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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by ed_uk on July 8, 2005, at 15:47:37
Positive data for insomnia drug
Ramelteon, a drug under investigation in the US for the treatment of insomnia, has been shown to help adults fall asleep faster and sleep for longer. The trial involved 405 adults receiving ramelteon 8mg or 16mg or placebo each night for 35 nights. Improved sleep patterns were seen after one week. The drug works by targeting two receptors in the brain, MT1 and MT2.
The data were presented at a meeting of the Associated Professional Sleep Societies last month.
Posted by rjlockhart98 on July 8, 2005, at 15:51:44
In reply to Positive data for new insomnia drug :-), posted by ed_uk on July 8, 2005, at 15:47:37
new insomnia medication!
ive got to get a ticket to this!
does it take more than a couple days to start working? do you know much on it. Affect GABA receptors?
thanks ed
matt
Posted by linkadge on July 8, 2005, at 16:54:27
In reply to Re: Positive data for new insomnia drug :-), posted by rjlockhart98 on July 8, 2005, at 15:51:44
MT1, and MT2? Haven't heard of these receptors. What are they, and do they interact with other systems?
Linkadge
Posted by ed_uk on July 8, 2005, at 17:20:15
In reply to Re: Positive data for new insomnia drug :-), posted by linkadge on July 8, 2005, at 16:54:27
>MT1, and MT2? Haven't heard of these receptors. What are they, and do they interact with other systems?
They're melatonin receptors.
~Ed
Posted by linkadge on July 8, 2005, at 18:13:28
In reply to Re: Positive data for new insomnia drug :-) » linkadge, posted by ed_uk on July 8, 2005, at 17:20:15
Why not just take melatonin.
Isn't melatonin a melatonin receptor agonist ??Linkadge
Posted by ed_uk on July 8, 2005, at 19:19:25
In reply to why not just......., posted by linkadge on July 8, 2005, at 18:13:28
LOL, that's what I thought!!! I guess you can't patent melatonin.
~ed
Posted by Declan on July 8, 2005, at 19:19:49
In reply to why not just......., posted by linkadge on July 8, 2005, at 18:13:28
I don't think melatonin works for insomnia, at least not for me. Maybe this drug will be better than melatonin.
Declan
Posted by Phillipa on July 8, 2005, at 20:41:15
In reply to Re: melatonin, posted by Declan on July 8, 2005, at 19:19:49
Believe it or not before it got all the bad press and was pulled from the US market I took it. It made me feel like I didn't want to breath. Fondly, Phillipa
Posted by Declan on July 8, 2005, at 21:00:56
In reply to Re: melatonin, posted by Phillipa on July 8, 2005, at 20:41:15
Hi Phillipa
You can't buy melatonin in health food shops (you have them?) in the US any more? I didn't know that. What was the bad PR?
Declan
Posted by linkadge on July 8, 2005, at 21:29:57
In reply to Re: melatonin, posted by Declan on July 8, 2005, at 21:00:56
I have a supply, and while it doesn't seem to help anxiety induced insomnia, it did seem to help regular tossing and turning.
Linadge
Posted by laurenjb on July 8, 2005, at 22:37:37
In reply to Re: melatonin, posted by Declan on July 8, 2005, at 21:00:56
> Hi Phillipa
> You can't buy melatonin in health food shops (you have them?) in the US any more? I didn't know that. What was the bad PR?
> DeclanHi Declan and Phillipa: Melatonin IS available in the US -- just bought some about a week ago (I live in CA) after reading an earlier thread suggesting trying it for Parnate insomnia. It seems the standard is 3mg tablets. My doctor said I could try it if I wanted but that she was wary of it since it's a hormone and largely unregulated since it's sold without a prescription. I tried 1.5mg one night and it did nothing -- might try it again if Restoril stops working completely. Hope this helps. Take care, Lauren
Posted by KaraS on July 9, 2005, at 15:54:57
In reply to Re: melatonin, posted by laurenjb on July 8, 2005, at 22:37:37
Melatonin definitely helped me get to sleep and I usually only need about 1 mg. or 1.5 mg. It didn't tend to keep me asleep through the night though. I tried a 1 mg. sustained release dosage and that did keep me asleep all night. The problem there was that i was too groggy in the morning.
There are others who have posted here who have had a lot of success with it so i definitely wouldn't rule it out without trying it.
This is the end of the thread.
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