![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by stalwart on June 24, 2004, at 3:31:39
At the anti-depressant level, are the side effects of Deprenyl more like those of Nardil or Parnate?
Personally, I was "helped" by Nardil several times over the past 20 years .However, I could only tolerate the weight gain, insomnia and afternoon sluggishness for 1 year.
Posted by Sad Panda on June 24, 2004, at 4:56:42
In reply to Deprenyl vs. Nardil and Parnate, posted by stalwart on June 24, 2004, at 3:31:39
> At the anti-depressant level, are the side effects of Deprenyl more like those of Nardil or Parnate?
>
> Personally, I was "helped" by Nardil several times over the past 20 years .However, I could only tolerate the weight gain, insomnia and afternoon sluggishness for 1 year.
>
>
>It's most like Parnate. Deprenyl & Parnate are very similar looking molecules. Deprenyl metabolises into amphetamines while Parnate metabolises into amphetamine like molecules. Nardil & Marplan are similar looking & derived from hydrazine, hence they affectionately know as rocket fuel. Marplan's effects & side effects are inbetween Nardil and Parnate so perhaps that would be one for you to try although it would probably add weight too.
Cheers,
Panda.
Posted by King Vultan on June 24, 2004, at 7:38:55
In reply to Deprenyl vs. Nardil and Parnate, posted by stalwart on June 24, 2004, at 3:31:39
> At the anti-depressant level, are the side effects of Deprenyl more like those of Nardil or Parnate?
>
> Personally, I was "helped" by Nardil several times over the past 20 years .However, I could only tolerate the weight gain, insomnia and afternoon sluggishness for 1 year.
>I think Panda's analysis is very good. As for the insomnia and afternoon sluggishness on Nardil, my conclusion is that they are related. I'm on 90 mg/day of Nardil and was so tired in the afternoon sometimes after reaching that dosage I would take a nap in my car after reaching a destination. However, as my insomnia has gone down by progressively adding various sleep aids, the problem in the afternoons has significantly declined. I have noticed some weight gain, but I seem to be effectively counteracting it, at least so far, by drastically increasing my exercise and eating more carefully.
Todd
Posted by stalwart on June 24, 2004, at 16:23:05
In reply to Re: Deprenyl vs. Nardil and Parnate » stalwart, posted by King Vultan on June 24, 2004, at 7:38:55
thanks for the info. keeping my toes crossed
Posted by stalwart on June 24, 2004, at 16:27:40
In reply to Re: Deprenyl vs. Nardil and Parnate » stalwart, posted by King Vultan on June 24, 2004, at 7:38:55
Plan is to try deprenyl and if it "fails", wash out and start Nardil. Parhaps this I will avoid eating sweets , despite the incredible cravings, and exercise.
Posted by Questionmark on June 26, 2004, at 3:04:28
In reply to Re: Deprenyl vs. Nardil and Parnate » stalwart, posted by Sad Panda on June 24, 2004, at 4:56:42
> It's most like Parnate. Deprenyl & Parnate are very similar looking molecules. Deprenyl metabolises into amphetamines while Parnate metabolises into amphetamine like molecules. Nardil & Marplan are similar looking & derived from hydrazine, hence they affectionately know as rocket fuel. Marplan's effects & side effects are inbetween Nardil and Parnate so perhaps that would be one for you to try although it would probably add weight too.
>
> Cheers,
> Panda.
(i'm just curious-- not meaning to be condescending at all, but...). How do you know that Marplan's effects & side effects are in between Nardil's and Parnate's (and not simply, for instance, very much like Nardil's but not Parnate's)? i mean i think i have heard/read people say this a few times before too, but do you have any research data or personal experience with Marplan to support this? i'm just curious because if it's true that Marplan is more or less in between Nardil and Parnate in terms of effects, i would think that it might be a really good drug for me.
Thank you.
Posted by stalwart on June 26, 2004, at 17:58:06
In reply to Re: Deprenyl vs. Nardil and Parnate » Sad Panda, posted by Questionmark on June 26, 2004, at 3:04:28
But what sort of side-efffects can one expect from Deprenyl?
Has anyone taken Deprenyl for an extended period of time?
Posted by Rick on June 26, 2004, at 19:35:20
In reply to Re: Deprenyl vs. Nardil and Parnate, posted by stalwart on June 26, 2004, at 17:58:06
> But what sort of side-efffects can one expect from Deprenyl?
>Maybe a little nervousness. (If anxiety is a major component of your depression, I'd strongly advise you to stay away from Deprenyl, aka selgiline/Eldepryl/Jumex, unless maybe you're taking a benzo at the same time.)
You probably already know this, but if you reach a dose of 15 mg or higher, Deprenyl starts becoming a non-selective MAOI like Nardil, so that all the critcal food and drug interactions must be heeded to avoid the chance of hypertensive crisis.
It may increase your libido some.
In any event, other than possible nervousness and the need to watch what you eat at higher doses, it sure won't have all the side effects that Nardil can cause! I've been there! But Nardil *has* been a godsend for many, and some people develop tolerance to most of the side effects.
Rick
Posted by Sad Panda on June 27, 2004, at 10:03:38
In reply to Re: Deprenyl vs. Nardil and Parnate » Sad Panda, posted by Questionmark on June 26, 2004, at 3:04:28
> > It's most like Parnate. Deprenyl & Parnate are very similar looking molecules. Deprenyl metabolises into amphetamines while Parnate metabolises into amphetamine like molecules. Nardil & Marplan are similar looking & derived from hydrazine, hence they affectionately know as rocket fuel. Marplan's effects & side effects are inbetween Nardil and Parnate so perhaps that would be one for you to try although it would probably add weight too.
> >
> > Cheers,
> > Panda.
>
>
> (i'm just curious-- not meaning to be condescending at all, but...). How do you know that Marplan's effects & side effects are in between Nardil's and Parnate's (and not simply, for instance, very much like Nardil's but not Parnate's)? i mean i think i have heard/read people say this a few times before too, but do you have any research data or personal experience with Marplan to support this? i'm just curious because if it's true that Marplan is more or less in between Nardil and Parnate in terms of effects, i would think that it might be a really good drug for me.
> Thank you.
>
>My opinion on Marplan is just anecdotal, I've never taken it personally & can't get it here anyhow.
Cheers,
Panda.
Posted by stalwart on June 30, 2004, at 6:22:50
In reply to Re: Deprenyl vs. Nardil and Parnate » stalwart, posted by Rick on June 26, 2004, at 19:35:20
Starting Deprenyl this Friday...5mg in AM. Also have 1mg Xanax XR and Ambien for sleep. Will keep all apprised.
Good luck to all.
Posted by Rick on June 30, 2004, at 12:37:52
In reply to Re: Deprenyl vs. Nardil and Parnate, posted by stalwart on June 30, 2004, at 6:22:50
> Starting Deprenyl this Friday...5mg in AM. Also have 1mg Xanax XR and Ambien for sleep. Will keep all apprised.
Good luck! I assume the plan is to titrate higher on the deprenyl if you're looking for antidepressant effect, though who knows, maybe 5 mg will prove enough for you ongoing.
BTW, did you find that adding Ambien was necessary for sleep even with the Xanax XR? Or were you already taking it when Xanax came into the picture? If it's the latter case, you may find that you don't really need the Ambien anymore. 1 mg Klonopin, all taken in the a.m., took care of 90% of my insomnia. As usual though, this all varies by individual and what's driving the insomnia.
Rick
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.