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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by SLS on July 2, 2004, at 22:32:21
A recent study reported that Seroquel (quetiapine) used as monotherapy at dosages between 300-600mg demonstrated acute antidepressant efficacy as early as the first week of treatment. I have seen someone respond this way to 700mg when added to Wellbutrin 150mg + Abilify 30mg. Until the Seroquel was added, she had not responded adequately. She has attained near total remission.
Any comments?
- Scott
Posted by linkadge on July 3, 2004, at 10:05:11
In reply to High-dose Seroquel for bipolar depression?, posted by SLS on July 2, 2004, at 22:32:21
I have read that seroquel is a 5-ht1a autoreceptor antagonist, like lithium it can boost serotonin by blocking the inhibitory autoreceptor.
Linkadge
Posted by Emme on July 3, 2004, at 11:22:53
In reply to High-dose Seroquel for bipolar depression?, posted by SLS on July 2, 2004, at 22:32:21
My pdoc has said the seroquel has mood stabilizing properties and I have a friend doing nicely on a few hundred mg of it. But I've used it for really bad anxiety and for sleep. So I thought of it as more of an anti-manic agent. For those who are depressed and not necessarily manic, how would one deal with the sedation? By balancing it out with really activating meds like your friend on Wellbutrin and abilify? I get pretty zonked by just 25 mg.
> A recent study reported that Seroquel (quetiapine) used as monotherapy at dosages between 300-600mg demonstrated acute antidepressant efficacy as early as the first week of treatment. I have seen someone respond this way to 700mg when added to Wellbutrin 150mg + Abilify 30mg. Until the Seroquel was added, she had not responded adequately. She has attained near total remission.
>
> Any comments?
>
>
> - Scott
Posted by SLS on July 4, 2004, at 8:01:43
In reply to Re: High-dose Seroquel for bipolar depression? » SLS, posted by Emme on July 3, 2004, at 11:22:53
> For those who are depressed and not necessarily manic, how would one deal with the sedation? By balancing it out with really activating meds like your friend on Wellbutrin and abilify? I get pretty zonked by just 25 mg.
It seems that Seroquel is less sedating at higher dosages - similar to Remeron.
- Scott
Posted by SLS on July 4, 2004, at 9:42:48
In reply to Re: High-dose Seroquel for bipolar depression?, posted by linkadge on July 3, 2004, at 10:05:11
> I have read that seroquel is a 5-ht1a autoreceptor antagonist, like lithium it can boost serotonin by blocking the inhibitory autoreceptor.
>
> Linkadge
Thanks.What do think of using pindolol to block 5-HT1a receptors? Do you know of anyone having success with it?
- Scott
Posted by katia on July 4, 2004, at 15:39:50
In reply to Re: High-dose Seroquel for bipolar depression?, posted by linkadge on July 3, 2004, at 10:05:11
> I have read that seroquel is a 5-ht1a autoreceptor antagonist, like lithium it can boost serotonin by blocking the inhibitory autoreceptor.
>
> LinkadgeDo you know if this happens at the lower doses, like 25mg?
Katia
Posted by linkadge on July 5, 2004, at 10:15:32
In reply to Re: High-dose Seroquel for bipolar depression? » linkadge, posted by katia on July 4, 2004, at 15:39:50
Yes it probably does have this effect at the lower doses. But it really depends on many factors to conclude if it will be noticable.
I have heard of a few people using pindolol to augment antidepressants. I have found a few reports of it making people very angry though. When I added lithium (also a 1a autoreceptor antagonist) to celexa it made me angry too.
I think there is research to suggest that excessive serotonin can cause anger, strange.A high dose SSRI + pindolol would cause a massive increase in serotonin at the synapses.
PCP is supposed to cause rages in some users by alteration of serotonin function. Check out this.
http://www.priory.com/pindolol.htm
Linkadge
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