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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by Optimist on January 13, 2005, at 12:00:53
Hailing all science geeks...
I'm about to start Parnate in 5 weeks, and as I've been washing out from Prozac a few ideas popped up.
I've read that MAOi's can cause hypoglycemia. It's something I already suffer from and am a little weary about the Parnate exacerbating it. A pleasant side effect from Prozac is that I noticed it significantly abated my hypoglycemia. After further reading I noticed it had a small hyperglycemic effect. As I'm washing out of the Prozac the past few days I've noticed my hypoglycemia is getting more and more noticable.
So, I've been doing some research to figure out what I can add to Parnate to mitigate the hypoglycemic reaction. Among the drugs I've stubbled across have been Triamterene(diuretic), Lithium, Dilantin(anticonvulsant), Glucagon, and the AP's(Risperdal, Zyprexa, Abilify, etc...).
It seems that many of the drugs that increase serum glucose also decrease blood pressure which is not something that I thought would be a good idea since MAOi's already can cause hypotension.
Low dose antipsychotics seemed like a possible good way to go. The reasons for this are:
1. Can cause hyperglycemia.
2. Can have dopamine agonist effects at low dosages. Dopamine agonist drugs seem to help me the most with social anxiety/depression.
3. They have antihistamine properties which may help me out come spring/summer time with hayfever/ragweed seasonal allergies.I've read that low dose antipsychotics can have a prodopamine effect by possibly effecting the DA autoreceptors on the presynaptic area.
Any ideas or input on the validity of my thoughts regarding hypoglycemia, antihistamine response of AP's and their proposed dopamine agonist properties at low doses?
As well what possible AP's would be best suited if it is a good choice?
p.s. My diet is in very good control. I follow a Zone diet 30%/30%/40%, protein, fat, carbohydrates ratio for every meal, and have noticed this is the best for controlling my symptoms of hypoglycemia. But I find that it doesn't get rid of all the associated problems.
Thanks,
Brian
Posted by smith562 on January 13, 2005, at 19:12:16
In reply to MAOi's: hypoglycemia, AP's, DA autorec., histamine, posted by Optimist on January 13, 2005, at 12:00:53
I believe the hypoglycemia is usually seen with the hydrazine MAOIs, i.e. Nardil and Marplan. They inhibit gluconeogensis in the liver (liver releasing sugar into the blood stream in between meals and at night). I don't think parnate does this. Hope this helps.
Smith
> Hailing all science geeks...
>
> I'm about to start Parnate in 5 weeks, and as I've been washing out from Prozac a few ideas popped up.
>
> I've read that MAOi's can cause hypoglycemia. It's something I already suffer from and am a little weary about the Parnate exacerbating it. A pleasant side effect from Prozac is that I noticed it significantly abated my hypoglycemia. After further reading I noticed it had a small hyperglycemic effect. As I'm washing out of the Prozac the past few days I've noticed my hypoglycemia is getting more and more noticable.
>
> So, I've been doing some research to figure out what I can add to Parnate to mitigate the hypoglycemic reaction. Among the drugs I've stubbled across have been Triamterene(diuretic), Lithium, Dilantin(anticonvulsant), Glucagon, and the AP's(Risperdal, Zyprexa, Abilify, etc...).
>
> It seems that many of the drugs that increase serum glucose also decrease blood pressure which is not something that I thought would be a good idea since MAOi's already can cause hypotension.
>
> Low dose antipsychotics seemed like a possible good way to go. The reasons for this are:
> 1. Can cause hyperglycemia.
> 2. Can have dopamine agonist effects at low dosages. Dopamine agonist drugs seem to help me the most with social anxiety/depression.
> 3. They have antihistamine properties which may help me out come spring/summer time with hayfever/ragweed seasonal allergies.
>
> I've read that low dose antipsychotics can have a prodopamine effect by possibly effecting the DA autoreceptors on the presynaptic area.
>
> Any ideas or input on the validity of my thoughts regarding hypoglycemia, antihistamine response of AP's and their proposed dopamine agonist properties at low doses?
>
> As well what possible AP's would be best suited if it is a good choice?
>
> p.s. My diet is in very good control. I follow a Zone diet 30%/30%/40%, protein, fat, carbohydrates ratio for every meal, and have noticed this is the best for controlling my symptoms of hypoglycemia. But I find that it doesn't get rid of all the associated problems.
>
> Thanks,
>
> Brian
Posted by Optimist on January 13, 2005, at 22:31:46
In reply to Re: MAOi's: hypoglycemia, AP's, DA autorec., histamine » Optimist, posted by smith562 on January 13, 2005, at 19:12:16
Yeah that does help thanks. I may decide to take something anyways if the Parnate doesn't make it worse. I'd prefer to not have to be so diligent with my diet. I have to add more fat than I'd like to my diet in order to stabilize my blood sugar, and it still doesn't cure it totally.
This is the end of the thread.
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