![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 19 to 43 of 43. Go back in thread:
Posted by alesta on August 17, 2004, at 11:38:50
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI-Not Wellbut, posted by SLS on August 17, 2004, at 10:52:52
scott,
i can't believe you feel stupid. this is very upsetting to me (i am an empathetic person--feel others emotions *very* easily). and if there's little reward, why pursue it? you don't need to. you know plenty to help people on this board with the experiences you've already had with meds. it's your charm, your presence that people are drawn to. why not just pursue happiness instead? sorry--don't mean to tell you how to live your life--i can never stop being an amateur counselor. i think i've finally overstepped my bounds on this site....i think that rejection sensitivity is setting in right about now...be gentle, people....
amy
Posted by SLS on August 17, 2004, at 12:12:40
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI---SLS, posted by alesta on August 17, 2004, at 11:38:50
Hi Amy.
You have me smiling and enjoying the warm fuzzies that effervesce from your kind words.
Thanks.
:-)
- Scott
> scott,
>
> i can't believe you feel stupid. this is very upsetting to me (i am an empathetic person--feel others emotions *very* easily). and if there's little reward, why pursue it? you don't need to. you know plenty to help people on this board with the experiences you've already had with meds. it's your charm, your presence that people are drawn to. why not just pursue happiness instead? sorry--don't mean to tell you how to live your life--i can never stop being an amateur counselor. i think i've finally overstepped my bounds on this site....i think that rejection sensitivity is setting in right about now...be gentle, people....
>
> amy
>
>
Posted by alesta on August 17, 2004, at 12:29:26
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI---SLS » alesta, posted by SLS on August 17, 2004, at 12:12:40
your welcome, scott. same here. i loved that post!!! now *that* is interesting to read...
amy :)
> Hi Amy.
>
> You have me smiling and enjoying the warm fuzzies that effervesce from your kind words.
>
> Thanks.
>
> :-)
>
>
> - Scott
>
>
> > scott,
> >
> > i can't believe you feel stupid. this is very upsetting to me (i am an empathetic person--feel others emotions *very* easily). and if there's little reward, why pursue it? you don't need to. you know plenty to help people on this board with the experiences you've already had with meds. it's your charm, your presence that people are drawn to. why not just pursue happiness instead? sorry--don't mean to tell you how to live your life--i can never stop being an amateur counselor. i think i've finally overstepped my bounds on this site....i think that rejection sensitivity is setting in right about now...be gentle, people....
> >
> > amy
> >
> >
>
>
Posted by zeugma on August 17, 2004, at 14:15:50
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI---SLS, posted by alesta on August 17, 2004, at 12:29:26
hi all. last week, when i started Ritalin, and had combined it with about 50 mg Provigil, I had mydriasis (enlarged pupils). The last time I had this side effect was on Wellbutrin, which makes me think all three drugs are dopaminergic. LSD also had this effect, and I think it also affects dopamine function, although I am less familiar with its pharmacology (I know it also functions as a serotonin agonist).
About DA and depression, I really shouldn't say, as I know for sure that I have ADHD, and that is a dopaminergic disorder beyond doubt. Attempts to correlate noradrenergic function to ADHD via genetics have been politically driven and unsuccessful, while abnormalities in dopaminergic function have been established for some years now. But there is a link, I am convinced, between ADHD severity and depression. I used to think that the ADHD caused depression as a secondary matter, i.e. by producing multiple failures in school, socially, etc., leading finally to a reactive depression. I don't believe this any more, because I think that abnormalities of DA expression strain the balance of the other amines, and that if, e.g. the dopamine transporter is overexpressed, leading to a chronically low level of synaptic dopamine, one is going to be in a constant state of hypoarousal that the brain is going to try to compensate for somehow, and this could well lead to other amines becoming hyperfunctional to the point where they themselves break down and depression results.
I think a similar thing may happen on long-term SSRI therapy, but in reverse. The hyperfunction of the serotonin system causes the dopamine system to break down to some extent. I think that it is unfortunate that so many with comorbid ADHD are treated with SSRI's, as they appear capable of creating ADHD-like symptoms in those without the disorder.Btw, someone made a suggestion a while ago that AD poop-out was so frequent on SSRI's because of a mild serotonin syndrome induced by unnecessarily high dosages. Recovery from depression requires all aminergic systems to function properly, and doctors have become so fixated on serotonin that they have been utilizing the pharmacopeia very unwisely, in my opinion. This is especially unfortunate given that the official catecholinergic alternative since the TCA's and MAOI's have fallen from favor is Wellbutrin. In my experience and in the experience of those I know, it is an extremely unpredictable drug, has an ambiguous effect on symptoms, and appears far more prone than any other AD to induce serious allergic reactions.
Posted by jrbecker on August 17, 2004, at 21:14:26
In reply to Wellbutrin DA? and digression on ADHD, posted by zeugma on August 17, 2004, at 14:15:50
Combining a Dopamine Agonist and Selective Serotonin Reuptake Inhibitor for Treatment of Depression: A Double-Blind, Randomized Study
Posted by alesta on August 18, 2004, at 1:15:58
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI, posted by jrbecker on August 17, 2004, at 21:14:26
jrbecker, you're a lifesaver! Wow. So now we’re back to square one. They are proposing that you *can* augment with something to raise dopamine levels and that it is a good idea to augment an ssri with a dopamine antagonist! so now we’re back to my original question. larry or chemist, i know this is a long series of posts, but if you could at least read my first one i would be most grateful. i won't ask another one for a loooong time.....:)...:).....please?
Amy
Posted by alesta on August 18, 2004, at 6:05:31
In reply to Re: Dopaminergic Drug/Supp.LARRY or CHEMIST help!, posted by alesta on August 18, 2004, at 1:15:58
OOPS....i meant to say dopamine agonist, not antagonist....sorry!
Posted by chemist on August 18, 2004, at 9:40:49
In reply to Re: Dopaminergic Drug/Supp.LARRY or CHEMIST help!, posted by alesta on August 18, 2004, at 6:05:31
> OOPS....i meant to say dopamine agonist, not antagonist....sorry!
hello there, chemist here...interestingly, the subject of L-theanine has reared its head on the alternative board...i am not the right person to ask about it, as i am not familiar with the chemistry of this derivative of glutamine...i think that the responses you have received are coming from folks who know their stuff, although here i go with my thoughts, you asked for it: i tend to lean towards benzodiazepines/alprazolam for anxiety issues, and am a fan of dexedrine (and adderall) to address ADD/ADHD-like problems. my experience with antidepressants has been checkered, and i glowingly endorse parnate or, failing that, luvox (fluvoxamine). if you want dopamine - and want it fast - i suggest one of the CNS stimulants. however, perhaps you can get some closure on the L-theanine issue, and this might be worth examining......do check the post on the alternatives board, as the person taking a concentrate of L-theanine did not report favorably, but you can judge the quality of information......all the best, chemist
Posted by alesta on August 18, 2004, at 9:47:28
In reply to Re: Dopaminergic Drug/Supp.LARRY or CHEMIST help! » alesta, posted by chemist on August 18, 2004, at 9:40:49
Thank you, Chemist, and it's nice to meet you! i really appreciate it. welcome back!
(: amy :)
Posted by alesta on August 18, 2004, at 9:56:11
In reply to Re: Dopaminergic Drug/Supp.LARRY or CHEMIST help! » chemist, posted by alesta on August 18, 2004, at 9:47:28
hi, chemist,
if i could just bother you for one more quick question...do the benzos slow or reduce your cognitive processes in any way?
thanks again,
amy:)
Posted by chemist on August 18, 2004, at 10:15:33
In reply to CHEMIST--quick question, posted by alesta on August 18, 2004, at 9:56:11
> hi, chemist,
>
> if i could just bother you for one more quick question...do the benzos slow or reduce your cognitive processes in any way?
>
> thanks again,
> amy:)
hello amy, pleased to meet you....my experience with benzos and xanax has been very favorable, but do keep in mind that i am biased that way. having gotten that disclaimer off my chest, i can report that aside from short-term memory problems (some of which i attribute to the meds and some to honest-to-goodness inattention), i have not had any unpleasant experiences on the meds, cognitive or otherwise. although my self-evaluation might be more grand than that of someone who can make the assessment in a more objective light (e.g., my doctor and/or therapist), all parties involved with the current regimen of luvox, dexedrine, and xanax are apparently satisfied....having tried many benzos in addition to xanax over the years, i prefer xanax but have had success with ativan, klonopin, and valium, the latter being (for me) somewhat physically sedating. i did not find tranxene to work as well as the ones i have mentioned, and did find restoril, halcion, and dalmane all appropriate for sleep, although when it has been an issue, i prefer ambien. anyhow, i do hope i have answered your question.....all the best, chemist
Posted by alesta on August 18, 2004, at 11:33:32
In reply to Dopaminergic Drug/Supp to Aug SSRI-Not Wellbutrin, posted by alesta on August 16, 2004, at 14:38:41
you can add a modest amount of methylphenidate to an SSRI to boost dopamine function.
woo hoo!
Posted by alesta on August 18, 2004, at 12:19:03
In reply to Dopaminergic Drug/Supp to Aug SSRI-Not Wellbutrin, posted by alesta on August 16, 2004, at 14:38:41
here is a web site concerning augmentation with ritalin, etc.
http://www.mhsource.com/expert/exp1012698e.html
Posted by Dave001 on August 19, 2004, at 3:28:13
In reply to Dopaminergic Drug/Supp to Aug SSRI-Not Wellbutrin, posted by alesta on August 16, 2004, at 14:38:41
> I really need some dopamine in my system. i'm starting to feel happy with the prozac, but i know i've got to replace the depleted dopamine (due to no motivation, anhedonia, etc.). i don't want to add wellbutrin because i suffer from anxiety and don't need anything anxiogenic. i really want to try l-theanine with it (it increases dopamine *and* GABA, the effect on serotonin is debatable). i just wonder if this is safe. i don't like not knowing how they will interact, and i can't find any info on this combo. does anyone know how these might interact or have any suggestions on how i can *safely* increase my dopamine levels with prozac besides adding wellbutrin? if not, and no one responds, that's ok, then i'll at least have closure and then can move on to parnate (or nardil + provigil) with certainty.
>
> you can skip this part..just venting..(And I’m used to being on the prozac now, and like its prosocial aspects, it’s how I used to be, and don’t know what’s going to happen on the next drug, or when I go off this one. I don’t even know if I would’ve posted on this board if I hadn’t started the prozac. I don’t know...maybe I’ll be okay on the parnate...I don’t know why I’m freaking out.... I just needed to vent that. I have my rare negative moments.:))
>
> amy
>There are many. One you might want to consider is pramipexole, as it has been used successfully in a number of studies (albeit not all well controlled/designed) to elicit an antidepressant response in both uni and bipolar depression.
I'm about to give pramipexole and escitalopram a try, and I've tried *a lot* of things, including high-dose Parnate + Dexedrine + Provigil + Klonopin (and yes all at the same time). Suprisingly, I didn't have to adhere to any dietary restrictions at all. I guess I just had a high tolerance to the pressor amines. Dunno.
Good luck.
Dave
Posted by alesta on August 19, 2004, at 9:09:23
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI-Not Wellbut, posted by Dave001 on August 19, 2004, at 3:28:13
thank you, dave. mirapex, huh? i'll have to look into that.
my god, you took all that stuff at the same time, and it still didn't work? talk about drug-resistant! (FYI i'm one of those people that gets drunk off one beer <g>. that combo would probably do me in.)
Good luck to you, too! keep me posted with whatever you try. :)
take care,
amy
Posted by Dave001 on August 20, 2004, at 18:25:25
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI--DAVE, posted by alesta on August 19, 2004, at 9:09:23
> thank you, dave. mirapex, huh? i'll have to look into that.
>Keep in mind that that is only one of the many options though. Have you ever tried Amantadine? Selegeline can also be used with SSRIs if the dose isn't too high (I think <= 10 mg/day). There has been at least one study on the safety of combining selegeline with an SSRI. I do share the same basic mentality with you in that I feel that SSRI monotherapy is a prescription for failure (ugh, not to get anyone discouraged though! :-) in most cases because of the effects inherent with raising serotonin, such as reduced dopamine activity and elevations in prolactin, even if subclinical. I've also seen decreased expression of nitric oxide synthase in most of the SSRI studies, including Effexor; the one exception I've found has been citalaprom/escitalaprom (Celexa/Lexapro). Incidentally, it seems that Lexapro and Mirapex are going to be used in that clinical study posted earlier in this thread.
See the URL:
http://clinicalstudies.info.nih.gov/detail/A_2004-M-0227.htmlIf you scroll down toward the bottom of the page, you'll see both "Pramipexole" and "Escitalopran" (sic) listed as "Keywords."
> my god, you took all that stuff at the same time, and it still didn't work? talk about drug-resistant! (FYI i'm one of those people that gets drunk off one beer <g>. that combo would probably do me in.)
>Yeah, well it did have some effect; it's just that the positives didn't outweigh the negatives. I was on the Dexedrine for a long time before starting the Parnate, though, so it had already lost much of its effectiveness. I started Dexedrine when I was about 17/18 for "ADD", but I really want to stop due to concerns of neurotoxicity. The problem is finding an opportune moment where I can just say, "OK, now seems like a good time to begin months of amphetamine withdrawal."
> Good luck to you, too! keep me posted with whatever you try. :)
>
Thanks, you too!Dave
Posted by dondon on August 20, 2004, at 18:47:49
In reply to Re: Dopaminergic Drug/Supp.LARRY or CHEMIST help! » chemist, posted by alesta on August 18, 2004, at 9:47:28
Sertraline is a fairly potent dopamine reuptake inhibitor. MUch more potent than wellbutrin and nomifensine. HIgh doses of sertraline such as 300 mg has an amphetamine(psychostimulant effect)
200 mg of zoloft has only moderate affinty for dopamine reuptake. But when you push the sertraline to 300 mgs it has high affinity for dopamine reuptake(amphetamine effect) .
300 mg of sertraline is the same as 60 mg of paxil. I had to squeeze a dopaminergic effect out of sertraline because my doctors would never give me a stimulant such as dexedrine or adderal.
my 2 cents.
Posted by alesta on August 21, 2004, at 17:32:26
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI--DAVE, posted by Dave001 on August 20, 2004, at 18:25:25
Hi, dave, :)
good to hear from you! Excellent job! There is so much quality information in your post that I still need to sort through. I was looking for which medications they were using in the study, but didn’t see them; guess I didn’t look hard enough.:) I checked on mirapex and it didn’t look that great from a side-effect point-of-view (e.g. hair loss!) lexapro, I don’t know too much about. I’m definitely going to check on that.
Question: you said you wanted to quit Dexedrine due to neurotoxicity. Do you feel that all stimulants are neurotoxic? I ask because I am considering augmenting prozac with low-dose Ritalin for dopamine and to combat the ssri-related fatigue.
Thank you again for your wealth of pertinent information. You’re really helpful.:)
Take care,
Amy :)> > thank you, dave. mirapex, huh? i'll have to look into that.
> >
>
> Keep in mind that that is only one of the many options though. Have you ever tried Amantadine? Selegeline can also be used with SSRIs if the dose isn't too high (I think <= 10 mg/day). There has been at least one study on the safety of combining selegeline with an SSRI. I do share the same basic mentality with you in that I feel that SSRI monotherapy is a prescription for failure (ugh, not to get anyone discouraged though! :-) in most cases because of the effects inherent with raising serotonin, such as reduced dopamine activity and elevations in prolactin, even if subclinical. I've also seen decreased expression of nitric oxide synthase in most of the SSRI studies, including Effexor; the one exception I've found has been citalaprom/escitalaprom (Celexa/Lexapro). Incidentally, it seems that Lexapro and Mirapex are going to be used in that clinical study posted earlier in this thread.
>
> See the URL:
> http://clinicalstudies.info.nih.gov/detail/A_2004-M-0227.html
>
> If you scroll down toward the bottom of the page, you'll see both "Pramipexole" and "Escitalopran" (sic) listed as "Keywords."
> > my god, you took all that stuff at the same time, and it still didn't work? talk about drug-resistant! (FYI i'm one of those people that gets drunk off one beer <g>. that combo would probably do me in.)
> >
>
> Yeah, well it did have some effect; it's just that the positives didn't outweigh the negatives. I was on the Dexedrine for a long time before starting the Parnate, though, so it had already lost much of its effectiveness. I started Dexedrine when I was about 17/18 for "ADD", but I really want to stop due to concerns of neurotoxicity. The problem is finding an opportune moment where I can just say, "OK, now seems like a good time to begin months of amphetamine withdrawal."
>
> > Good luck to you, too! keep me posted with whatever you try. :)
> >
> Thanks, you too!
>
> Dave
>
Posted by alesta on August 21, 2004, at 23:59:59
In reply to Re: Dopaminergic Drug/Supp.LARRY or CHEMIST help!, posted by dondon on August 20, 2004, at 18:47:49
hi, don!
hmmmm, that's interesting. i didn't know that zoloft had much action on dopamine reuptake. maybe i should switch to zoloft! i'll have to look into this....
thanks!
amy
> Sertraline is a fairly potent dopamine reuptake inhibitor. MUch more potent than wellbutrin and nomifensine. HIgh doses of sertraline such as 300 mg has an amphetamine(psychostimulant effect)
> 200 mg of zoloft has only moderate affinty for dopamine reuptake. But when you push the sertraline to 300 mgs it has high affinity for dopamine reuptake(amphetamine effect) .
> 300 mg of sertraline is the same as 60 mg of paxil. I had to squeeze a dopaminergic effect out of sertraline because my doctors would never give me a stimulant such as dexedrine or adderal.
> my 2 cents.
Posted by alesta on August 22, 2004, at 0:40:04
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI--DAVE, posted by alesta on August 21, 2004, at 17:32:26
actually, the more i look into it the more i think mirapex might be a great augmentation!
Posted by Dave001 on August 22, 2004, at 21:33:47
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI--DAVE, posted by alesta on August 21, 2004, at 17:32:26
>
>
> Hi, dave, :)
>
> good to hear from you! Excellent job! There is so much quality information in your post that I still need to sort through. I was looking for which medications they were using in the study, but didn’t see them; guess I didn’t look hard enough.:) I checked on mirapex and it didn’t look that great from a side-effect point-of-view (e.g. hair loss!) lexapro, I don’t know too much about. I’m definitely going to check on that.
>It certainly does seem like a lot of people have difficulty tolerating the side-effects from Mirapex. I'm even having second thoughts. I may try Amantadine or another dopaminergic before Mirapex. I sure wish amineptine were available.
> Question: you said you wanted to quit Dexedrine due to neurotoxicity. Do you feel that all stimulants are neurotoxic? I ask because I am considering augmenting prozac with low-dose Ritalin for dopamine and to combat the ssri-related fatigue.
>Unfortunately, we have no well-controlled, long-term studies evaluating the potential neurotoxicity of amphetamines or methylphenidate in humans, so it would be presumptuous of me to say that either one is toxic in humans at any specific dose range. They have been used for many years by a lot of patients, especially those with narcolepsy, and I don't believe there have been any overt manifestations of neurological damage linked to them. Whether either of them are likely to induce subtle, cognitive deficits from chronic use at doses consistent with their use in medicine is anyone's guess. The oft cited maxim, "the dose makes the poison," is no doubt applicable here. So the real question is "at which dose does *x* become toxic?" And the answer to that no doubt depends on a lot of factors and varies from person to person. From my reading of the scientific literature that we do have available on the subject (again, all based on animal studies), I'm inclined to believe that Ritalin is probably less toxic than Dexedrine at equipotent doses. However, two things to bear in mind: 1) That still doesn't mean either are toxic at typical doses used in medicine, and 2) I could be wrong.
Here is one abstract that supports this view:
---------------------------------------------
Brain Res. 1997 Aug 29;767(1):172-5.Methylphenidate and brain dopamine neurotoxicity.
Yuan J, McCann U, Ricaurte G.
Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA.
To further evaluate the dopamine (DA) neurotoxic potential of the widely prescribed psychostimulant, methylphenidate, mice were treated with various doses (range: 10-120 mg/kg) and treatment schedules of methylphenidate (every 2 h x 4 or twice daily x 4). Higher doses of methylphenidate produced intense stereotypy, as well as short- (5-day), but not long- (2-week), term depletions of striatal DA axonal markers. By contrast, amphetamine caused not only intense stereotypy, but also profound, long-lasting, dose-related DA deficits. These findings indicate that results of studies of amphetamine neurotoxicity using short (5-day) post-drug survival periods are potentially misleading. Further, the present findings confirm and extend previous results indicating that methylphenidate, unlike amphetamine, lacks DA neurotoxic potential, and strongly suggest that DA efflux, although perhaps necessary, is not sufficient for the expression of amphetamine-induced DA neurotoxicity.
PMID: 9365033
---------------------------------------------For what it's worth, I really wouldn't worry about adding Ritalin to augment your current approach. In fact, I'm going to try switching from Dexedrine to Focalin (dexmethylphenidate -- a stereoisomer of Ritalin), rather than ceasing stimulant use altogether.
> Thank you again for your wealth of pertinent information. You’re really helpful.:)
>You're more than welcome, Amy. In fact, you've helped me rethink some aspects of my own treatment (particularly WRT Mirapex, which is really a coin toss at this point), so I ought to be thanking you really.
Be sure to keep me posted on your progress, and good luck!
Dave
<snip>
Posted by alesta on August 23, 2004, at 12:44:22
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI--DAVE, posted by Dave001 on August 22, 2004, at 21:33:47
thanks for your reply, dave.:) i'm glad i could be of a little help to you, too. well, this should be my last update for a while.:) (i'm making so many pharmacological decisions lately!)
i've decided to try provigil instead of ritalin, as i think it will work better and is a little safer (from a cardio point-of-view). it is relatively expensive, and being that i have no health insurance right now i think i might wait a bit before i try it.
also, another good option might be abilify. i've read only great things about it as far as side effects and how effective it is. the only thing that concerns me (you knew this was coming:)) is this info here:
(NOTE: A joint panel of the American Diabetes Association, American Psychiatric Association, American Association of Clinical Endocrinologists, and the North American Association for the Study of Obesity has issued a consensus statement advising that patients taking atypical antipsychotics may be at increased risk for obesity, diabetes, high cholesterol, and heart disease. The panel recommends that doctors screen and monitor their patients on atypical antipsychotics for: 1) personal and family history of obesity diabetes, high cholesterol, hypertension, or cardiovascular disease; 2) weight and height; 3) waist circumference; 4) blood pressure; 5) fasting blood glucose; 6) fasting blood cholesterol.)
let me know what you think when you get a chance. how valid is the above warning?
thanks much!
amy
Posted by zuzu80 on August 23, 2004, at 17:39:00
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI--DAVE, posted by alesta on August 23, 2004, at 12:44:22
What about taking 5mg a day of Selegiline (Deprenyl,Eprenyl)?
It's a MAO-B inhibitor, ie it inhibits the activity of the enzyme that deactivates Dopamine, thus increasing dopamine concentrations.
I am thinking of taking it for Social Anxiety and Atypical depression (anhedonia,lack of energy/motivation,detachment)
Amisulpride is another option, it can increase dopaminergic transmission at low doses (25-100mg/day). It's available here in Europe but not in the USA ....
Another way of getting the Dopamine system to work optimally is, simply, to engage in regular exercise! Tommorow I will get a membership to the Training center here (just 50 meters away) and I am planing of getting at least 3days/week of one hour of aerobic exercise.
Any thoughts?
Posted by owensmar on August 23, 2004, at 20:04:07
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI-Not Wellbutrin, posted by alesta on August 17, 2004, at 7:04:08
Kara & Amy,
My personal experience with Wellbutrin was this. I had a lot of anxiety but not the ruminating kind. Just had to get up and clean the house. Was very busy feeling but took absolutely no pleasure in it. I just had to keep doing stuff even though I was hating doing it.
That would seem to indicate to me that it elevated norepinephrine levels as opposed to dopamine.
Marsha
Posted by alesta on August 24, 2004, at 11:57:35
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI, posted by zuzu80 on August 23, 2004, at 17:39:00
Hello, zuzu,:)
I had already considered selegiline (along with many other drugs), and can’t remember why, but I took it off my mental "list" of drugs to consider. So I can’t say I really know much about selegiline...um, i'm not sure a low dose of selegiline would have much effect...and you can't take high doses with an ssri. and i think it also affects serotonin(?), which i don't want with my ssri. I’m not sure about any of this, though...but I didn’t like something about it with my ssri...:) sorry i can't be more definitive, here, as i don't feel like backtracking on my research...
I don’t like the side effects of amisulpride, e.g. weight gain.About the exercise, I think it should always be tried before any drugs for psychiatric disorders. I used to feel pretty good after a workout, but I have a knee injury and can’t exercise right now. I am supposed to stay off my knee as much as possible for 1 to 2 *years* (I have chondromalacia, which is a reduction in cartilage in the knee--it takes forever to build back). I mean, I can walk normally and do everyday things just fine but anything more and I really feel it. And I’ll never heal if I don’t take it easy. At first this adjustment was so unbelievably difficult for me. But you can get used to anything, I guess..a knee replacement would be a life-saver, but I can’t afford it..the doc doesn’t know why this happened to me, and thinks it may be due to years of running track...but i digress...:)
take care,
amy
This is the end of the thread.
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