-Jersey) or the address of the web page on the health Canada website?
I think the solution about asking my pharmacist to help me getting the Marplan is the more easy option...my PDoc can be the actor in the whole process...call the pharmacist and ask him about the possibilities to get the Marplan in Canada...I see the PDoc in 14 days, so if you can just give me the web link of the Health Canada page where they state the Isocarboxid is listed in Schedule F of the Food and Drug Regulations, I will be able to make the things more easy to my PDoc and myself...
Thanks for your help mister!!! -)
Bye!
Vincent ;-)
PS: The Manerix give me the biggest migraine I had since a lot of months as well as vivid dreams...I'm also not very comfortable on it...something is weak with that drug...my eyes burns, I feel more anxious than usual...that's not like the usual irreversible MAOI's (exception of Parnate who make my heart race too much)...I don't think I will stay on it for a long time and I hope the Marplan will be THE good option! ;-)
Posted by Vincent_QC on January 21, 2009, at 15:51:24
In reply to Re: Temporary solution...Need Marplan in Canada, posted by Phillipa on January 21, 2009, at 10:44:57
> Vincent wouldn't the EMSAM patch solve the gastric bypass probelems direct delivery to blood stream bypassing the stomach and intestines???? Love Phillipa
Yeah, but EMSAM is more type-B of MAO...mean more stimulation...so for the anxiety i'm not sure if it can help a lot...Marplan seem to be more effective for anxiety problem...I also learn that Oxford is not the owner of the compagny who produce and sale the Marplan now...it's Validus pharma inc...I find the web link of the Marplan website and I contact them directly...to know all the steps to import the Marplan in the Canada...at least to be able to give it a try...I know it will be probably expensive, since I don't work I will maybe not be able to afford it, and the public insurrance system here in Canada will not pay for an import drug...but I'm ready to stop smooking and take that money to give a try to the Marplan...
The Manerix experience is not very funny for now...All I got from it is migraine since last evening...and more anxiety... I wonder why I always got the worst side-effects of a drug... For all what I read here, it's seem to be innefective and more like a placebo...so I assume the side-effects are suppose to be non-existent...so why I have side-effects? That's another mystery...lol One thing is sure, if I can't get the Marplan, I Will ask to return on the Nardil...at least I never had side-effect on it, except the hypotension orthostatic at 90mg/day...but at 75mg it was perfect. With my exposure therapy for anxious problems, i'm sure being stable on a drug will help to improve more well...
I will try to resume the answer I will get from the Validus compagny...I will hope everything will be fine!!!
Well, thanks for your support Phillipa!!! You're so nice!!!
Have a nice day !
Bye!
VIncent ;-)
Posted by Larry Hoover on January 21, 2009, at 17:27:09
In reply to Re: Temporary solution...Need Marplan in Canada » Larry Hoover, posted by Vincent_QC on January 21, 2009, at 12:59:53
Tu parles l'anglais mieux que je parle français. Le site Web de Santé Canada est en français, aussi bien, mais je ne peux pas le lire très bien.
The Special Access Program is the normal process by which a doctor requests medication that is otherwise not available in Canada, from the manufacturer. The application is sent to Health Canada, and if it is approved, is forwarded to the manufacturer. The manufacturer then decides if they will supply the drug. Your PDoc has been using this system for other drugs, according to your first post. That's why I suggested your doctor just go ahead and apply to Hoffmann-La Roche. The Oxford company owns U.S. rights (apparently), but that may not (yet) apply in Canada, which has its own patent laws. So, this would be my first action.
Information about the Special Access Program: http://www.hc-sc.gc.ca/dhp-mps/acces/drugs-drogues/sapfs_pasfd_2002-eng.phpIf Hoffmann-La Roche denies the request, or Oxford has the rights in Canada, I'd then contact Oxford directy to find out who represents them in Canada.
They're at:
1 US Highway 46 West
Totowa, New Jersey
07512 United States of America
Tel: 973-256-0600
Fax: 973-837-0572
Email: info@oxfordpharm.com
WWW: www.OXFORDPHARM.COM/The Health Canada link about importing personal use medication is:
-near the bottom of the page, it says:
"Drugs for personal use which are listed in the Schedule F to the Food and Drug Regulations are allowed to be imported by mail, by courier, or in person when:you are a resident of a foreign country who is visiting in Canada
you are a practitioner, and the importation is not for treating your patients, or
you are a wholesale druggist, a drug manufacturer, or a registered pharmacist, and
the quantity of the drugs is consistent with personal use. "When I read it the first time, I missed the part in the heading where it says "Drugs for personal use"....that means that a pharmacist (or doctor) can import Schedule F drugs for their own personal use. Sorry about misleading you.
Schedule F:
http://laws.justice.gc.ca/en/F-27/C.R.C.-c.870/index.html
Just click on the word "Drugs", and scroll down and you'll find isocarboxid in the Table.BTW, I have never had an order from overseas siezed by Customs. It should also be said that nothing I've ever ordered has abuse potential.
Lar
Posted by Vincent_QC on January 24, 2009, at 8:46:30
In reply to Re: Temporary solution...Need Marplan in Canada » Vincent_QC, posted by Larry Hoover on January 21, 2009, at 17:27:09
> Tu parles l'anglais mieux que je parle français. Le site Web de Santé Canada est en français, aussi bien, mais je ne peux pas le lire très bien.
>
> The Special Access Program is the normal process by which a doctor requests medication that is otherwise not available in Canada, from the manufacturer. The application is sent to Health Canada, and if it is approved, is forwarded to the manufacturer. The manufacturer then decides if they will supply the drug. Your PDoc has been using this system for other drugs, according to your first post. That's why I suggested your doctor just go ahead and apply to Hoffmann-La Roche. The Oxford company owns U.S. rights (apparently), but that may not (yet) apply in Canada, which has its own patent laws. So, this would be my first action.
> Information about the Special Access Program: http://www.hc-sc.gc.ca/dhp-mps/acces/drugs-drogues/sapfs_pasfd_2002-eng.php
>
> If Hoffmann-La Roche denies the request, or Oxford has the rights in Canada, I'd then contact Oxford directy to find out who represents them in Canada.
> They're at:
> 1 US Highway 46 West
> Totowa, New Jersey
> 07512 United States of America
> Tel: 973-256-0600
> Fax: 973-837-0572
> Email: info@oxfordpharm.com
> WWW: www.OXFORDPHARM.COM/
>
> The Health Canada link about importing personal use medication is:
>
> http://www.hc-sc.gc.ca/dhp-mps/compli-conform/int/export-import/medicinebord-medicamentsext_tc-tm-eng.php#6
>
> -near the bottom of the page, it says:
> "Drugs for personal use which are listed in the Schedule F to the Food and Drug Regulations are allowed to be imported by mail, by courier, or in person when:
>
> you are a resident of a foreign country who is visiting in Canada
> you are a practitioner, and the importation is not for treating your patients, or
> you are a wholesale druggist, a drug manufacturer, or a registered pharmacist, and
> the quantity of the drugs is consistent with personal use. "
>
> When I read it the first time, I missed the part in the heading where it says "Drugs for personal use"....that means that a pharmacist (or doctor) can import Schedule F drugs for their own personal use. Sorry about misleading you.
>
> Schedule F:
> http://laws.justice.gc.ca/en/F-27/C.R.C.-c.870/index.html
> Just click on the word "Drugs", and scroll down and you'll find isocarboxid in the Table.
>
> BTW, I have never had an order from overseas siezed by Customs. It should also be said that nothing I've ever ordered has abuse potential.
>
> LarHi ;-)
Thanks for your informations!!!! Very usefull ;-) I was able to find the webpage and read it before I See your message but you explain all of this more easealy than them...So I have two options...My doctor import the drug by mail in the Canada...or I go to my local drugstore with my prescription and the pharmacist import it for me...I also write directly to the new compagny who own the Marplan...at the begining it was LaRoche, after it was Oxford (lack of publicity and money to promote the product) and now it's Validus...so I ask them if it was still on the Schedule F list of drugs, since the webpage of the CAnadian Border was outdated since a little while...I wait for an answer from them...
Finally, I stop the Manerix because it was not very good for me...increase of anxiety (I never have this before when I begin a new drug, I had to double my valium intake (not very a good sign for me, remember me a lot Effexor-XR or the PRozac at 30mg/day and more)...and also BIG migraines...after 3 days of headache, I just decide to stop it this morning...
I think if the Marplan plan doesn't work , I will return on the Nardil who have no side-effect on me...I mean no sedation or weight gain...except the orthostatic hypotension at a 90mg dose day...I had a partial answer on it, reduction of my benzo intake and anxiety level, but not the social anxiety, and it was not the perfect drug in any sense, I mean I don't improve a lot at 75mg/day, who was the daily dosage I take for the more long time...but I was still able to have a more normal life on it than the life I have now... I think if I look in the past and I try to figure out how I was at the time I try the Nardil, I Was defenitly in a more good mental health shape than now....I don't realise this before or when I was on the Nardil...but now I can say it was more good for me than I was thinking...
So well...that's it...if I have an answer from the Validus compagny, I will keep people here inform of how they can obtain it from another country where it's not avaible...
Another time, thanks for your precious help!!!
Have a nice day!
VIncent ;-)
Posted by myco on January 26, 2009, at 12:15:27
In reply to Re: Temporary solution...Need Marplan in Canada, posted by Vincent_QC on January 24, 2009, at 8:46:30
Hey Vince, How did your search/inquiry into importing Marplan into Canada go? Any idea of pricing/availability/procedure/etc..? American meds are insanely expessive (compared to Canada) to my knowledge. Let me know as Marplan is maoi round 2 for me if Nardil fails.
thnx, a fellow canuck
Posted by Vincent_QC on January 26, 2009, at 14:29:06
In reply to Getting Marplan in Canada (VINCE) » Vincent_QC, posted by myco on January 26, 2009, at 12:15:27
> Hey Vince, How did your search/inquiry into importing Marplan into Canada go? Any idea of pricing/availability/procedure/etc..? American meds are insanely expessive (compared to Canada) to my knowledge. Let me know as Marplan is maoi round 2 for me if Nardil fails.
>
> thnx, a fellow canuck
Hi mister!
Well...i'm still waiting from an answer from the Validus compagny regarding the importation procedure of the Marplan in the Canada...I know it's expensive and I think about others solutions before I meet my Psychiatrist doc next week. For now, the Manerix is already a bad "trip" experience...so i'm left without nothing to help me, just a small dose of Valium who is doing nothing for my anxiety, especially the social anxiety...I just feel in the fog and not in this world...and I hate that feeling...I will maybe post a new thread about Selegiline...since it's the only other MAOI avaible in the Canada...I know the Emsam patch are allowed in the Canada, but that's seem hard to get even if it's approved by health Canada...and it's probably expensive as well and not cover by insurrance...
One thing is sure, If the Marplan importation fail, I will have only 2 choices....try to convince my Psychiatrist to try the oral Selegiline (since I don't know what is the good dosage for depression, I will have to post a new thread...) or return on the Nardil (not my ideal goal but what I can do??? ).
The main problem is that i'm suffering from social phobia with too much co-morbidities like depression, general anxiety, panic disorder with agoraphobia and a BIG lack a lot of any motivation and energy that's make my life not really organisated...We think I have also a little problem of ADD without hyperactivity...I just can't do anything good or finish something...or do something usefull for now and keep focus on something...well it's the way I feel...i'm completly empty of energy...physicaly and mentally...and it's not related to depression so it's why maybe the Selegiline, even if it's only in oral form, will help me more than the others maoi's...
I read that Selegiline is made with 2 molecules, one is similar with the regular amphetamine with no increase blood pressure effect. Maybe I will have more energy on it, maybe not... maybe it will help me to move more and be more motivated...maybe not...maybe It will increase my anxiety...maybe not...that's hard to tell...since I never read anything about the relief of the social anxiety and general anxiety from a stimulant drug or the Selegiline...
The Parnate was also similar to stimulant and I had severals high blood pressure crisis on it...and no energy at all...so I really don't know...
Anyway, I will keep you update of the situation...I hope Validus will answer to my e-mail...if not, I will told my Psychiatrist to do the whole process for me and put me on something else in the wating time...cause sometimes it can be a long process to get some drugs by importation...My Pdoc do it sometimes for some of his patients and he told me it can take more than 1 month before getting the drug...so I have no choice and wait...
For now, take care of you and keep the faith!!! ;-)
Bye!
Vincent ;-)
This is the end of the thread.
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