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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by Mishal on July 1, 2007, at 22:39:49
HiACE inhibitors which crosses blood-brain barrier have been found to have some antidepressant properties. Now, coming off prozac and being on Perindopril I find it energizing, calming and inducing an overall sense of well being. That's on a tiny dose of 4mg per day.
I will be increasing this to 8mg by next week. So far, no side effect at all but an increase in libido. This could probably be because of the sense of well being, or coming off prozac. I don't know it precisely.
Ovrall, This medication has been terrific for me.
Posted by Phillipa on July 1, 2007, at 22:45:50
In reply to Aceon (Perindopril) As an Antidepressant, posted by Mishal on July 1, 2007, at 22:39:49
May I follow your thread not familiar with this med but will google it first. Thanks Phillipa
Posted by Phillipa on July 1, 2007, at 22:50:19
In reply to Re: Aceon (Perindopril) As an Antidepressant » Mishal, posted by Phillipa on July 1, 2007, at 22:45:50
Says used for hypertension and cardiac. How did it come to be used as an antidepressant? Phillipa
Posted by steel on July 1, 2007, at 22:55:04
In reply to Re: Aceon (Perindopril) As an Antidepressant » Mishal, posted by Phillipa on July 1, 2007, at 22:45:50
> May I follow your thread not familiar with this med but will google it first. Thanks Phillipa
See phillpa,this is what people mean,no harm here to u,but ur asking to follow the thread?
As for the poster,i recomend which is what im gonna do now since u mention this,and i have access to these meds,is...
use the google MORE option.....then limit my search there to google MORE....SCHOLAR this search will only search doucments not general sites.good way to find info.Ive taken the med ace inhib before and have noticed a mind effect just never thought much of it.
Posted by steel on July 1, 2007, at 22:57:06
In reply to Aceon (Perindopril) As an Antidepressant, posted by Mishal on July 1, 2007, at 22:39:49
>
> Hi
>
> ACE inhibitors which crosses blood-brain barrier have been found to have some antidepressant properties. Now, coming off prozac and being on Perindopril I find it energizing, calming and inducing an overall sense of well being. That's on a tiny dose of 4mg per day.
>
> I will be increasing this to 8mg by next week. So far, no side effect at all but an increase in libido. This could probably be because of the sense of well being, or coming off prozac. I don't know it precisely.
>
> Ovrall, This medication has been terrific for me.Hey maybe ur one to something,seems there is a patent attempt or was on this theory,check it out,
Posted by Mishal on July 1, 2007, at 23:10:55
In reply to Re: Aceon (Perindopril) As an Antidepressant, posted by Phillipa on July 1, 2007, at 22:50:19
Hi Phillipa,
Granted, Perindopril is used to treat hypertension. But it does have some dopaminergic properties. This has been confirmed by at least one study. It should be indirectly stimulating dopamine receptors in the brain.
And we know, dopamine is the pleasure chemical. But unfortunately, trying to stimulate this chemical directly is not always successful in the cases of depression. Here is where Perindopril like drugs win, because they do the job indirectly.Right after saying good-bye to all conventional antidepressants, I am trying to fix depression by unconventional means. Perindopril plus Provigil does the trick now. Next I will be trying Ondansetron. But so far, this combination has been very effective.
Cheers
Posted by Phillipa on July 1, 2007, at 23:28:26
In reply to Re: Aceon (Perindopril) As an Antidepressant » Phillipa, posted by Mishal on July 1, 2007, at 23:10:55
Mishal thanks and why do you think you will have to find another med? And I've also heard requip for parkinsons is good for depression too. Phillipa
Posted by Mishal on July 1, 2007, at 23:37:31
In reply to Re: Aceon (Perindopril) As an Antidepressant » Mishal, posted by Phillipa on July 1, 2007, at 23:28:26
Hi Phillipa,Because, there are side effects. I am sexually dysfunctional on SSRIs. Besides there's a mental fog while I am being on these drugs.
Perindopril doesn't have these effects. Fog is now cleared. Sex is returning to normal. Don't you think these atypicals worth trying?
Posted by Phillipa on July 1, 2007, at 23:39:47
In reply to Re: Aceon (Perindopril) As an Antidepressant, posted by steel on July 1, 2007, at 22:57:06
Steel might want to add. Phillipa
Angiotensin
.
Angiotensinogen
Identifiers
Symbol AGT
Entrez 183
HUGO 333
OMIM 106150
RefSeq NM_000029
UniProt P01019
Other data
Locus Chr. 1 q41-qter
Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.Contents [hide]
1 Precursor, and types of angiotensin
1.1 Angiotensinogen
1.2 Angiotensin I
1.3 Angiotensin II
1.4 Angiotensin III
1.5 Angiotensin IV
2 Effects of angiotensin
2.1 Cardiovascular effects
2.2 Neural effects
2.3 Adrenal effects
2.4 Renal effects
3 See also
4 References
5 External links
[edit] Precursor, and types of angiotensin[edit] Angiotensinogen
Angiotensinogen is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver, although other sites are thought to be involved also. It is a member of the serpin family, although it is not known to inhibit other enzymes, unlike most serpins. Plasma angiotensinogen levels are increased by plasma corticosteroid, estrogen, thyroid hormone, and angiotensin II levels.Angiotensinogen consist of 453 amino acid residues.
[edit] Angiotensin I
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu
Renin-angiotensin-aldosterone systemAngiotensin I (CAS# 11128-99-7) is formed by the action of renin on angiotensinogen. Renin is produced in the kidneys in response to both decreased intra-renal blood pressure at the juxtaglomerular cells, or decreased delivery of Na+ and Cl- to the macula densa. If more Na+ is sensed, renin release is decreased.Renin cleaves the peptide bond between the leucine (Leu) and valine (Val) residues on angiotensinogen, creating the ten amino acid peptide (des-Asp) angiotensin I (CAS# 9041-90-1).
Angiotensin I appears to have no biological activity and exists solely as a precursor to angiotensin II.
[edit] Angiotensin II
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | His-Leu
Angiotensin I is converted to angiotensin II through removal of two terminal residues by the enzyme Angiotensin-converting enzyme (ACE, or kininase), which is found predominantly in the capillaries of the lung.[1] Angiotensin II acts as an endocrine, autocrine/ paracrine, and intracrine hormone.ACE is a target for inactivation by ACE inhibitor drugs, which decrease the rate of angiotensin II production. Other cleavage products, 7 or 9 amino acids long, are also known; they have differential affinity for angiotensin receptors, although their exact role is still unclear. The action of angiotensin II itself is targeted by angiotensin II receptor antagonists, which directly block angiotensin II AT1 receptors.
Angiotensin II is degraded to angiotensin III by angiotensinases that are located in red blood cells and the vascular beds of most tissues. It has a half-life in circulation of around 30 seconds, while in tissue, it may be as long as 15-30 minutes.
[edit] Angiotensin III
Asp | Arg-Val-Tyr-Ile-His-Pro-Phe
Angiotensin III has 40% of the pressor activity of Angiotensin II, but 100% of the aldosterone-producing activity.
[edit] Angiotensin IV
Arg | Val-Tyr-Ile-His-Pro-Phe
Angiotensin IV is a hexapeptide which, like angiotensin III, has some lesser activity.
[edit] Effects of angiotensin
See also Renin-angiotensin_system#Effects
Angiotensins II, III & IV have a number of effects throughout the body:
[edit] Cardiovascular effects
It is a potent direct vasoconstrictor, constricting arteries and veins and increasing blood pressure.Angiotensin II has prothrombotic potential through adhesion and aggregation of platelets and production of PAI-1 and PAI-2.[2][3]
It has been proposed that angiotensin II could be a cause of vascular and cardiac muscle hypertrophy (enlargement of the heart).
[edit] Neural effects
Angiotensin II increases thirst sensation (dipsogen) through the subfornical organ (SFO) of the brain, decreases the response of the baroreceptor reflex, and increases the desire for salt. It increases secretion of ADH in the posterior pituitary and secretion of ACTH in the anterior pituitary. It also potentiates the release of norepinephrine by direct action on postganglionic sympathetic fibers.
[edit] Adrenal effects
Angiotensin II acts on the adrenal cortex, causing it to release aldosterone, a hormone that causes the kidneys to retain sodium and lose potassium. Elevated plasma angiotensin II levels are responsible for the elevated aldosterone levels present during the luteal phase of the menstrual cycle.
[edit] Renal effects
Angiotensin II has a direct effect on the proximal tubules to increase Na+ resorption. Although it slightly inhibits glomerular filtration by indirectly (through sympathetic effects) and directly stimulating mesangial cell constriction, its overall effect is to increase the glomerular filtration rate by increasing the renal perfusion pressure via efferent renal arteriole constriction. Angiotensin II causes the release of prostaglandins from the kidneys.
[edit] See also
ACE inhibitor
Angiotensin receptor
Angiotensin II receptor antagonist[edit] References
Posted by Phillipa on July 1, 2007, at 23:42:00
In reply to Re: Aceon (Perindopril) As an Antidepressant » steel, posted by Phillipa on July 1, 2007, at 23:39:47
Reason I added angiotensin is it's mentioned quite frequently in the patent abstract Phillipa
Posted by Phillipa on July 1, 2007, at 23:48:38
In reply to Re: Aceon (Perindopril) As an Antidepressant » Phillipa, posted by Mishal on July 1, 2007, at 23:37:31
Well I know the second med you mention is zofran used for the nausea of chemotheraphy. Could it be that coming off the prozac is the cause of the sexual function returning and not the med? All have a high sides effect profile of dizziness and cardiac symtoms. So I don't know. Where did you hear of these meds and decide to try them? Just curious. Love Phillipa
Posted by Mishal on July 2, 2007, at 0:22:23
In reply to Re: Aceon (Perindopril) As an Antidepressant » Mishal, posted by Phillipa on July 1, 2007, at 23:48:38
I found it here: http://www.healthandage.com/PHome/gm=20!gid2=1090
Posted by Phillipa on July 2, 2007, at 11:27:32
In reply to Re: Aceon (Perindopril) As an Antidepressant » Phillipa, posted by Mishal on July 2, 2007, at 0:22:23
Does your doc believe in trying off label meds ie a parkinsone med for other issues the dopamine in your case? As I said this other babbler is using requip may be the same type of reaction. Give it a try if okay with doctor. and good luck. Phillipa
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