![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 105 to 129 of 335. Go back in thread:
Posted by Lest on September 6, 2004, at 9:10:29
In reply to Re: Cymbalta (duloxetine) - report » 4WD, posted by theo on September 5, 2004, at 19:21:24
what side effects? or positives have you experienced, i might start it today, i have the prescription i just havent gotten it yet. i made my dr let me try cymbalta first but i had probs breathing on it, so now on to this
Posted by Lest on September 6, 2004, at 9:12:20
In reply to Re: Cymbalta (duloxetine) - report » 4WD, posted by theo on September 5, 2004, at 19:21:24
> I'm currently not on Effexor XR, haven't been in a couple of years.
>
> I'm currently only taking Lamictal and was going to add Cymbalta, but a couple of doctors have cooled my jets a little about "wanting to try something new" so I think I will wait a few months to hear more personnal experiences versus what Lilly has pumped into the media, which I hope turns out to be positive and true.
>
> I just remember being on Paxil one time feeling really good and Lexapro came out. Being the "newest and greatest" I was sucked in and switched, worst mistake I ever made.
>
> What was worse was when I went back to the Paxil, it didn't work as good and I had side effects that I didn't have before.
>
> I haven't been on any SSRI, SSNRI in a few months and have heard Prozac goes well with Lamictal. I think I'm going to try it and if it isn't doing the job in a few months and I've heard a positive response from personal friends taking Cymbalta, I might go for it.
how has lamictal helped you?
Posted by Denise1904 on September 6, 2004, at 10:00:00
In reply to Re: Cymbalta (duloxetine) - report, posted by SLS on September 6, 2004, at 8:50:42
Scott,
You're so selfless, surely, doesn't this indicate that Cymbalta is just another same as (me too) drug? I doubt that it works any more effectively really than Effexor and bringing new drugs out like this just wastes peoples time trying them.
Sorry to appear negative but it seems such a shame to get peoples hopes up yet again only to have them dashed.
Denise
Posted by rayray on September 6, 2004, at 10:03:50
In reply to Re: Cymbalta (duloxetine) - report, posted by SLS on September 6, 2004, at 8:50:42
Hi Scott,
I'm so sorry to hear that Cymbalta is not working out for you -- or at least not yet. How long a trial are you going to give it?For the last several weeks I've been scanning this board for your reports daily. You are so thoughtful and kind to do this and I (like many of your fans) appreciate it.
Hang in,
Ray
Posted by iris2 on September 6, 2004, at 10:50:58
In reply to Re: Cymbalta (duloxetine) - report » KaraS, posted by SLS on September 6, 2004, at 7:28:31
> Thanks Kara.
> I can't believe you went out of your way to do this for me. I'm not used to the kind of support that I have been receiving here over the last few weeks. I really, really, really do appreciate it.
>
> Thanks.
>
>
> - ScottScott,
I have seen the large amount of effort you put towards helping and answering people on this board. Your tone is always positive and informative. You are always kind, caring and never step on anyone’s toes or are hurtful.
You have given me personally a lot of support.
I hope it is true that what comes around goes around. You should be receiving great kindness and support. I wish all this and more for you.
Hope the Cymbalta turns around for you. Perhaps you can ride on the wave of support coming your way for the time being.
Take care for we cherish and need you,
irene
Posted by iris2 on September 6, 2004, at 12:00:36
In reply to Re: Cymbalta (duloxetine) - report » SLS, posted by iris2 on September 6, 2004, at 10:50:58
Scott,
I forgot to add. I did not know before that the "grid" of medications I copied and gave to my pdoc was all your work. I recently saw a link to your web page. Thank you for that. He was actually jealous of it and asked me where I got the information. Also you’re a good-looking guy.
Lots going for you.
You talked about several different drugs you were interested in. I cannot remember them all. I know the one I am trying Milnacipran was one among many. So you have a lot to look forward to even if the Cymbalta is not your answer.
Let me (us) know what steps you plan on taking next. I know this is premature. It is helpful to me to have your experience and knowledge.You once provided a guide for me to different supplements. I do not remember them all. I have some of them. What do you think are the most important ones to take? What tests do you think are the most important? I am going to find a doctor to test cortisal. I have a book that has other suggested tests for people taking anti depressants. I have to read it again since I do not remember them. My doctor read it and refused to do any until I provided much research to back them up. It is too much for me to concentrate and cognitively do.
Grateful for your existence,
irene
Posted by 4WD on September 6, 2004, at 12:14:43
In reply to Re: Cymbalta (duloxetine) - report » iris2, posted by iris2 on September 6, 2004, at 12:00:36
Can you please supply a link to that web page?
Marsha
Posted by iris2 on September 6, 2004, at 13:01:54
In reply to Re: Cymbalta (duloxetine) - report, posted by 4WD on September 6, 2004, at 12:14:43
> Can you please supply a link to that web page?
>
> MarshaMarsha,
Here is the link to Scotts web page. There is a link to the drug "grid" orchart there.
http://home.att.net/~sl.schofield/irene
Posted by pseudonym on September 6, 2004, at 13:20:36
In reply to Re: Cymbalta (duloxetine) - report, posted by SLS on September 6, 2004, at 8:50:42
As for your current situation, I believe Abilify + Cymbalta would not be a bad route to pursue.
It seems clear from your approach that you are targeting DA and NA neurotransmitters. Serotonergic drugs don't seem to help you much, correct? Given that you were most helped by Parnate and desipramine, it would seem likely that the selegiline patch, when released, by Watson in combination with Mylan pharmaceuticals, would be the best treatment on the surface. Why? It mediates the release of both NA and DA.
I can't determine what Lamictal and Namenda are doing for you or what lead you to take them. I recollect your explanation for Lamictal had to with "interest" and "physical energy". I would think that Abilify would be enough to do that. Your thoughts?
My two cents
Posted by theo on September 6, 2004, at 13:55:23
In reply to Re: Cymbalta (duloxetine) - report » 4WD, posted by SLS on September 5, 2004, at 20:35:57
I'm curious, my mid afternnons are my worst times also. From your past experiences, which AD's helped you better, SSRI's, Tricyclics?
Posted by theo on September 6, 2004, at 13:59:44
In reply to Re: Cymbalta (duloxetine) - report, posted by SLS on September 5, 2004, at 20:49:17
> > Scott,
> >
> > What makes you think it will not work? Did you experience any side affects? Is your mood getting depressed? How do you know it is not working?
>
> On Wednesday, I experienced a brightening of mood, an increase in interest and motivation, and an improvement in memory and concentration beyond anything I experience during the normal course of my illness. By Saturday this had pretty much disappeared, and by this afternoon, my condition deteriorated substantially. My experiences in the past with this pattern of events is that no further antidepressant response will occur, regardless of how high the dosage goes or how long I stick with it. This phenomenon is idiosyncratic to me, and not to be generalized to the population in general.
>
> I am still trying to be positive, but there is no longer optimism. This has happened too many times already.
>
>
> - ScottThat same thing happened to me with Effexor XR, that feel good teaser that unfortunately didn't continue.
Posted by mattw84 on September 6, 2004, at 14:08:56
In reply to Re: Cymbalta (duloxetine) - report for SLS JB » jrbecker, posted by mxrider on August 30, 2004, at 17:22:32
I know everyone here seems to think that wellbutrin is useless in SP.... Just thought I would share this.***********************************************************************
Bupropion-SR in treatment of social phobia.
by
Department of Psychiatry and Behavioral Sciences
Medical University of South Carolina, Charleston 29425, USA.
Emmanuel NP, Brawman-Mintzer O, Morton WA, Book SW, Johnson MR, Lorberbaum JP, Ballenger JC, Lydiard RB.
Depress Anxiety. 2000;12(2):111-3.ABSTRACT
A 12-week, open label flexible dosing study was conducted to evaluate the efficacy of bupropion-SR in the treatment of generalized social phobia. The primary outcome measures include the Clinical Global Impression of Improvement (CGI-I) and the Brief Social Phobia Rating Scale (BSPS). A total of 18 subjects were enrolled. Five of the ten subjects who completed all 12 weeks were considered as responders. Response to treatment was defined as a CGI-I score of 1 or 2, ("much improved" or "very much improved," respectively) and a > 50% decrease in BSPS score. The final doses for the completers ranged between 200 and 400 mg/day (mean 366 +/- 68 mg/day). The medication was generally well tolerated. Findings from this open-label trial suggest that bupropion-SR may be useful in treating generalized social phobia.
***********************************************************************
Posted by theo on September 6, 2004, at 14:09:05
In reply to theo, posted by Lest on September 6, 2004, at 9:12:20
It's hard to pin down the dosage, at 100mg I don't really feel much effectiveness and not many side effects. When I go above to 150mg, I feel a little more at ease in group settings but also am not sharp and on my feet like normal which means I'm experiencing side effects such as word retrieval and short term memory. Not horrible but just enough to bother me.
I recently went back down to 100mg Lamictal and am going to add 10mg of Prozac and see what happens.
Posted by theo on September 6, 2004, at 14:11:30
In reply to Re: Cymbalta (duloxetine) - report » iris2, posted by iris2 on September 6, 2004, at 12:00:36
What grid, what link?
Posted by iris2 on September 6, 2004, at 14:42:01
In reply to Re: Cymbalta (duloxetine) - report » iris2, posted by theo on September 6, 2004, at 14:11:30
> What grid, what link?
Sorry. I was speaking of Scott's home page
http://home.att.net/~sl.schofield/
with a link to a medication "grid" as I call it:
http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.htmlirene
Posted by tedar on September 6, 2004, at 15:06:25
In reply to Re: Cymbalta (duloxetine) - report, posted by theo on September 6, 2004, at 13:59:44
There just isn't any good data to suggest that Cymbalta is the answer for the upcoming years. Lilly has been trying to reinvent the next Prozac for years. We all need to keep our hopes up, but isn't this just a little cleaned up version of a tricyclic? Its discontinuation rate(do to Tolerability) in the PI was significantly higher than with the SSRIs.
Posted by mxrider on September 6, 2004, at 15:18:59
In reply to Note about wellbutrin and Soc Anx » mxrider, posted by mattw84 on September 6, 2004, at 14:08:56
>
> I know everyone here seems to think that wellbutrin is useless in SP.... Just thought I would share this.
>
> ***********************************************************************
> Bupropion-SR in treatment of social phobia.
> by
> Department of Psychiatry and Behavioral Sciences
> Medical University of South Carolina, Charleston 29425, USA.
> Emmanuel NP, Brawman-Mintzer O, Morton WA, Book SW, Johnson MR, Lorberbaum JP, Ballenger JC, Lydiard RB.
> Depress Anxiety. 2000;12(2):111-3.
>
> ABSTRACT
>
> A 12-week, open label flexible dosing study was conducted to evaluate the efficacy of bupropion-SR in the treatment of generalized social phobia. The primary outcome measures include the Clinical Global Impression of Improvement (CGI-I) and the Brief Social Phobia Rating Scale (BSPS). A total of 18 subjects were enrolled. Five of the ten subjects who completed all 12 weeks were considered as responders. Response to treatment was defined as a CGI-I score of 1 or 2, ("much improved" or "very much improved," respectively) and a > 50% decrease in BSPS score. The final doses for the completers ranged between 200 and 400 mg/day (mean 366 +/- 68 mg/day). The medication was generally well tolerated. Findings from this open-label trial suggest that bupropion-SR may be useful in treating generalized social phobia.
>
>
> ***********************************************************************Thanks for that post. That is interesting for sure...I wouldn't have thought that was the case.
I personally have postponed my Wellbutrin trial as I am having a brain scan/consultation done at the Amen clinic next week. I know this is a controversial procedure, however, after 20+ years of on and off misery, I've decided to do whatever it takes to get myself "better". I had a head injury as a young teen that occurred around the time every thing went to hell. It could be coincidental, who knows? But, I would sure like to know.Thanks,
Chris
Posted by jessie77 on September 6, 2004, at 15:59:55
In reply to Re: Note about wellbutrin and Soc Anx, posted by mxrider on September 6, 2004, at 15:18:59
ive been on cymbalta a little over a week. not to be gross, but I am seriously constipated. has this happened to anyone else?
Posted by mattw84 on September 6, 2004, at 16:01:35
In reply to Re: Note about wellbutrin and Soc Anx, posted by mxrider on September 6, 2004, at 15:18:59
I wish you the best! I have debated getting a SPECT scan done, as most of Doc Amen's patients seem to have a great outcome. I live only like 30 minutes from the clinic, only hold up is the $4000 price tag! If you end up getting the scan done be sure and keep us all posted! Good Luck!
Matt
Posted by 4WD on September 6, 2004, at 17:06:55
In reply to cymbalta side effects, posted by jessie77 on September 6, 2004, at 15:59:55
> ive been on cymbalta a little over a week. not to be gross, but I am seriously constipated. has this happened to anyone else?
I've been on it for 4 days now. No problems. It was a slight problem in the first couple of weeks on Effexor, though.
Marsha
Posted by KaraS on September 6, 2004, at 18:01:42
In reply to Re: Cymbalta (duloxetine) - report » KaraS, posted by SLS on September 6, 2004, at 7:28:31
> Thanks Kara.
>
> > Maybe you've already had the kind of testing done that he refers to in his post, but if not, it might be something to add to your toolbox.
>
> I can't believe you went out of your way to do this for me. I'm not used to the kind of support that I have been receiving here over the last few weeks. I really, really, really do appreciate it.
>
> Thanks.
>
>
> - Scott
You're welcome.BTW, I just checked out your web site and I'm still recovering from the shock. You're the last person in the world I would have thought would be into body building. First off, because you seem so cerebral but mostly because you've commented more than once on how much you hate exercise.
I couldn't help but wonder if you were depressed when you created the site. You certainly couldn't tell if you were. And, if you were, I can only imagine what you'd be capable of if you weren't depressed!
Kara
Posted by boomarang on September 6, 2004, at 18:04:19
In reply to Re: Note about wellbutrin and Soc Anx, posted by mxrider on September 6, 2004, at 15:18:59
i am so curious to hear how the amen clinic works out for you. try to keep us posted if possible.
Posted by mxrider on September 6, 2004, at 18:19:58
In reply to Re: Note about wellbutrin and Soc Anx » mxrider, posted by boomarang on September 6, 2004, at 18:04:19
> i am so curious to hear how the amen clinic works out for you. try to keep us posted if possible.
I will certainly post my experience with the Amen clinic in a couple of weeks. Hopefully I will learn something there. I will start a new thread so as not to intrude on the Cymbalta discussion.
Posted by Iansf on September 7, 2004, at 0:43:35
In reply to Note about wellbutrin and Soc Anx » mxrider, posted by mattw84 on September 6, 2004, at 14:08:56
I've been taking Wellbutrin, 450mg/d, for a long time. I find it moderately helpful for depression but absolutely useless in regard to social phobia. I have a friend who takes it for generalized anxiety disorder, with fair success, but I've never encountered anyone with social phobia who was helped by it. My one doctor even prescribed it for me at 600mg/d - still no help for social phobia. I wish.
>
> I know everyone here seems to think that wellbutrin is useless in SP.... Just thought I would share this.
>
> ***********************************************************************
> Bupropion-SR in treatment of social phobia.
> by
> Department of Psychiatry and Behavioral Sciences
> Medical University of South Carolina, Charleston 29425, USA.
> Emmanuel NP, Brawman-Mintzer O, Morton WA, Book SW, Johnson MR, Lorberbaum JP, Ballenger JC, Lydiard RB.
> Depress Anxiety. 2000;12(2):111-3.
>
> ABSTRACT
>
> A 12-week, open label flexible dosing study was conducted to evaluate the efficacy of bupropion-SR in the treatment of generalized social phobia. The primary outcome measures include the Clinical Global Impression of Improvement (CGI-I) and the Brief Social Phobia Rating Scale (BSPS). A total of 18 subjects were enrolled. Five of the ten subjects who completed all 12 weeks were considered as responders. Response to treatment was defined as a CGI-I score of 1 or 2, ("much improved" or "very much improved," respectively) and a > 50% decrease in BSPS score. The final doses for the completers ranged between 200 and 400 mg/day (mean 366 +/- 68 mg/day). The medication was generally well tolerated. Findings from this open-label trial suggest that bupropion-SR may be useful in treating generalized social phobia.
>
>
> ***********************************************************************
Posted by SLS on September 7, 2004, at 8:10:56
In reply to Re: Cymbalta (duloxetine) - report » SLS, posted by KaraS on September 6, 2004, at 18:01:42
Hi Kara.
> BTW, I just checked out your web site and I'm still recovering from the shock. You're the last person in the world I would have thought would be into body building. First off, because you seem so cerebral but mostly because you've commented more than once on how much you hate exercise.
I don't hate exercise. I am just too depleted of energy to do it. I actually enjoyed my workouts. I keep telling myself that I would profit from getting back into the gym, but I have a tough time convincing myself to walk a block to go to the mailbox. Unlike the many accounts of the benefits of exercise on depression, I received none. Pooh.
The website I put together uses only the simplest of HTML coding. It looks more impressive than it really is. And yes, I was depressed when I did it. I was motivated for some reason. I think it was because it was novel and provided a distraction. I wish something else would capture enough of my interest to draw me through the depression to invest time in. Right now, I have no motivation at all. I guess I'm burned-out from pushing so hard just to survive over the last few years.
- Scott
Go forward in thread:
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.