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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by tygereyes on October 7, 2005, at 17:58:10
I took 8 mg last night, and I haven't slept better since I was a child. It has a very natural "feel" to it - doesn't just knock you out cold when your head hits the pillow and doesn't require hours of tossing and turning, either. My first night on it, I had to get up early for work and could only sleep five hours - but there was no hangover effect at all! (I can remember all too clearly what Lunesta and Seroquel and tricyclics were like the first night; I slept ten to twelve hours and woke up feeling like I'd been hit by a truck.)
This is a very good med, albeit an expensive one.
Posted by Phillipa on October 7, 2005, at 18:31:38
In reply to Rozerem - works like a dream!, posted by tygereyes on October 7, 2005, at 17:58:10
What classification of med is it. And is it available in the usa? Fondly, Phillipa
Posted by tygereyes on October 7, 2005, at 18:46:09
In reply to Re: Rozerem - works like a dream! » tygereyes, posted by Phillipa on October 7, 2005, at 18:31:38
Yes, it just hit US pharmacies the other day.
It is a hypnotic. NOT a sedative-hypnotic, but a hypnotic. It has zero abuse potential and is not scheduled (unlike Ambien & Lunesta & obviously benzos). It works by regulating melatonin and sleep-wake cycles.
Posted by Tom Twilight on October 8, 2005, at 5:28:11
In reply to Re: Rozerem - works like a dream!, posted by tygereyes on October 7, 2005, at 18:46:09
Hey Tygereyes
I'm glad you had such a good experience with Rozerem
I know what hell insomnia is, since I'm currently suffering from it!
You said Rozerem worked partly on Melatonin receptors
Have you ever tried Melatonin?
If you have how did it compare to Rozerem?Secondly does anyone know when Rozerem will be released in the UK/Europe?
Posted by sm2010 on October 8, 2005, at 8:45:55
In reply to Rozerem - works like a dream!, posted by tygereyes on October 7, 2005, at 17:58:10
Thanks for the post, tygereyes. It would be nice if you could periodically update your experiences with Rozerem over time. Personally, I am interested in Rozerem because of it's alleged long-term usefullness since any other med that's workded for me does not do so for very long (I build up a quick tolerance).I imagine others are probably in the same boat.
Best of luck with it...hopefully it will continue to work well for you
Posted by tygereyes on October 8, 2005, at 9:16:33
In reply to Re: Rozerem - works like a dream! UK release Ed?, posted by Tom Twilight on October 8, 2005, at 5:28:11
Melatonin has never worked for me,which is why I was shocked that Rozerem did.
Posted by ed_uk on October 8, 2005, at 11:25:44
In reply to Re: Rozerem - works like a dream! UK release Ed?, posted by Tom Twilight on October 8, 2005, at 5:28:11
Hi Tom
>Secondly does anyone know when Rozerem will be released in the UK/Europe?
I just babblemailed jrbecker to see whether he knows. I also asked about Ambien CR.
~Ed
Posted by sm2010 on October 20, 2005, at 12:09:54
In reply to jrbecker » Tom Twilight, posted by ed_uk on October 8, 2005, at 11:25:44
OK, I tried the Rozerem but only for 5 days.The best way I can describe my experience is something like low-dose benadryl...makes me mildly drowsy, but not enough to fall asleep significantly earlier than usual (I did fall asleep maybe at 2-2:30 am as opposed to 3 or 4--not enough to really help me) and yet still left me with a significant next-day hangover.
The strange thing I noticed is that it seemed to make me VERY tired around 8-10 full hours after taking it...strange. Granted my trial was very brief, but I consistently experienced this every time.
Again, this is only my very brief experience, but I've decided it's not for me. I still think it may have potential for some though.
Also, as an aside I was scared about taking the first dose after reading reports of increased heart rate and the like because I had horrible cardiovascular effects with the stimulants. Rozerem did not cause any such problems for me though. In fact, it was really difficult to tell I'd taken it until nearly half a day later as mentioned above.
Oh yeah, I took the 8 mg dose... My doc said I could double up to 16 mg but I'm not going to try that.
Hope others have better luck (and insurance!)
Posted by fires on October 26, 2005, at 17:29:57
In reply to Re: Rozerem - works like a dream! UK release Ed?, posted by tygereyes on October 8, 2005, at 9:16:33
> Melatonin has never worked for me,which is why I was shocked that Rozerem did.
Melatonin is very different. Very "broad spectrum" compared to Rozerem. Melatonin:
"we don't recommend melatonin." "Nobody knows what dosages to take. Products are not standardized. Thus, you really don't know what you're swallowing."
http://www.berkeleywellness.com/html/ds/dsMelatonin.php
Posted by ironandwine on October 28, 2005, at 21:50:34
In reply to Re: jrbecker, posted by sm2010 on October 20, 2005, at 12:09:54
I am a pharm rep for Rozerem and I was doing research to see what users experiences with it have been. After reading this post, I must clarify some things that seem very misleading by this trial user.
Rozerem is a non controlled substance
it is non-scheduled. Yes, I said non scheduled. There is not a class of its own yet it is so new and innovative.
It does not cause cns depressiong
It is the first drug in 35 years created for insomnia. Yes, Ambien and Lunesta and Sonata were not made for insomnia, only sleeping.
Rozerem acts on the mt1 and mt2 receptors in the brain making it completely different than its competitors which act on benzodiazapine receptors all over the brain......Now, what does this mean? First, Rozerem is diffferent than melatonin because it has a 3-5 times great affinity for the mt1 and mt2 receptors. Once Rozerem binds to these receptors, it is 17 times more potent than indogenous melatonin. Next, because Rozerem acts on this part of the brain, which is COMPLETELY different than Ambien, Lunesta etc which are schedule 4 drugs. Rozerem is completely safe and efficacious. The longer you take Rozerem, it is more effective. Studies have proven this by 39%.
With Rozerem, there is NO dependence, NO addiction, NO hangover effect and NO rebound insomnia.
If you are a previous sedative hypnotic user, try Rozerem. It will not knock you out. That is not what it was made to do. It is indicated for the use in patients who suffer from insomnia and to reduce the time to sleep onset by 30 minutes.. Re-read that, "reduce the time to sleep onset by 30 minutes." This is why one poster on here said he fell asleep around 2am instead of 3-4am. Therefore for him, it worked better than expected, he fell asleep an hour quicker instead of just 30 minutes.
Rozerem also has a very short life and has virtually no side affects. The statement also about Rozerem increasing heart rate is very mis-calculated also. Rozerem has nothing to do with cardiovascular irregularities or increasing one's heart rate, studies have been done on this as well and in maybe less that .01 percent of patients was this shown.
>
> OK, I tried the Rozerem but only for 5 days.
>
> The best way I can describe my experience is something like low-dose benadryl...makes me mildly drowsy, but not enough to fall asleep significantly earlier than usual (I did fall asleep maybe at 2-2:30 am as opposed to 3 or 4--not enough to really help me) and yet still left me with a significant next-day hangover.
>
> The strange thing I noticed is that it seemed to make me VERY tired around 8-10 full hours after taking it...strange. Granted my trial was very brief, but I consistently experienced this every time.
>
> Again, this is only my very brief experience, but I've decided it's not for me. I still think it may have potential for some though.
>
> Also, as an aside I was scared about taking the first dose after reading reports of increased heart rate and the like because I had horrible cardiovascular effects with the stimulants. Rozerem did not cause any such problems for me though. In fact, it was really difficult to tell I'd taken it until nearly half a day later as mentioned above.
>
> Oh yeah, I took the 8 mg dose... My doc said I could double up to 16 mg but I'm not going to try that.
>
> Hope others have better luck (and insurance!)
>
>
>
>
>
Posted by Phillipa on October 28, 2005, at 22:38:46
In reply to Re: Rozerem - works like a dream! » tygereyes, posted by Phillipa on October 7, 2005, at 18:31:38
So how would this affect a person who has taken valium of over thirty years? I'm using l0mg at bedtime and another five when I wake up at night. Would this med allow me to sleep throughout the night? Fondly, Phillipa
Posted by ironandwine on October 29, 2005, at 0:58:38
In reply to Re: Rozerem - works like a dream! » Phillipa, posted by Phillipa on October 28, 2005, at 22:38:46
good question. before i answer, let me first say what i forgot to post in my previous post. Rozerem is dosed in 8mg only. Studies were done 20 times the suggested dose of 8mg and there was not any different effect on a person at 160 mg as there was in the 8mg tablet, clearly indicating Rozerem's safety and evidence of being non scheduled, non controlled, non habit forming etc.
Rozerem is not indicated to keep a patient asleep. It is only indicated to help you fall asleep. That has been a question I have seen in front of many doctors because Ambien, Lunesta etc knock you out throughout the night. But this is because they work on a different part of the brain and these drugs have a very very long half life. The longer the half lfe, the more signs of abuse and dependency as well as hangover affects next morning.
I get asked a lot, if you wake up in the middle of the night after taking Rozerem, can you take another one. The politically correct answer is no, but truthfully, I couldnt see why not. But from what I know, Rozerem is not your sedative hypnotic, it only sedates you. Rozerem however can be coadministered with everything, including valium. The only drug seen as a problem with Rozerem has been Luvox and that is because they both use the same metabolic pathway.
> So how would this affect a person who has taken valium of over thirty years? I'm using l0mg at bedtime and another five when I wake up at night. Would this med allow me to sleep throughout the night? Fondly, Phillipa
Posted by fires on October 29, 2005, at 9:24:33
In reply to Re: Rozerem - works like a dream! » Phillipa, posted by Phillipa on October 28, 2005, at 22:38:46
My experience after only 5 nights on the med.: Definitely helps me to fall asleep faster. Doesn't prevent me from waking early (as was stated).
It does seem to help me fall asleep after awakening (without taking more of it). I often awake multiple times during the early morning, but seem to fall back asleep much quicker now.
It's way too earl to be certain, but it also seems to have mood stabilizing effects for me. (Independent of sleep benefits?)
Having said that, I also have PLMS which causes sleep disturbances.
Posted by Phillipa on October 29, 2005, at 18:25:16
In reply to Re: Rozerem - works like a dream! » Phillipa, posted by fires on October 29, 2005, at 9:24:33
Well I take luvox also so I gues it's no for me. Fondly, Phillipa
This is the end of the thread.
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