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Dr. Bob is Robert Hsiung, MD,
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Posted by eric wagner on September 30, 2008, at 17:57:05
Has anyone been using Memantine or any other NMDA antagonist in combination w/ a stimulant successfully to combat stimulant tolerance?
Does anyone know of any medical journals available which I can show my Psychiatrist to possibly sway him to try the combo.?
Stimulants have been the only med. which ever gave me any relief, despite tolerance to all its effects in about 2 weeks.
Any info./response will be much appreciated.
Take Care & Be Well,
Eric M. Wagner
Posted by dbc on September 30, 2008, at 18:03:48
In reply to Stimulant + Memantine Experiences, posted by eric wagner on September 30, 2008, at 17:57:05
Magnesium supplementation is often used with amphetamine supplementation (it has nmda antagonist properties). I belive Memantine and Lamictal arent that different in action if you research it. Im currently taking lamictal/magnesium and dexedrine and notice little to no tolerance.
Posted by eric wagner on September 30, 2008, at 18:07:36
In reply to Re: Stimulant + Memantine Experiences, posted by dbc on September 30, 2008, at 18:03:48
> Magnesium supplementation is often used with amphetamine supplementation (it has nmda antagonist properties). I belive Memantine and Lamictal arent that different in action if you research it. Im currently taking lamictal/magnesium and dexedrine and notice little to no tolerance.
how much of each do you take dbc, if you don't mind me asking?
Thnx
Posted by dbc on October 3, 2008, at 15:38:04
In reply to Re: Stimulant + Memantine Experiences, posted by eric wagner on September 30, 2008, at 18:07:36
400mg of magnesium and 200mg of lamictal.
Posted by eric wagner on October 3, 2008, at 16:31:32
In reply to Re: Stimulant + Memantine Experiences, posted by dbc on October 3, 2008, at 15:38:04
> 400mg of magnesium and 200mg of lamictal.
Thnx
Dexedrine?
emw
Posted by dbc on October 3, 2008, at 18:51:05
In reply to Re: Stimulant + Memantine Experiences » dbc, posted by eric wagner on October 3, 2008, at 16:31:32
Yeah, around 30mg a day.
Posted by azalea on October 15, 2008, at 18:15:24
In reply to Stimulant + Memantine Experiences, posted by eric wagner on September 30, 2008, at 17:57:05
Perhaps some evidence from rodents . . .
Neuropharmacology. 2008 Jun;54(8):1254-63. Epub 2008 Apr 9.
Memantine protects against amphetamine derivatives-induced neurotoxic damage in rodents.
Chipana C, Torres I, Camarasa J, Pubill D, Escubedo E.
Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, Avda Joan XXIII s/n, Zona Universitaria Pedralbes, 08028 Barcelona, Spain.We hypothesize that 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH) interact with alpha-7 nicotinic receptors (nAChR). Here we examine whether memantine (MEM), an antagonist of NMDAR and alpha-7 nAChR, prevents MDMA and METH neurotoxicity. MEM prevented both serotonergic injury induced by MDMA in rat and dopaminergic lesion by METH in mice. MEM has a better protective effect in front of MDMA- and METH-induced neurotoxicity than methyllycaconitine (MLA), a specific alpha-7 nAChR antagonist. The double antagonism that MEM exerts on NMDA receptor and on alpha-7 nAChR, probably contributes to its effectiveness. MEM inhibited reactive oxygen species production induced by MDMA or METH in synaptosomes. This effect was not modified by NMDA receptor antagonists, but reversed by alpha-7 nAChR agonist (PNU 282987), demonstrating a preventive effect of MEM as a result of it blocking alpha-7 nAChR. In synaptosomes, MDMA decreased 5-HT uptake by about 40%. This decrease was prevented by MEM and by MLA but enhanced by PNU 282987. A similar pattern was observed when we measured the dopamine transport inhibited by METH. The inhibition of both transporters by amphetamine derivatives seems to be regulated by the calcium incorporation after activation of alpha-7 nAChR. MDMA competitively displaces [(3)H]MLA from rat brain membranes. MEM and METH also displace [(3)H]MLA with non-competitive displacement profiles that fit a two-site model. We conclude that MEM prevents MDMA and METH effects in rodents. MEM may offer neuroprotection against neurotoxicity induced by MDMA and METH by preventing the deleterious effects of these amphetamine derivatives on their respective transporters.
> Has anyone been using Memantine or any other NMDA antagonist in combination w/ a stimulant successfully to combat stimulant tolerance?
>
> Does anyone know of any medical journals available which I can show my Psychiatrist to possibly sway him to try the combo.?
>
> Stimulants have been the only med. which ever gave me any relief, despite tolerance to all its effects in about 2 weeks.
>
> Any info./response will be much appreciated.
>
> Take Care & Be Well,
> Eric M. Wagner
This is the end of the thread.
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