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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by ben on July 9, 2001, at 14:32:58
Does anyone knows the stimulant Pirisudanol (Nadex) from Novartis (Switzerland) ? Or does anyone having some experiences with it ?
It is used very seldom for states of exhaustion during depression, but why ?
Posted by SalArmy4me on July 9, 2001, at 22:20:31
In reply to Pirisudanol (Nadex) a stimulant -anyone ?, posted by ben on July 9, 2001, at 14:32:58
I searched every medical journal and couldn't find anything on it.
> Does anyone knows the stimulant Pirisudanol (Nadex) from Novartis (Switzerland) ? Or does anyone having some experiences with it ?
> It is used very seldom for states of exhaustion during depression, but why ?
Posted by leendee on December 8, 2004, at 17:28:30
In reply to Re: Pirisudanol (Nadex) a stimulant -anyone ? » ben, posted by SalArmy4me on July 9, 2001, at 22:20:31
I found some information about this drug in Spanish: following is the google translation. it's a little weird and not too informative unfortunatly. ("upheavals of the attention"?)
But apparently it is a type of ADD treatment.
Upheavals of the attention,
concentration and of the memory(dimaleato Pirisudanol)
PROPERTIES: It has a metabolic effect at level of the cells of the nervous system facilitating the processes of activation of the cerebral crust, stimulating the acetilcolina formation.
It has an action on the attention, increase of the memory, recovery of the intellectual faculties, improvement of the psicomotora coordination and ansiolítico effect.
INDICATIONS: Upheavals of the attention, concentration and of the memory.
CONTRAINDICATIONS: Contraindicated in treatment with L-it drugs.
DOSAGE:
Adults: 2-3 capsules to the day, after the meals.
Greater children of 6 years: 1-2 capsules to the day.
Posted by ed_uk on December 9, 2004, at 5:52:33
In reply to Re: Pirisudanol (Nadex) a stimulant -anyone ?, posted by leendee on December 8, 2004, at 17:28:30
Hi,
From www.psychotropics.dk
pirisudanol (pyrisuccideanol)
Description
Psychostimulant. Stimulates the ascending reticulated system and improves the hemodynamic and metabolic conditions of the neuronal function. Light anxiolytic effect. Maximum blood concentration achieved 2 hours after single oral dose. Major metabolite: pyridoxic acid. Concommitant use with levodopa contraindicated. No recent publications.Brand names......... Countries abbreviated eg. ESP=Spain etc.
Mentis................ Menarini, ESP: caps. 300mg
Mentium................. Guidotti, ITA: caps. 300mg
Nadex Forte..................... Zyma, PL, B, Novartis Pharma, CH: tabs. 600mg (deleted in B)
Nadexen................ Zyma, GR: caps. 300mg
Pridana.................. Zyma Farm Portug, PORT: tabs. 600mg - caps. 300mgStivane............ Beaufour, F: caps. 300mg (maleate)
Ed.
Posted by ed_uk on December 9, 2004, at 6:01:38
In reply to Pirisudanol (Nadex) a stimulant -anyone ?, posted by ben on July 9, 2001, at 14:32:58
Posted by ed_uk on December 9, 2004, at 7:47:50
In reply to Re: Pirisudanol (Nadex) a stimulant -anyone ?, posted by ed_uk on December 9, 2004, at 5:52:33
Hi,
More info.....
Pirisudanol is the succinic acid ester of pyridoxine (a form of vitamin B6) and of deanol (DMAE). It has been used in doses of up to 1.2 g daily. Sadly, it hasn't been studied very thoroughly. Pirisudanol has been used to treat mild cognitive impairment (ie. mild dementia). It has also been used as a treatment for fatigue and depression.
Deanol (DMAE or dimethylaminoethanol) is a precursor of choline, it may enhance central acetylcholine formation slightly. It has been used as a central stimulant in the treatment of hyperactivity in children but its efficacy is not proven. It has been included in preparations used as 'tonics' and for the management of impaired mental function.
As far as I know, pirisudanol is no longer available in Belgium, France or Switzerland. It is possibly still used in Italy (Mentium), Portugal (Pridana) and Spain (Mentis). This information on availability may be out of date.
Pirisudanol is probaly hard to get hold of. DMAE, on the other hand, is available as a supplement. I'm sure that some of the people on psycho-babble alternative will have taken it. As is the case with pirisudanol, deanol hasn't been studied very thoroughly. In terms of side effects, I did come across one possible case of tardive dyskinesia in the medical literature.
Regards,
Ed.
Posted by leendee on December 10, 2004, at 13:34:10
In reply to Re: Pirisudanol / pyrisuccideanol, posted by ed_uk on December 9, 2004, at 7:47:50
I have some pirisudanol and I took two capsules yesterday, sorry don't know mgs now, normal, Mentis brand. They did not seem to have any effect. Thanks for your information Ed_uk! although it is just as vague as everything I was able to find! maybe it's just a bad drug that no one cares about b/c its not effective!
Posted by ed_uk on December 10, 2004, at 13:37:20
In reply to Re: Pirisudanol / pyrisuccideanol, posted by leendee on December 10, 2004, at 13:34:10
I know... it hasn't really been researched very much!!
All the best,
Ed.
Posted by Iansf on December 10, 2004, at 16:37:04
In reply to Re: Pirisudanol / pyrisuccideanol, posted by ed_uk on December 9, 2004, at 7:47:50
> Hi,
>
> More info.....
>
> Pirisudanol is the succinic acid ester of pyridoxine (a form of vitamin B6) and of deanol (DMAE). It has been used in doses of up to 1.2 g daily. Sadly, it hasn't been studied very thoroughly. Pirisudanol has been used to treat mild cognitive impairment (ie. mild dementia). It has also been used as a treatment for fatigue and depression.
>
I wonder if just taking pyridoxine and DMAE together would have an effect. I've not seen anyone suggest the combination anywhere, but probably someone has.
Posted by ed_uk on December 11, 2004, at 15:50:42
In reply to Re: Pirisudanol / pyrisuccideanol » ed_uk, posted by Iansf on December 10, 2004, at 16:37:04
Hi,
Perhaps it would, or maybe just taking the DMAE on its own would have a similar effect.
Regards,
Ed.
Posted by raico on September 18, 2007, at 6:33:44
In reply to Re: Pirisudanol / pyrisuccideanol, posted by leendee on December 10, 2004, at 13:34:10
hi
i live in spain and in august 2007 was diagnosed with ADD by a psychologist. My local doctor when i went to see first in May put me on Mentis 2 pills/day for 3 months while i was waiting for the appointment with a psychologist. when the 3 months finished i had to take a months rest, then 3 months again. When i first started taking mentis i noticed an increased mental focus and a slight buzz. throughout the time the effect would come and go and vary a lot. it was great when it worked. I did a lot of research and apparently its only available in a few countries in Europe with switzerland, belgium for example having taken them off shelves. There is very little info on this drug and has hardly been researched. Here in spain apparently its available without prescription. i have yet to confirm this however. My psychologist said he would increase the dose to 3 pills/day for another 3 months but my doctor only prescribed me my old dosage for 1 month. I need to go back and correct the prescription...
Posted by raico on September 18, 2007, at 10:47:39
In reply to Re: Pirisudanol / pyrisuccideanol, posted by ed_uk on December 9, 2004, at 7:47:50
> Hi,
>
> More info.....
>
> Pirisudanol is the succinic acid ester of pyridoxine (a form of vitamin B6) and of deanol (DMAE). It has been used in doses of up to 1.2 g daily. Sadly, it hasn't been studied very thoroughly. Pirisudanol has been used to treat mild cognitive impairment (ie. mild dementia). It has also been used as a treatment for fatigue and depression.
>
> Deanol (DMAE or dimethylaminoethanol) is a precursor of choline, it may enhance central acetylcholine formation slightly. It has been used as a central stimulant in the treatment of hyperactivity in children but its efficacy is not proven. It has been included in preparations used as 'tonics' and for the management of impaired mental function.
>
> As far as I know, pirisudanol is no longer available in Belgium, France or Switzerland. It is possibly still used in Italy (Mentium), Portugal (Pridana) and Spain (Mentis). This information on availability may be out of date.
>
> Pirisudanol is probaly hard to get hold of. DMAE, on the other hand, is available as a supplement. I'm sure that some of the people on psycho-babble alternative will have taken it. As is the case with pirisudanol, deanol hasn't been studied very thoroughly. In terms of side effects, I did come across one possible case of tardive dyskinesia in the medical literature.
>
> Regards,
> Ed.
>
>Hi i posted my own story of using pirisudanol in this thread somewhere(if you can find it). I couldnt help notice the last bit about tardive dyskenisia which are tics (involuntary movements without purpose). My doctor who prescribed the stuff earlier this year said he himself takes pirisudanol and that it is a type of vitamin that students sometimes take to aid their studies (its sold here in spain as Mentis). Ive noticed for ages that he definately has tardive dyskenesia. Could this be related? He is a great doctor and i get along with him fantastically...
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