Psycho-Babble Medication Thread 371238

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Do SSRIs really raise cortisol to dangerous levels

Posted by SDA on July 27, 2004, at 13:48:16

I just read a rather disturbing article on the subject of pediatric psychiatry (http://www.antidepressantsfacts.com/tracy-cortisol-hypoglycaemia.htm). While I can see that it is clearly very biased and should be taken with a grain of salt, I am also curious about the claims it makes about cortisol. According to the article, SSRIs can double your level of cortisol with a single dose, causing brain damage. This is of particular concern to me since I was on 200mg of Zoloft from age 11 to 18.

Anyone care to comment on this?

 

Re: Do SSRIs really raise cortisol to dangerous levels

Posted by Shawn. T. on July 27, 2004, at 16:55:18

In reply to Do SSRIs really raise cortisol to dangerous levels, posted by SDA on July 27, 2004, at 13:48:16

Initially, SSRIs do increase cortisol levels in most people. However, after several days, the brain adapts to the influence of these drugs upon the HPA axis. After long-term treatment, SSRIs tend to either decrease cortisol levels or leave them unchanged. I seriously doubt that the temporary increase in cortisol induced by acute SSRI treatment would cause brain damage.

Shawn

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15127082

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15231442

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15228850

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12502009

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15240411

 

Re: Do SSRIs really raise cortisol to dangerous levels » Shawn. T.

Posted by SDA on July 28, 2004, at 15:40:15

In reply to Re: Do SSRIs really raise cortisol to dangerous levels, posted by Shawn. T. on July 27, 2004, at 16:55:18

Thanks for the links. I'll be sure to check them all out.


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