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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Eddie Sylvano on May 2, 2003, at 16:08:29
Has anyone had any experience with this drug? It's currently used for dementia, glaucoma, pain relief, and drug addiction. I wonder if the glutamate induced damage it addresses has any hand in depressive "dementia." Overseas health sites seem to be hawking it as an anti-aging tool.
curious? http://www.memantine.com/index.htm
Posted by Ritch on May 3, 2003, at 0:30:06
In reply to Memantine (Axura), posted by Eddie Sylvano on May 2, 2003, at 16:08:29
> Has anyone had any experience with this drug? It's currently used for dementia, glaucoma, pain relief, and drug addiction. I wonder if the glutamate induced damage it addresses has any hand in depressive "dementia." Overseas health sites seem to be hawking it as an anti-aging tool.
>
> curious? http://www.memantine.com/index.htmThanks for that link! I would be greatly interested in trying Memantine with my current anticonvulsants and fish oil for bipolar depressive episodes. I liked the animation showing the calcium channel blocking action at the NMDA receptor.
Posted by SLS on May 4, 2003, at 10:18:08
In reply to Re: Memantine (Axura) » Eddie Sylvano, posted by Ritch on May 3, 2003, at 0:30:06
> > Has anyone had any experience with this drug? It's currently used for dementia, glaucoma, pain relief, and drug addiction. I wonder if the glutamate induced damage it addresses has any hand in depressive "dementia." Overseas health sites seem to be hawking it as an anti-aging tool.
> >
> > curious? http://www.memantine.com/index.htm
>
> Thanks for that link! I would be greatly interested in trying Memantine with my current anticonvulsants and fish oil for bipolar depressive episodes. I liked the animation showing the calcium channel blocking action at the NMDA receptor.
Hi.Someone who used to post on this board regularly found memantine, a NMDA receptor antagonist, to be quite effective in treating dysthymia (and possibly CFS). It seemed to help smooth out and extend the effects of the stimulants he was taking. It is touted as being able to prevent the development of tolerance to both stimulants and opioids.
A closely related drug, amantadine, also blocks NMDA receptors, and might be responsible for its ability to enhance dopaminergic neurotransmission. It is used for Parkinsons Disease and as an augmentor to antidepressants. I am planning to try amantadine soon. If it helps in any way, I will probably try to get memantine from Germany.
Memantine is in phase III trials for the indication of Alzheimer's disease. It looks like it might be approved soon.
- Scott
- Scott
Posted by jonh kimble on May 4, 2003, at 22:35:32
In reply to Re: Memantine (Axura), posted by SLS on May 4, 2003, at 10:18:08
increases dopamine transmission and antagonizes nmda? that sounds perfect! is it ever used in depression? is it fairly well known? my p docs pretty open but he really dosnt like to touch meds that have little history. thanks, and if you know, is it available in canada?
Posted by Eddie Sylvano on May 5, 2003, at 9:29:52
In reply to Re: amantadine, posted by jonh kimble on May 4, 2003, at 22:35:32
> increases dopamine transmission and antagonizes nmda? that sounds perfect! is it ever used in depression?
--------------------http://www.clinicaltrials.gov/ct/gui/show/NCT00040261?order=1
Posted by JrBecker on May 5, 2003, at 15:55:25
In reply to Re: amantadine » jonh kimble, posted by Eddie Sylvano on May 5, 2003, at 9:29:52
Don't know how effective it will be for depression, but its been getting some pretty rave reviews this week in health news circles for Alzheimer's tx...
http://www.ama-assn.org/sci-pubs/amnews/pick_03/hlsa0512.htm
http://pn.psychiatryonline.org/cgi/content/full/38/9/1-a
This is the end of the thread.
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