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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by btnd on May 30, 2003, at 14:19:38
Would taking these 2 supplements sublingually produce same effects as Picamilon? What do you think?
Posted by Larry Hoover on May 30, 2003, at 16:23:11
In reply to Sublingual GABA and nicotinamide?, posted by btnd on May 30, 2003, at 14:19:38
> Would taking these 2 supplements sublingually produce same effects as Picamilon? What do you think?
AFAIK, niacinamide and GABA are readily absorbed when used orally. I don't know that there would be any benefit from sublingual use.
Niacinamide was shown to have stronger nootropic effects than piracetam.
Biull Eksp Biol Med 1990 Oct;110(10):384-6 Related Articles, Links
[Nootropic activity of nicotinamide and its structural analogs][Article in Russian]
Akhundov RA, Zagorevskii VA, Voronina TA.
It is known that endogenic nicotinamide has a tranquilizing and stress-protective activity. The present investigations show the nootropic effect of this drug and its analogs nicomorpholine and acethylnicotinate on acute models of hypoxia and amnesia. The present results revealed that the observed nootropic activity of nicotinamide and its analogs is more expressed than this of piracetam, pyritinol and meclofenoxate. Having in mind the similarity of pharmacological effects of piracetam and nicotinamide (antihypoxic, antiamnestic and anxiolytic) we try if these drugs have electronic-structure similarities. The analysis revealed some similarity of these drugs' molecules in relation to the composition and distribution of polar centres pi- and p-electronic areas) distance between them, topography of separate molecule parts.
Posted by btnd on May 30, 2003, at 17:55:42
In reply to Re: Sublingual GABA and nicotinamide?, posted by Larry Hoover on May 30, 2003, at 16:23:11
> > Would taking these 2 supplements sublingually produce same effects as Picamilon? What do you think?
>
> AFAIK, niacinamide and GABA are readily absorbed when used orally. I don't know that there would be any benefit from sublingual use.Hmm I thought I read somewhere on the web that GABA is poorly absorbed orally and the best way to take it is sublingually. But I'm not quite sure on that.
> Niacinamide was shown to have stronger nootropic effects than piracetam.
>
> Biull Eksp Biol Med 1990 Oct;110(10):384-6 Related Articles, Links
>
>
> [Nootropic activity of nicotinamide and its structural analogs]
>
> [Article in Russian]
>
> Akhundov RA, Zagorevskii VA, Voronina TA.
>That is a great finding! I just wish they had mentioned nicotinamide doses used.
Posted by Paulie on May 30, 2003, at 18:12:22
In reply to Sublingual GABA and nicotinamide?, posted by btnd on May 30, 2003, at 14:19:38
Very good question. Unfortunately the answer is probably no. GABA does not cross the BBB(blood-brain barrier) very easily. It has low permeability with respect to BBB and only a small % actually makes it across. Taking it as a sublingual does not change that fact. Picamilon(nicotinyl-y-aminobutyric acid) on the other hand rapidly crosses the BBB. It was developed in Russia and has both tranquilizing and stimulating properties. Picamilon is actually Niacin (not nicotinamide-same as niacinamide) bonded to GABA.
How And Why Picamilon Works
by R. P. KruglikovaDrugs that normalize the gamma aminobutyric acid (GABA) system consist mainly of substances that activate GABA receptors, inhibit GABA utilization or increase the permeability of the blood-brain barrier to GABA. One-way of creating preparations of this kind is to use substances that are carriers of the GABA molecule, including vitamins or their derivatives and, in particular, nicotinic acid (niacin).
Niacin has been chosen as the carrier because of its valuable pharmacological properties, its low toxicity, and its high biological availability. It has therefore been suggested that a combination of niacin and GABA in the same molecule would increase the potency of each component.
Picamilon (nicotinyl-y-aminobutyric acid) was first synthesized at the All-Union Vitamin Research Institute in 1970. It is a white crystalline powder that is odorless, highly hygroscopic (takes up moisture readily), and readily soluble in water.In studies in animals Picamilon has been shown to have positive action on the cerebral circulation, and also exhibits the properties of a tranquilizer with a stimulating component. Unlike tranquilizer drugs, Picamilon does not induce muscle relaxation, drowsiness or lethargy.
For more info:
http://www.smart-drugs.com/picamilon-article.htm
Posted by btnd on May 30, 2003, at 20:30:54
In reply to Re: Sublingual GABA and nicotinamide?, posted by Paulie on May 30, 2003, at 18:12:22
n/m
This is the end of the thread.
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