Psycho-Babble Medication Thread 698822

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substance P antagonists.....are they available????

Posted by rovers95 on October 29, 2006, at 18:33:54

Hi, just bin reading some stuff on substance p antagonists???are they available through prescription...........and more importantly, do they work???

mark

Re: substance P antagonists.....are they available

Posted by SLS on October 29, 2006, at 23:39:32

In reply to substance P antagonists.....are they available????, posted by rovers95 on October 29, 2006, at 18:33:54

> Hi, just bin reading some stuff on substance p antagonists???are they available through prescription...........

aprepitant (Emend)

http://en.wikipedia.org/wiki/Aprepitant

http://www.emend.com/aprepitant/emend/consumer/index.jsp

> and more importantly, do they work???

It's hard to know. Studies have been equivocal.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15173897&query_hl=8&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16248986&query_hl=8&itool=pubmed_docsum

- Scott

Re: substance P antagonists.....are they available

Posted by deniseuk190466 on November 2, 2006, at 16:00:47

In reply to Re: substance P antagonists.....are they available, posted by SLS on October 29, 2006, at 23:39:32

Personally, I don't think this looks very promising, especially when it came out lacking when compared to 20mg of Paroxetine.

I vaguely remember a guy on one of the message boards saying he had been on the trial for substance P antagonists (not in the placebo group) and he didn't feel any benefits from it.

I think the drug Nemifitide looks more promising but that seems to have disappeared off the radar.

Denise

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