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Dr. Bob is Robert Hsiung, MD,
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Posted by jrbecker on March 29, 2006, at 8:37:31
article excerpt...
"BETTER ANTIDEPRESSANT?
The deal with Servier gives Novartis U.S. rights to agomelatine, a Phase III investigational drug for the treatment of major depressive disorder, which may have advantages over existing treatments.
Agomelatine has been filed for approval in Europe but Novartis will need to conduct a clinical trial program in the United States, which analysts said suggested sales were still a number of years away.
Industry analysts at Kepler Equities said agomelatine appeared to have similar efficacy to other antidepressants such as Wyeth's Effexor and GlaxoSmithKline's Paxil, but may have fewer side effects.
"The antidepressant market is crowded, so ultimate sales of agomelatine for Novartis will depend on the success of its clinical trial program," Kepler said in a note." "
Posted by SLS on March 29, 2006, at 11:21:05
In reply to Novartis purchases U.S. rights to Agomelatine, posted by jrbecker on March 29, 2006, at 8:37:31
Woohoo!
The more, the merrier.
I was worried that this drugs wasn't going to make it over here. Let's hope that its use in Europe provides benefits to those taking it.
- Scott
Posted by linkadge on March 29, 2006, at 13:57:08
In reply to Re: Novartis purchases U.S. rights to Agomelatine, posted by SLS on March 29, 2006, at 11:21:05
I tried my own version of Agomelantine, cyproheptadine + melatonin. :)
Linkadge
Posted by SLS on March 29, 2006, at 14:06:16
In reply to Re: Novartis purchases U.S. rights to Agomelatine » SLS, posted by linkadge on March 29, 2006, at 13:57:08
> I tried my own version of Agomelantine, cyproheptadine + melatonin. :)
>
> Linkadge
So, what happened?I'm actually a little discouraged that the drug is such a potent agonist at M1 and M2 melatonin receptors. Melatonin really makes my depression worse. Of course, that might not mean anything, but...
It would be nice to have ritanserin to fool around with.
- Scott
Posted by linkadge on March 29, 2006, at 14:33:44
In reply to Re: Novartis purchases U.S. rights to Agomelatine » linkadge, posted by SLS on March 29, 2006, at 14:06:16
You're right, ritanserin would be nice!
Cyproheptadine + melatonin ameliorated stress induced insomnia when both agents alone failed.
I am a fan of cyproheptadine, some people find it a little depressing, but I find it profoundly calming.
Linkadge
Posted by ed_uk on March 29, 2006, at 15:41:20
In reply to Re: Novartis purchases U.S. rights to Agomelatine » SLS, posted by linkadge on March 29, 2006, at 14:33:44
I have some cyproheptadine. I bought it OTC. I think it was a bit depressing but it could be my imagination.
Ed
Posted by zeugma on March 29, 2006, at 19:23:50
In reply to Re: Novartis purchases U.S. rights to Agomelatine, posted by ed_uk on March 29, 2006, at 15:41:20
Hi Ed.
> I have some cyproheptadine. I bought it OTC. I think it was a bit depressing but it could be my imagination.>>
The part of the brain that gets depressed is presumably not far from the imagination. I wish it were available OTC here. I am positive I would react euthymically to it (or I imagine I would!).
-z
>
> Ed
Posted by Declan on March 29, 2006, at 20:38:01
In reply to Re: Novartis purchases U.S. rights to Agomelatine » SLS, posted by linkadge on March 29, 2006, at 14:33:44
Cyproheptadine and mirtazepine are great for sleep, while you're asleep. But on waking I thought I'd just as soon sleep badly as feel like that until lunch.
Declan
Posted by Phillipa on March 29, 2006, at 21:28:05
In reply to Re: Novartis purchases U.S. rights to Agomelatine, posted by Declan on March 29, 2006, at 20:38:01
Hi Declan haven't seen you here in a while. I have an E-mail to answer from someone you know. Love Phillipa
Posted by deniseuk on March 30, 2006, at 10:27:06
In reply to Novartis purchases U.S. rights to Agomelatine, posted by jrbecker on March 29, 2006, at 8:37:31
Hi,
Doesn't really sound like a promising drug to me, I don't mind side affects as long as the depression goes away, I'll take anything, increased weight, flatulance, lowered sex drive whatever.
When are they going to bring out some different acting drugs, what happened to this drug Nemifitide and why do these bloody trials take so long???
Denise
This is the end of the thread.
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