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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by falconman on March 17, 2003, at 22:29:07
hi,
I saw a program which touched on benzo's such as klonopin, and its relationship to dopimine reduction. I just caught the end of the show and am not sure if I grasped what was fully being said.Do benzo's effect the dopaminergic system, and if so how? I'm wondering if they could be the reason some people experince no reward value and lack of plesure whilst being on them.
I'm not sure if anyone saw it.(UK BBC11 yesterday)
Briefly the program talked about a man who was doing a bungee jump. The exhileration and extreme pleasure/high the dude experinced was attributed to the gaba system becoming less influencial in the brain. The fear and adrenalin from looking over that edge before he jumped reduced the influence of GABA, therefore when he jumped there was a huge increase in dopamine transmition as its release was less affected by the inhibitory nature of GABA.
Does this make sense to anyone else? Any thoughts surrounding this issue(or not)generally will be all good!
peace all
Falcon
Posted by Dragonslayer on March 18, 2003, at 7:54:21
In reply to benzo's reducing dopimine transmission?, posted by falconman on March 17, 2003, at 22:29:07
Posted by KrissyP on March 18, 2003, at 12:47:53
In reply to benzo's reducing dopimine transmission?, posted by falconman on March 17, 2003, at 22:29:07
Hey, I have heard this too. I do well on GABA afected meds. I take Klonopin. wish I had more to offer-Good luck:-)
Kristen
--------------------------------------------------------------------------------------------------hi,
I saw a program which touched on benzo's such as klonopin, and its relationship to dopimine reduction. I just caught the end of the show and am not sure if I grasped what was fully being said.
Do benzo's effect the dopaminergic system, and if so how? I'm wondering if they could be the reason some people experince no reward value and lack of plesure whilst being on them.
I'm not sure if anyone saw it.(UK BBC11 yesterday)
Briefly the program talked about a man who was doing a bungee jump. The exhileration and extreme pleasure/high the dude experinced was attributed to the gaba system becoming less influencial in the brain. The fear and adrenalin from looking over that edge before he jumped reduced the influence of GABA, therefore when he jumped there was a huge increase in dopamine transmition as its release was less affected by the inhibitory nature of GABA.
Does this make sense to anyone else? Any thoughts surrounding this issue(or not)generally will be all good!
peace all
Falcon
Posted by djmmm on March 18, 2003, at 15:24:20
In reply to benzo's reducing dopimine transmission?, posted by falconman on March 17, 2003, at 22:29:07
Activation of the GABA(A) system, and supression of the adenylyl cyclase cyclic AMP pathway by Klonopin causes the decrease in dopamine transmission. Most Anticonvulsants manipulate dopamine in some way (Klonopin, tegretol, zonegran, Neurontin, etc.)
Posted by falconman on March 18, 2003, at 18:41:26
In reply to Re: benzo's reducing dopimine transmission?, posted by djmmm on March 18, 2003, at 15:24:20
> Activation of the GABA(A) system, and supression of the adenylyl cyclase cyclic AMP pathway by Klonopin causes the decrease in dopamine transmission. Most Anticonvulsants manipulate dopamine in some way (Klonopin, tegretol, zonegran, Neurontin, etc.)
>
> Hi cheers for comfirming that. This could account for some of the negative effects on mood that benzo's cause.
Posted by cybercafe on March 19, 2003, at 23:57:57
In reply to Re: benzo's reducing dopimine transmission?, posted by djmmm on March 18, 2003, at 15:24:20
> Activation of the GABA(A) system, and supression of the adenylyl cyclase cyclic AMP pathway by Klonopin causes the decrease in dopamine transmission. Most Anticonvulsants manipulate dopamine in some way (Klonopin, tegretol, zonegran, Neurontin, etc.)
>
>hmmm.... can you clarify something for me? i read somewhere that D2-D4 receptors reduced adenylyl cyclase turnover ... does that mean they have an inhibitory effect?
This is the end of the thread.
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