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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by scatterbrained on April 23, 2005, at 1:28:10
The following article is a bit old but still important, especially for anybody with working memory problems.
New Haven, Conn. -- Working memory loss can be reversed using a short-term drug regimen that produces long-lasting effects, a Yale study has found.
Results from this study led by Stacy Castner at Yale School of Medicine may ultimately lead to new treatment strategies for those who have lost working or short-term memory. The team's past studies suggest that long-term treatment with antipsychotic medications for diseases such as schizophrenia, decrease the number of D1 receptors in cortical neurons. D1 receptors are one of five known dopamine receptors, which control memory function.
Published in the March 17 issue of Science, results from this new study show that long-term treatment with antipsychotic drugs produces memory impairments when the treatment lasts over several months.
"We also found that the memory deficits produced by anti-psychotic drugs can be reversed by stimulating D1 receptors with a D1 agonist-a drug that stimulates mainly D1 receptors," said Castner, associate research scientist at Yale School of Medicine.
The D1 agonist used in the study was ABT-431, an experimental and not yet available drug which effectively reversed memory loss in six primates. The improvements have been sustained for more than a year.
The return of short-term memory, which is often lost due to age and diseases such as schizophrenia and Parkinson's, is critical because short-term memory allows individuals to briefly hold information in mind while the knowledge is processed to determine an appropriate action.
It only took a relatively short treatment regimen of 25 days to get a positive effect, and it could be even shorter with the same effect, said Castner. The improvement in memory persisted for months and years after the last treatment, suggesting that the state of the circuitry involved in memory processing had been permanently or semi-permanently restored to a different level of sensitivity.
Posted by alienatari on April 23, 2005, at 5:27:08
In reply to info for anybody with working memory problems, posted by scatterbrained on April 23, 2005, at 1:28:10
Thats interesting thanks for posting the info. Gosh i wish i would have known that before I started long-term therapy with antipsychotics that have given me TD and well thats probably whats giving me my memory problems that everyone keeps complaining about :(
Dammit, why dont doctors tell us about these risks before we take these damn drugs? arghh!!!!!!
> The following article is a bit old but still important, especially for anybody with working memory problems.
>
> New Haven, Conn. -- Working memory loss can be reversed using a short-term drug regimen that produces long-lasting effects, a Yale study has found.
>
> Results from this study led by Stacy Castner at Yale School of Medicine may ultimately lead to new treatment strategies for those who have lost working or short-term memory. The team's past studies suggest that long-term treatment with antipsychotic medications for diseases such as schizophrenia, decrease the number of D1 receptors in cortical neurons. D1 receptors are one of five known dopamine receptors, which control memory function.
>
> Published in the March 17 issue of Science, results from this new study show that long-term treatment with antipsychotic drugs produces memory impairments when the treatment lasts over several months.
>
> "We also found that the memory deficits produced by anti-psychotic drugs can be reversed by stimulating D1 receptors with a D1 agonist-a drug that stimulates mainly D1 receptors," said Castner, associate research scientist at Yale School of Medicine.
>
> The D1 agonist used in the study was ABT-431, an experimental and not yet available drug which effectively reversed memory loss in six primates. The improvements have been sustained for more than a year.
>
> The return of short-term memory, which is often lost due to age and diseases such as schizophrenia and Parkinson's, is critical because short-term memory allows individuals to briefly hold information in mind while the knowledge is processed to determine an appropriate action.
>
> It only took a relatively short treatment regimen of 25 days to get a positive effect, and it could be even shorter with the same effect, said Castner. The improvement in memory persisted for months and years after the last treatment, suggesting that the state of the circuitry involved in memory processing had been permanently or semi-permanently restored to a different level of sensitivity.
>
Posted by iforgotmypassword on April 23, 2005, at 11:48:44
In reply to Re: info for anybody with working memory problems, posted by alienatari on April 23, 2005, at 5:27:08
can movement probs that may have been cause by using ssris be linked to memory and also motavation?
Posted by scatterbrained on April 23, 2005, at 14:44:00
In reply to Re: info for anybody with working memory problems, posted by alienatari on April 23, 2005, at 5:27:08
I posted this thread to show that there is a treatment being developed for short term memory impairmnent that seems very promising and unique and was wondering if anybody knows when this drug will be available. Also, from my understanding,older drugs like haldol can cause memory problems but the new atypicals are suppose to actually help with working memory. I personally haven't experienced them helping with my working memory but I guess their have been studies showing that it can.Who knows what the truth is, all I know is that there is a drug that seems to reverse impairment. This impairment is the most debilitating aspect of my illness so I would go to any length to get this drug!
Posted by iforgotmypassword on April 23, 2005, at 15:11:47
In reply to Re: info for anybody with working memory problems, posted by scatterbrained on April 23, 2005, at 14:44:00
there is a drug on that lil psychiatric drug chart as being a DA1 agonist. its called pergolide (Permax, Celance). its also a DA2 agonist though, which may be troublesome if you are prone to psychosis. if you are already taking a drug blocking those receptors (like an atypical AP?) might you already be protected. (or maybe if you increase the dose.)
http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html
Posted by Phillipa on April 23, 2005, at 18:13:26
In reply to hmm., posted by iforgotmypassword on April 23, 2005, at 15:11:47
So, for all the people that pdocs now want to tx with atypical antipshchotics for anxiety and depression, it sounds like it's not a good idea. Fondly, Phillipa
This is the end of the thread.
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