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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by med_empowered on November 13, 2006, at 17:43:49
I saw an article on wikipedia about this, and I read a poorly translated article (originally in Portugese) covering the concept. Bascially, the idea seems to be that since atypicals act more in the mesolimbic pathways, the brain compensates over time, which is why so many people a) need more and more atypical over time (in terms of dosage) and b) why some people end up worse after treatment with an atypical than they were before. Treatment involves re-starting neuroleptics, possibly an atypical with a typical, using clozapine (which apparently doesn't cause problems), or another "partial dopamine agonist" (the article didn't mention it, but I imagine this would mean Abilify and future D2 partial agonists would be OK).
So....
what do y'all think? Does anyone have more info about this? Its a really interesting concept.
Posted by ed_uk on November 15, 2006, at 14:50:51
In reply to Tardive Dysphrenia: anyone have info?, posted by med_empowered on November 13, 2006, at 17:43:49
Hi Med
Can you post the original article?
Ed
This is the end of the thread.
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