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Dr. Bob is Robert Hsiung, MD,
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Posted by lil spunk2003 on May 13, 2003, at 0:03:56
Can someone please tell me how long Klonipin stays in your system and if you know if there is any way to get it out quicker....this is soooo important please respond
Posted by worrywort on May 13, 2003, at 12:49:44
In reply to KLonopin, posted by lil spunk2003 on May 13, 2003, at 0:03:56
Hi Spunk,
I hope this helps......
Clonazepam is rapidly and completely absorbed after oral administration. The absolute bioavailability of clonazepam is about 90%. Maximum plasma concentrations of clonazepam are reached within 1 to 4 hours after oral administration. Clonazepam is approximately 85% bound to plasma proteins. Clonazepam is highly metabolized, with less than 2% unchanged clonazepam being excreted in the urine. Biotransformation occurs mainly by reduction of the 7-nitro group to the 4-amino derivative. This derivative can be acetylated, hydroxylated, and glucuronidated. Cytochrome P-450, including CYP3A, may play an important role in clonazepam reduction and oxidation. The elimination half-life of clonazepam is typically 30 to 40 hours. Clonazepam pharmacokinetics are dose-independent throughout the dosing range.
Eric
This is the end of the thread.
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