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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by Medline on September 27, 2008, at 3:33:01
As the phenelzine-metabolite phenylethylidenehydrazine is a potent GABA-transaminase inhibitor I thought that augmenting Nardil with a small dose of the GABA-reuptake inhibitor tiagabine (Gabitril) twice daily might make it an even better anxiolytic for Social Anxiety. What do you think?
Posted by SLS on September 27, 2008, at 5:54:50
In reply to Augmenting Nardil with Gabitril?, posted by Medline on September 27, 2008, at 3:33:01
Gabitril is a strange drug. It will either make you feel better or make you feel worse.
Theories are nice, but what clinical evidence is there that this combination would work? The proof is in how well it works in real life. If it is safe, why not give it a try? What about the potential for Gabitril to induce seizures? Does combining this drug with an MAOI further reduce the seizure threshold?
- Scott
Posted by yxibow on September 29, 2008, at 1:15:32
In reply to Re: Augmenting Nardil with Gabitril?, posted by SLS on September 27, 2008, at 5:54:50
> Gabitril is a strange drug. It will either make you feel better or make you feel worse.
>
> Theories are nice, but what clinical evidence is there that this combination would work? The proof is in how well it works in real life. If it is safe, why not give it a try? What about the potential for Gabitril to induce seizures? Does combining this drug with an MAOI further reduce the seizure threshold?
>
>
> - ScottYes, I would agree too, from what I know, Gabitril is one of maybe two or three AEDs I haven't tried because of effects. For reasons contrary to what one would think, some epileptic agents can actually cause seizures for some individuals, and Gabitril is known to do that.
This is the end of the thread.
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