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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 17 of 17. This is the beginning of the thread.
Posted by frillyknickers on October 14, 2008, at 5:51:22
I'm curious if anyone knows of any medical studies that have been done on the subject. I'm aware that there's a lot of anecdotal evidence but I'm curious if there's anything beyond that
also, for people who have found that adderall tends to work, have any similar drugs also worked? or not worked, for that matter?
Posted by linkadge on October 14, 2008, at 6:31:33
In reply to adderall / amphetamines for depression?, posted by frillyknickers on October 14, 2008, at 5:51:22
They were fairly routinely used for depression in the 50-70's.
Some new research sugests that amphetamines are neurotoxic even in ADHD doeses.
They're going to end up leaving you more depleating in the long run.
Linkadge
Posted by frillyknickers on October 14, 2008, at 7:07:36
In reply to Re: adderall / amphetamines for depression?, posted by linkadge on October 14, 2008, at 6:31:33
could you provide some more references?
Posted by azalea on October 14, 2008, at 9:34:16
In reply to adderall / amphetamines for depression?, posted by frillyknickers on October 14, 2008, at 5:51:22
Here's a research studying using methylphenidate as an augmenting agent for treating depression. Monotherapy with stimulants is generally not used to treat depression. However, adjunctive stimulants are used to treat partial responders and to counteract medication-induced sedation.
J Clin Psychopharmacol. 2006 Dec;26(6):653-6.
A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression.
Patkar AA, Masand PS, Pae CU, Peindl K, Hooper-Wood C, Mannelli P, Ciccone P.
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA. ashwin.patkar@duke.eduWe examined the efficacy and tolerability of augmentation with an extended release formulation of methylphenidate (OROS MPH, Concerta) in patients with major depression who were nonresponders or partial responders to antidepressants. Sixty subjects with treatment-resistant depression (TRD) participated in a 4-week, randomized, double-blind, placebo-controlled study of augmentation with methylphenidate (18-54 mg/d). The preexisting antidepressant dose was unchanged. The primary efficacy measure was change in the 21-item Hamilton Depression Rating Scale from randomization to end of treatment. Data were analyzed with intent-to-treat with last observation carried forward approach. There were no statistically significant differences between the methylphenidate (n = 30) and placebo (n = 30) groups in reduction in 21-item Hamilton Depression Rating Scale scores (drug, -6.9; placebo, -4.7) from baseline to end of treatment (F1,47 = 1.24, P = 0.22), although responders were numerically higher in the extended-release methylphenidate group (40.0%) than in the placebo group (23.3%). On the secondary efficacy measures of changes in Clinical Global Impression-Improvement and Severity scores and Beck Depression Inventory-Second Edition, the drug failed to separate from placebo, although the proportion of responders in the drug group were numerically higher than placebo. There were no significant differences in weight, heart rate, and blood pressure changes between the 2 groups. The common adverse events were loss of appetite, nausea, headache, and anxiety. The mean dose of drug was 34.2 mg/d. The study did not demonstrate a statistically significant benefit for augmentation with methylphenidate in TRD. Combination of methylphenidate with antidepressants was well tolerated. Adequately powered, randomized, controlled trials are necessary to fully evaluate the efficacy of extended-release methylphenidate in TRD.
> I'm curious if anyone knows of any medical studies that have been done on the subject. I'm aware that there's a lot of anecdotal evidence but I'm curious if there's anything beyond that
>
> also, for people who have found that adderall tends to work, have any similar drugs also worked? or not worked, for that matter?
Posted by rjlockhart04-08 on October 14, 2008, at 10:43:29
In reply to methylphenidate augmentation » frillyknickers, posted by azalea on October 14, 2008, at 9:34:16
I've looked up Dexedrine and about what causes the horrid mood around 5pm? its a "drop off"
But anyways, yes, i read how d/lamphetamine is used
1.ADHD
2.Narcolpsy
3.Other purposes- (that includes invdividuels resistant to antidepressnat treatment, or used with an antidepressant for therpy for depression)Adderall only lasts 4 hours, i admit it will get you into a good mood because of its rapid "onset", faster than dexedrine because of it's L isomer (levoamphetmine) which causes more of a "kick". When it wears off, its not really good for depression at all, it could make worse after the "drop off". So you will have to discuss, the dosing scheduel with your doctor.
10 year of taking Adderall, i kinda...know how it works.
Dexedrine was better, it has no "kick", like Adderall.
rj
Posted by linkadge on October 14, 2008, at 14:02:25
In reply to what research?, posted by frillyknickers on October 14, 2008, at 7:07:36
http://jpet.aspetjournals.org/cgi/content/short/315/1/91
Linkadge
Posted by greywolf on October 14, 2008, at 19:13:42
In reply to Re: adderall / amphetamines for depression?, posted by linkadge on October 14, 2008, at 6:31:33
> They were fairly routinely used for depression in the 50-70's.
>
> Some new research sugests that amphetamines are neurotoxic even in ADHD doeses.
>
> They're going to end up leaving you more depleating in the long run.
>
>
> Linkadge
>Linkadge, I have to say, again, reading your posts is a real pleasure. Sometimes it seems like I learn more from you than from some docs I've had in the past.
Greywolf
Posted by linkadge on October 14, 2008, at 20:14:53
In reply to Re: adderall / amphetamines for depression? » linkadge, posted by greywolf on October 14, 2008, at 19:13:42
I don't know what I said.
>Sometimes it seems like I learn more from you >than from some docs I've had in the past.
Sure that isn't the painkillers talking :) ?
Linkadge
Posted by greywolf on October 14, 2008, at 20:39:51
In reply to Re: adderall / amphetamines for depression? » greywolf, posted by linkadge on October 14, 2008, at 20:14:53
> I don't know what I said.
>
> >Sometimes it seems like I learn more from you >than from some docs I've had in the past.
>
> Sure that isn't the painkillers talking :) ?
>
> Linkadge
>
>
>
Just making an overall observation concerning your valuable contributions to this board. The fact that I had to type "board" 4 times to get it right doesn't mean anything, of course. ;)Greywolf
Posted by rjlockhart04-08 on October 15, 2008, at 12:39:10
In reply to Re: adderall / amphetamines for depression?, posted by greywolf on October 14, 2008, at 20:39:51
Just go on google and type "dextroamphetamine resistant antidepressant therapy"
Read the first Section of this: it states, it is used with an antidepressant.
Dont believe me, Just type in Vyvanse and depression, it's used for depression sometimes.
rj
Posted by Phillipa on October 15, 2008, at 12:44:31
In reply to Re: adderall / amphetamines for depression? » greywolf, posted by linkadge on October 14, 2008, at 20:14:53
Link are you on pain killers or was it a joke as greywolf had the surgery. And hi greywolf doing good today I hope. Love Phillipa
Posted by Jay_Bravest_Face on October 15, 2008, at 23:18:37
In reply to Re: adderall / amphetamines for depression? » linkadge, posted by greywolf on October 14, 2008, at 19:13:42
First off, dextroamphetamine helped me complete my Masters degree, and it is helping as I go back and complete my Bachelor of Education. This is over a five year period.
Second, SSRIs can and do help many people (like me7 years on Prozac) and most pdocs know about the augmentation strategies with these kind of drugs. Please dont jump to conclusions. Just because *you* havent been helped doesnt mean others cant be.Jay
Posted by greywolf on October 16, 2008, at 8:35:48
In reply to Re: adderall / amphetamines for depre » linkadge, posted by Jay_Bravest_Face on October 15, 2008, at 23:18:37
> First off, dextroamphetamine helped me complete my Masters degree, and it is helping as I go back and complete my Bachelor of Education. This is over a five year period.
> Second, SSRIs can and do help many people (like me7 years on Prozac) and most pdocs know about the augmentation strategies with these kind of drugs. Please dont jump to conclusions. Just because *you* havent been helped doesnt mean others cant be.
>
> Jay
>I don't know why you are responding to me in this fashion. I have no problem with anybody trying anything, regardless of whether it has helped me in the past. I have been on many augmentation strategies and I'm puzzled by your response.
Greywolf
Posted by Jay_Bravest_Face on October 16, 2008, at 16:32:22
In reply to Re: adderall / amphetamines for depre » Jay_Bravest_Face, posted by greywolf on October 16, 2008, at 8:35:48
Posted by Jay_Bravest_Face on October 16, 2008, at 16:39:23
In reply to Re: adderall / amphetamines for depre » Jay_Bravest_Face, posted by greywolf on October 16, 2008, at 8:35:48
Sorry about that Greywolf. It wasn't meant to be to you at all. It was just in Linkadge's post to something you said that caused the mix-up. Please forgive me..I would never mean to wrongfully accuse.
> > First off, dextroamphetamine helped me complete my Masters degree, and it is helping as I go back and complete my Bachelor of Education. This is over a five year period.
> > Second, SSRIs can and do help many people (like me7 years on Prozac) and most pdocs know about the augmentation strategies with these kind of drugs. Please dont jump to conclusions. Just because *you* havent been helped doesnt mean others cant be.
> >
> > Jay
> >
>
> I don't know why you are responding to me in this fashion. I have no problem with anybody trying anything, regardless of whether it has helped me in the past. I have been on many augmentation strategies and I'm puzzled by your response.
>
> Greywolf
Posted by greywolf on October 16, 2008, at 17:31:23
In reply to Oh I see...I resp. to a post about a post..Sorry.. » greywolf, posted by Jay_Bravest_Face on October 16, 2008, at 16:39:23
> Sorry about that Greywolf. It wasn't meant to be to you at all. It was just in Linkadge's post to something you said that caused the mix-up. Please forgive me..I would never mean to wrongfully accuse.
>
>
> > > First off, dextroamphetamine helped me complete my Masters degree, and it is helping as I go back and complete my Bachelor of Education. This is over a five year period.
> > > Second, SSRIs can and do help many people (like me7 years on Prozac) and most pdocs know about the augmentation strategies with these kind of drugs. Please dont jump to conclusions. Just because *you* havent been helped doesnt mean others cant be.
> > >
> > > Jay
> > >
> >
> > I don't know why you are responding to me in this fashion. I have no problem with anybody trying anything, regardless of whether it has helped me in the past. I have been on many augmentation strategies and I'm puzzled by your response.
> >
> > Greywolf
>
>
No problem at all.Take care.
Greywolf
Posted by linkadge on October 17, 2008, at 13:25:43
In reply to Re: adderall / amphetamines for depre » linkadge, posted by Jay_Bravest_Face on October 15, 2008, at 23:18:37
Hey, if you want to ingest neurotoxins don't let me stop you.
And yes, I still fail to believe that amphetamines are provide any form of long term treatment of depression. If the depression is a result of (or compounded by) AD/HD then this may be different.
And, yes I will make all the conclusions I want thank you very much. You don't have to believe them however (and perhaps this board will kick me off again). Either way, I really don't care.
Linkadge
This is the end of the thread.
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