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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Elizabeth on October 1, 1999, at 9:42:00
I'm getting into some unknown territory here. I just took my first pill (100mg) about an hour ago. Anyone have any experience to share, or know anything about how this drug actually works? (I've heard two not-necessarily-conflicting explations.)
Posted by Brandon on October 1, 1999, at 11:47:00
In reply to modafinil [Provigil], posted by Elizabeth on October 1, 1999, at 9:42:00
> I'm getting into some unknown territory here. I just took my first pill (100mg) about an hour ago. Anyone have any experience to share, or know anything about how this drug actually works? (I've heard two not-necessarily-conflicting explations.)
Hi Elizabeth,
I dont know much about Provigil but apparently it works somewhat by stimulating Alpa1 adrenergic receptors. I know that part of the net effect is downregulation of GABA A and increased levels of L-glutamate. It's action on dopamine is very weak and dose dependant. I have been thinking of trying this new med for my ADD for awhile now. Let me know if it helps with concentration...Sorry I couldnt give you much info...you probably knew all this already.Good luck!
Brandon
Posted by Elizabeth on October 2, 1999, at 0:54:09
In reply to Re: modafinil [Provigil], posted by Brandon on October 1, 1999, at 11:47:00
I heard that either it is not noradrenergic, or it is but it is selective as to the location where it acts (which would be pretty damned cool, though I don't know how it would come about). Also heard that it may act on GABA and/or glutamate in the reticular activating system. It's not supposed to cause jitters or increased anxiety as amphetamine can. I didn't notice *any* effect, but the 100mg I took is not much at all. (I talked to my doctor on the phone and he said 200 tomorrow would be fine. My blood pressure, incidentally, was unaffected, at 108/65 (I'm taking an MAOI as well).)
Posted by avid abulia on June 19, 2003, at 15:11:46
In reply to Re: modafinil [Provigil], posted by Elizabeth on October 2, 1999, at 0:54:09
it supposedly has a very wide spectrum of action, affecting everything from gaba and noradrenaline to orexins and histamine.
i tried it a while back, it did do some good but i went off of it for some reason i can`t remember.
~AA
This is the end of the thread.
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