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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by tensor on March 3, 2008, at 1:35:34
Please share your experiences with this med, it is listed as an antidepressant here in Finland but I have never tried it. I'm considering it for cycling MDD with fatigue.
Thanks/Mattias
Posted by bleauberry on March 4, 2008, at 16:52:58
In reply to SULPIRIDE, posted by tensor on March 3, 2008, at 1:35:34
I have not tried sulpride but I have tried the very similar amisulpride. At low doses these block the dopamine autoreceptors (the ones that sense how much dopamine transmission there is). The result is they fire out more dopamine. Theories say more dopamine equals more interest, more motivation, less fatigue, less depression. So if someone has low dopamine, sulpride has good potential since it will stimulate dopamine. At higher doses they begin to block all dopamine receptors. So the dopamine stimulation continues, and yet overexcitation is dampened at the same time. Thus these drugs have shown themselves to be effective for a wide range of symptoms and the doses can be tailored to that.
Since we can't get inside a brain to figure it out, there is no way to know if someone's mood disorder is based primarily in the serotonin system, the norepinephrine system, or the dopamine system. If it is serotonin, sulpride might not be much help. If it is hypodopamine, it could help a ton.
Posted by Jamal Spelling on March 4, 2008, at 17:02:56
In reply to Re: SULPIRIDE, posted by bleauberry on March 4, 2008, at 16:52:58
By "dopamine autoreceptors", do you mean D1 or D2 receptors?
Posted by dopamine123 on March 6, 2008, at 15:37:42
In reply to Re: SULPIRIDE » bleauberry, posted by Jamal Spelling on March 4, 2008, at 17:02:56
I've also tried amisulpride in the past and found it good for motivation and interest. It mostly helps negative schizophrenic symptoms (apathy, alogia, anhedonia, emotional blunting, and avolition). Negative symptoms are also fairly common in people with depression. I would expect sulpride to do the same.
>By "dopamine autoreceptors", do you mean D1 or D2 receptors?
Only D2/D3 receptors are autoreceptors. D1 receptors only exist as postsynaptic receptors. At a low dose, amisulpride/sulpride should only block the d2/d3 autoreceptors that control the synthesis and release of dopamine. Postsynaptic d1/d2/d3/d4/d5 are not blocked and are thus activated to a greater degree.
Posted by tensor on March 6, 2008, at 23:56:52
In reply to Re: SULPIRIDE, posted by dopamine123 on March 6, 2008, at 15:37:42
>Only D2/D3 receptors are autoreceptors.
So how many(currently known) DA recptors are presynaptic and which are autorecptors? I was under the impression that there was only one autoreceptor for negative feedback. Also, what is the relation between e.g. presynaptic DA2 and postsynaptic DA2 given that they share the same name?
Would appreciate a clarification.
/Mattias
Posted by Dopamine123 on March 11, 2008, at 17:33:25
In reply to Re: SULPIRIDE » dopamine123, posted by tensor on March 6, 2008, at 23:56:52
>So how many(currently known) DA recptors are presynaptic and which are autorecptors? I was under the impression that there was only one autoreceptor for negative feedback.
I think "presynaptic" and "autoreceptor" are basically synonyms. From what I have read, I think only D2 and D3 receptors exist as autoreceptors. D1, D4 and D5 exist solely as postsynaptic receptors.
http://www.springerlink.com/content/g6513079543465w5/http://www.nature.com/npp/journal/v23/n5/full/1395548a.html
>"It is known that D2/D3 autoreceptors are enriched in the SN and the VTA and that systemic or local administration of D2/D3 agonists into these structures significantly reduces the firing rate of dopaminergic neurons">"Also, what is the relation between e.g. presynaptic DA2 and postsynaptic DA2 given that they share the same name?"
They share the same structure, and they activate the same intracellular cascade (inside the neuron).
http://www.ncbi.nlm.nih.gov/pubmed/9457173
>"The diverse physiological actions of dopamine are mediated by at least five distinct G protein-coupled receptor subtypes. Two D1-like receptor subtypes (D1 and D5) couple to the G protein Gs and activate adenylyl cyclase."
This is the end of the thread.
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